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Protein

Transaldolase A

Gene

talA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase B (talB), Transaldolase A (talA)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciEcoCyc:TRANSALDOLA-MONOMER.
ECOL316407:JW2448-MONOMER.
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase A (EC:2.2.1.2)
Gene namesi
Name:talA
Ordered Locus Names:b2464, JW2448
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11797. talA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Transaldolase APRO_0000173590Add
BLAST

Proteomic databases

EPDiP0A867.
PaxDbiP0A867.
PRIDEiP0A867.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi4260921. 6 interactions.
DIPiDIP-47872N.
IntActiP0A867. 10 interactions.
STRINGi511145.b2464.

Structurei

3D structure databases

ProteinModelPortaliP0A867.
SMRiP0A867. Positions 2-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
HOGENOMiHOG000281234.
InParanoidiP0A867.
KOiK00616.
OMAiIRLFAID.
PhylomeDBiP0A867.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELDGIKQF TTVVADSGDI ESIRHYHPQD ATTNPSLLLK AAGLSQYEHL
60 70 80 90 100
IDDAIAWGKK NGKTQEQQVV AACDKLAVNF GAEILKIVPG RVSTEVDARL
110 120 130 140 150
SFDKEKSIEK ARHLVDLYQQ QGVEKSRILI KLASTWEGIR AAEELEKEGI
160 170 180 190 200
NCNLTLLFSF AQARACAEAG VFLISPFVGR IYDWYQARKP MDPYVVEEDP
210 220 230 240 250
GVKSVRNIYD YYKQHHYETI VMGASFRRTE QILALTGCDR LTIAPNLLKE
260 270 280 290 300
LQEKVSPVVR KLIPPSQTFP RPAPMSEAEF RWEHNQDAMA VEKLSEGIRL
310
FAVDQRKLED LLAAKL
Length:316
Mass (Da):35,659
Last modified:June 7, 2005 - v1
Checksum:i990B00ED7937CF19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13159 Genomic DNA. Translation: BAA21821.1.
U00096 Genomic DNA. Translation: AAC75517.1.
AP009048 Genomic DNA. Translation: BAA16339.1.
PIRiG65021.
RefSeqiNP_416959.1. NC_000913.3.
WP_001003709.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75517; AAC75517; b2464.
BAA16339; BAA16339; BAA16339.
GeneIDi947006.
KEGGiecj:JW2448.
eco:b2464.
PATRICi32120311. VBIEscCol129921_2558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13159 Genomic DNA. Translation: BAA21821.1.
U00096 Genomic DNA. Translation: AAC75517.1.
AP009048 Genomic DNA. Translation: BAA16339.1.
PIRiG65021.
RefSeqiNP_416959.1. NC_000913.3.
WP_001003709.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A867.
SMRiP0A867. Positions 2-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260921. 6 interactions.
DIPiDIP-47872N.
IntActiP0A867. 10 interactions.
STRINGi511145.b2464.

Proteomic databases

EPDiP0A867.
PaxDbiP0A867.
PRIDEiP0A867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75517; AAC75517; b2464.
BAA16339; BAA16339; BAA16339.
GeneIDi947006.
KEGGiecj:JW2448.
eco:b2464.
PATRICi32120311. VBIEscCol129921_2558.

Organism-specific databases

EchoBASEiEB1745.
EcoGeneiEG11797. talA.

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
HOGENOMiHOG000281234.
InParanoidiP0A867.
KOiK00616.
OMAiIRLFAID.
PhylomeDBiP0A867.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
BioCyciEcoCyc:TRANSALDOLA-MONOMER.
ECOL316407:JW2448-MONOMER.

Miscellaneous databases

PROiP0A867.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTALA_ECOLI
AccessioniPrimary (citable) accession number: P0A867
Secondary accession number(s): P78258, P80218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.