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Protein

Protein TolB

Gene

tolB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Bacteriocin transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciECOL386585:GJFA-770-MONOMER.
ECOO157:TOLB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TolB
Gene namesi
Name:tolB
Ordered Locus Names:Z0908, ECs0775
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 430409Protein TolBPRO_0000034648Add
BLAST

Proteomic databases

PRIDEiP0A857.

Interactioni

Protein-protein interaction databases

IntActiP0A857. 1 interaction.
MINTiMINT-7888537.
STRINGi155864.Z0908.

Structurei

3D structure databases

ProteinModelPortaliP0A857.
SMRiP0A857. Positions 23-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TolB family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107R6Y. Bacteria.
COG0823. LUCA.
HOGENOMiHOG000004098.
KOiK03641.
OMAiVREPSWG.
OrthoDBiEOG679T7X.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.50.10070. 1 hit.
HAMAPiMF_00671. TolB.
InterProiIPR011659. PD40.
IPR014167. Tol-Pal_propeller_TolB.
IPR007195. TolB_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07676. PD40. 4 hits.
PF04052. TolB_N. 1 hit.
[Graphical view]
SUPFAMiSSF52964. SSF52964. 1 hit.
TIGRFAMsiTIGR02800. propeller_TolB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQALRVAFG FLILWASVLH AEVRIVIDSG VDSGRPIGVV PFQWAGPGAA
60 70 80 90 100
PEDIGGIVAA DLRNSGKFNP LDRARLPQQP GSAQEVQPAA WSALGIDAVV
110 120 130 140 150
VGQVTPNPDG SYNVAYQLVD TGGAPGTVLA QNSYKVNKQW LRYAGHTASD
160 170 180 190 200
EVFEKLTGIK GAFRTRIAYV VQTNGGQFPY ELRVSDYDGY NQFVVHRSPQ
210 220 230 240 250
PLMSPAWSPD GSKLAYVTFE SGRSALVIQT LANGAVRQVA SFPRHNGAPA
260 270 280 290 300
FSPDGSKLAF ALSKTGSLNL YVMDLASGQI RQVTDGRSNN TEPTWFPDSQ
310 320 330 340 350
NLAFTSDQAG RPQVYKVNIN GGAPQRITWE GSQNQDADVS SDGKFMVMVS
360 370 380 390 400
SNGGQQHIAK QDLATGGVQV LSSTFLDETP SLAPNGTMVI YSSSQGMGSV
410 420 430
LNLVSTDGRF KARLPATDGQ VKFPAWSPYL
Length:430
Mass (Da):45,956
Last modified:June 7, 2005 - v1
Checksum:i508795C6E6886B52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55076.1.
BA000007 Genomic DNA. Translation: BAB34198.1.
PIRiG90725.
H85576.
RefSeqiNP_308802.1. NC_002695.1.
WP_001295307.1. NZ_LPWC01000530.1.

Genome annotation databases

EnsemblBacteriaiAAG55076; AAG55076; Z0908.
BAB34198; BAB34198; BAB34198.
GeneIDi917506.
KEGGiece:Z0908.
ecs:ECs0775.
PATRICi18350574. VBIEscCol44059_0798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55076.1.
BA000007 Genomic DNA. Translation: BAB34198.1.
PIRiG90725.
H85576.
RefSeqiNP_308802.1. NC_002695.1.
WP_001295307.1. NZ_LPWC01000530.1.

3D structure databases

ProteinModelPortaliP0A857.
SMRiP0A857. Positions 23-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0A857. 1 interaction.
MINTiMINT-7888537.
STRINGi155864.Z0908.

Proteomic databases

PRIDEiP0A857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55076; AAG55076; Z0908.
BAB34198; BAB34198; BAB34198.
GeneIDi917506.
KEGGiece:Z0908.
ecs:ECs0775.
PATRICi18350574. VBIEscCol44059_0798.

Phylogenomic databases

eggNOGiENOG4107R6Y. Bacteria.
COG0823. LUCA.
HOGENOMiHOG000004098.
KOiK03641.
OMAiVREPSWG.
OrthoDBiEOG679T7X.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-770-MONOMER.
ECOO157:TOLB-MONOMER.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.50.10070. 1 hit.
HAMAPiMF_00671. TolB.
InterProiIPR011659. PD40.
IPR014167. Tol-Pal_propeller_TolB.
IPR007195. TolB_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07676. PD40. 4 hits.
PF04052. TolB_N. 1 hit.
[Graphical view]
SUPFAMiSSF52964. SSF52964. 1 hit.
TIGRFAMsiTIGR02800. propeller_TolB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiTOLB_ECO57
AccessioniPrimary (citable) accession number: P0A857
Secondary accession number(s): P19935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.