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Protein

Putative membrane protein insertion efficiency factor

Gene

yidD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in insertion of integral membrane proteins into the membrane.UniRule annotation1 Publication

GO - Molecular functioni

  • membrane insertase activity Source: EcoCyc

GO - Biological processi

  • protein insertion into membrane Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2692.
ECOL316407:JW3682-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative membrane protein insertion efficiency factorUniRule annotation
Gene namesi
Name:yidDUniRule annotation
Ordered Locus Names:b4557, JW3682
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11348. yidD.

Subcellular locationi

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are viable with no apparent phenotype, but they are affected in the insertion and processing of three YidC-dependent inner membrane proteins.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Putative membrane protein insertion efficiency factorPRO_0000171821Add
BLAST

Proteomic databases

PaxDbiP0A8C8.

Interactioni

Protein-protein interaction databases

STRINGi511145.b4557.

Structurei

3D structure databases

ProteinModelPortaliP0A8C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0161 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VAS. Bacteria.
COG0759. LUCA.
HOGENOMiHOG000231600.
InParanoidiP0A8C8.
KOiK08998.
OMAiRCQPFHP.
OrthoDBiEOG61ZTN6.
PhylomeDBiP0A8C8.

Family and domain databases

HAMAPiMF_00386. UPF0161_YidD.
InterProiIPR002696. Membr_insert_effic_factor.
[Graphical view]
PfamiPF01809. Haemolytic. 1 hit.
[Graphical view]
ProDomiPD004225. DUF37. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01234. Haemolytic. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00278. TIGR00278. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A8C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPLSPGSR VLIALIRVYQ RLISPLLGPH CRFTPTCSSY GIEALRRFGV
60 70 80
IKGSWLTVKR VLKCHPLHPG GDDPVPPGPF DTREH
Length:85
Mass (Da):9,381
Last modified:June 7, 2005 - v1
Checksum:iDCD2A8E612D12348
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11056 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: ABD18707.1.
AP009048 Genomic DNA. Translation: BAE77589.1.
RefSeqiWP_001307474.1. NZ_LN832404.1.
YP_588472.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiABD18707; ABD18707; b4557.
BAE77589; BAE77589; BAE77589.
GeneIDi1450303.
KEGGiecj:JW3682.
eco:b4557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11056 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: ABD18707.1.
AP009048 Genomic DNA. Translation: BAE77589.1.
RefSeqiWP_001307474.1. NZ_LN832404.1.
YP_588472.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0A8C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b4557.

Proteomic databases

PaxDbiP0A8C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD18707; ABD18707; b4557.
BAE77589; BAE77589; BAE77589.
GeneIDi1450303.
KEGGiecj:JW3682.
eco:b4557.

Organism-specific databases

EchoBASEiEB1324.
EcoGeneiEG11348. yidD.

Phylogenomic databases

eggNOGiENOG4105VAS. Bacteria.
COG0759. LUCA.
HOGENOMiHOG000231600.
InParanoidiP0A8C8.
KOiK08998.
OMAiRCQPFHP.
OrthoDBiEOG61ZTN6.
PhylomeDBiP0A8C8.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2692.
ECOL316407:JW3682-MONOMER.

Miscellaneous databases

PROiP0A8C8.

Family and domain databases

HAMAPiMF_00386. UPF0161_YidD.
InterProiIPR002696. Membr_insert_effic_factor.
[Graphical view]
PfamiPF01809. Haemolytic. 1 hit.
[Graphical view]
ProDomiPD004225. DUF37. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01234. Haemolytic. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00278. TIGR00278. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Physical mapping and nucleotide sequence of the rnpA gene that encodes the protein component of ribonuclease P in Escherichia coli."
    Hansen F.G., Hansen E.B., Atlung T.
    Gene 38:85-93(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Role for Escherichia coli YidD in membrane protein insertion."
    Yu Z., Laven M., Klepsch M., de Gier J.W., Bitter W., van Ulsen P., Luirink J.
    J. Bacteriol. 193:5242-5251(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MEMBRANE PROTEIN INSERTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Entry informationi

Entry nameiYIDD_ECOLI
AccessioniPrimary (citable) accession number: P0A8C8
Secondary accession number(s): P22847, Q2EET9, Q2M817
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.