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Protein

Tol-Pal system protein TolB

Gene

tolB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.UniRule annotation

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Tol-Pal system protein TolBUniRule annotation
Gene namesi
Name:tolBUniRule annotation
Ordered Locus Names:Z0908, ECs0775
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Periplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_000003464822 – 430Tol-Pal system protein TolBUniRule annotationAdd BLAST409

Proteomic databases

PRIDEiP0A857

Interactioni

Subunit structurei

The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.UniRule annotation

Protein-protein interaction databases

IntActiP0A857, 1 interactor
MINTiP0A857
STRINGi155864.Z0908

Structurei

3D structure databases

ProteinModelPortaliP0A857
SMRiP0A857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TolB family.UniRule annotationCurated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107R6Y Bacteria
COG0823 LUCA
HOGENOMiHOG000004098
KOiK03641
OMAiVREPSWG

Family and domain databases

Gene3Di2.120.10.30, 1 hit
3.40.50.10070, 1 hit
HAMAPiMF_00671 TolB, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR011659 PD40
IPR014167 Tol-Pal_TolB
IPR007195 TolB_N
IPR036752 TolB_N_sf
PfamiView protein in Pfam
PF07676 PD40, 4 hits
PF04052 TolB_N, 1 hit
TIGRFAMsiTIGR02800 propeller_TolB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQALRVAFG FLILWASVLH AEVRIVIDSG VDSGRPIGVV PFQWAGPGAA
60 70 80 90 100
PEDIGGIVAA DLRNSGKFNP LDRARLPQQP GSAQEVQPAA WSALGIDAVV
110 120 130 140 150
VGQVTPNPDG SYNVAYQLVD TGGAPGTVLA QNSYKVNKQW LRYAGHTASD
160 170 180 190 200
EVFEKLTGIK GAFRTRIAYV VQTNGGQFPY ELRVSDYDGY NQFVVHRSPQ
210 220 230 240 250
PLMSPAWSPD GSKLAYVTFE SGRSALVIQT LANGAVRQVA SFPRHNGAPA
260 270 280 290 300
FSPDGSKLAF ALSKTGSLNL YVMDLASGQI RQVTDGRSNN TEPTWFPDSQ
310 320 330 340 350
NLAFTSDQAG RPQVYKVNIN GGAPQRITWE GSQNQDADVS SDGKFMVMVS
360 370 380 390 400
SNGGQQHIAK QDLATGGVQV LSSTFLDETP SLAPNGTMVI YSSSQGMGSV
410 420 430
LNLVSTDGRF KARLPATDGQ VKFPAWSPYL
Length:430
Mass (Da):45,956
Last modified:June 7, 2005 - v1
Checksum:i508795C6E6886B52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55076.1
BA000007 Genomic DNA Translation: BAB34198.1
PIRiG90725
H85576
RefSeqiNP_308802.1, NC_002695.1
WP_001295307.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55076; AAG55076; Z0908
BAB34198; BAB34198; BAB34198
GeneIDi917506
KEGGiece:Z0908
ecs:ECs0775
PATRICifig|386585.9.peg.894

Similar proteinsi

Entry informationi

Entry nameiTOLB_ECO57
AccessioniPrimary (citable) accession number: P0A857
Secondary accession number(s): P19935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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