P0A8C8 (YIDD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative membrane protein insertion efficiency factor

Gene names

Name:	yidD
Ordered Locus Names:	b4557, JW3682

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be involved in insertion of integral membrane proteins into the membrane. Ref.4
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note: Associated with the inner membrane via a putative N-terminal amphipathic helix. Ref.4
Disruption phenotype	Cells lacking this gene are viable with no apparent phenotype, but they are affected in the insertion and processing of three YidC-dependent inner membrane proteins. Ref.4
Sequence similarities	Belongs to the UPF0161 family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein insertion into membrane Inferred from mutant phenotype Ref.4. Source: EcoCyc
Cellular_component	integral to plasma membrane Inferred from direct assay Ref.4. Source: EcoCyc
Molecular_function	membrane insertase activity Inferred from mutant phenotype Ref.4. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 85	85	Putative membrane protein insertion efficiency factor HAMAP-Rule MF_00386		PRO_0000171821

Sequences

	Sequence		Length	Mass (Da)
	P0A8C8 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: DCD2A8E612D12348	FASTA	85	9,381
	10 20 30 40 50 60 MAPPLSPGSR VLIALIRVYQ RLISPLLGPH CRFTPTCSSY GIEALRRFGV IKGSWLTVKR 70 80 VLKCHPLHPG GDDPVPPGPF DTREH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Physical mapping and nucleotide sequence of the rnpA gene that encodes the protein component of ribonuclease P in Escherichia coli." Hansen F.G., Hansen E.B., Atlung T. Gene 38:85-93(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Role for Escherichia coli YidD in membrane protein insertion." Yu Z., Laven M., Klepsch M., de Gier J.W., Bitter W., van Ulsen P., Luirink J. J. Bacteriol. 193:5242-5251(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN MEMBRANE PROTEIN INSERTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11056 Genomic DNA. No translation available. U00096 Genomic DNA. Translation: ABD18707.1. AP009048 Genomic DNA. Translation: BAE77589.1.
RefSeq	YP_491730.1. NC_007779.1. YP_588472.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P0A8C8.
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b4557.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD18707; ABD18707; b4557. BAE77589; BAE77589; BAE77589.
GeneID	12933597. 1450303.
KEGG	ecj:Y75_p3468. eco:b4557.
Organism-specific databases
EchoBASE	EB1324.
EcoGene	EG11348. yidD.
Phylogenomic databases
eggNOG	COG0759.
HOGENOM	HOG000231600.
KO	K08998.
OMA	IRRFGMI.
ProtClustDB	PRK00041.
Enzyme and pathway databases
BioCyc	EcoCyc:MONOMER0-2692. ECOL316407:JW3682-MONOMER.
Gene expression databases
Genevestigator	P0A8C8.
Family and domain databases
HAMAP	MF_00386. UPF0161_YidD.
InterPro	IPR002696. Membr_insert_effic_factor. [Graphical view]
Pfam	PF01809. Haemolytic. 1 hit. [Graphical view]
ProDom	PD004225. DUF37. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00278. TIGR00278. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YIDD_ECOLI

Accession

Primary (citable) accession number: P0A8C8
Secondary accession number(s): P22847, Q2EET9, Q2M817

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program