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Protein

Sec-independent protein translocase protein TatE

Gene

tatE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA.UniRule annotation1 Publication

GO - Molecular functioni

  • protein transmembrane transporter activity Source: UniProtKB-HAMAP
  • protein transporter activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11305-MONOMER.
ECOL316407:JW0622-MONOMER.
MetaCyc:EG11305-MONOMER.

Protein family/group databases

TCDBi2.A.64.1.1. the twin arginine targeting (tat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatE
Gene namesi
Name:tatEUniRule annotation
Synonyms:ybeC
Ordered Locus Names:b0627, JW0622
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11305. tatE.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 21HelicalUniRule annotationAdd BLAST18

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
  • TAT protein transport complex Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Disruption of tatE affects the correct localization of multiple enzymes whose precursors bear twin arginine transfer peptides. Export is completely blocked when both tatA and tatE are inactivated.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000979731 – 67Sec-independent protein translocase protein TatEAdd BLAST67

Proteomic databases

PaxDbiP0A843.
PRIDEiP0A843.

Expressioni

Inductioni

Constitutively expressed.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260637. 272 interactors.
IntActiP0A843. 53 interactors.
STRINGi511145.b0627.

Structurei

3D structure databases

ProteinModelPortaliP0A843.
SMRiP0A843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatA/E family. TatE subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410607N. Bacteria.
COG1826. LUCA.
HOGENOMiHOG000245363.
InParanoidiP0A843.
KOiK03425.
OMAiDEDKPNA.

Family and domain databases

HAMAPiMF_00236. TatA_E. 1 hit.
MF_00903. TatE. 1 hit.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
IPR024905. TatE.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEISITKLL VVAALVVLLF GTKKLRTLGG DLGAAIKGFK KAMNDDDAAA
60
KKGADVDLQA EKLSHKE
Length:67
Mass (Da):7,024
Last modified:June 7, 2005 - v1
Checksum:iFA880C6DECE248A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44N → I in AAA24073 (PubMed:1577793).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82805 Genomic DNA. Translation: AAA24073.1.
U82598 Genomic DNA. Translation: AAB40827.1.
U00096 Genomic DNA. Translation: AAC73728.1.
AP009048 Genomic DNA. Translation: BAA35270.1.
PIRiJN0256.
RefSeqiNP_415160.1. NC_000913.3.
WP_000503931.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73728; AAC73728; b0627.
BAA35270; BAA35270; BAA35270.
GeneIDi945228.
KEGGiecj:JW0622.
eco:b0627.
PATRICi32116435. VBIEscCol129921_0657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82805 Genomic DNA. Translation: AAA24073.1.
U82598 Genomic DNA. Translation: AAB40827.1.
U00096 Genomic DNA. Translation: AAC73728.1.
AP009048 Genomic DNA. Translation: BAA35270.1.
PIRiJN0256.
RefSeqiNP_415160.1. NC_000913.3.
WP_000503931.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A843.
SMRiP0A843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260637. 272 interactors.
IntActiP0A843. 53 interactors.
STRINGi511145.b0627.

Protein family/group databases

TCDBi2.A.64.1.1. the twin arginine targeting (tat) family.

Proteomic databases

PaxDbiP0A843.
PRIDEiP0A843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73728; AAC73728; b0627.
BAA35270; BAA35270; BAA35270.
GeneIDi945228.
KEGGiecj:JW0622.
eco:b0627.
PATRICi32116435. VBIEscCol129921_0657.

Organism-specific databases

EchoBASEiEB1282.
EcoGeneiEG11305. tatE.

Phylogenomic databases

eggNOGiENOG410607N. Bacteria.
COG1826. LUCA.
HOGENOMiHOG000245363.
InParanoidiP0A843.
KOiK03425.
OMAiDEDKPNA.

Enzyme and pathway databases

BioCyciEcoCyc:EG11305-MONOMER.
ECOL316407:JW0622-MONOMER.
MetaCyc:EG11305-MONOMER.

Miscellaneous databases

PROiP0A843.

Family and domain databases

HAMAPiMF_00236. TatA_E. 1 hit.
MF_00903. TatE. 1 hit.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
IPR024905. TatE.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTATE_ECOLI
AccessioniPrimary (citable) accession number: P0A843
Secondary accession number(s): P25895, P77420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.