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Protein

Aerobic C4-dicarboxylate transport protein

Gene

dctA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane.1 Publication

GO - Molecular functioni

  • fumarate transmembrane transporter activity Source: EcoCyc
  • L-aspartate transmembrane transporter activity Source: EcoCyc
  • malate:proton symporter activity Source: EcoCyc
  • succinate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • fumarate transport Source: EcoliWiki
  • L-aspartate transmembrane transport Source: EcoCyc

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:DCTA-MONOMER
MetaCyc:DCTA-MONOMER

Protein family/group databases

TCDBi2.A.23.1.7 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aerobic C4-dicarboxylate transport protein
Gene namesi
Name:dctA
Ordered Locus Names:b3528, JW3496
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20044 dctA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 27HelicalSequence analysisAdd BLAST23
Transmembranei47 – 64HelicalSequence analysisAdd BLAST18
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Transmembranei141 – 163HelicalSequence analysisAdd BLAST23
Transmembranei184 – 206HelicalSequence analysisAdd BLAST23
Transmembranei219 – 241HelicalSequence analysisAdd BLAST23
Transmembranei326 – 348HelicalSequence analysisAdd BLAST23
Transmembranei352 – 374HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are only able to grow after a 2-day lag period on D-malate as sole carbon source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020941 – 428Aerobic C4-dicarboxylate transport proteinAdd BLAST428

Proteomic databases

EPDiP0A830
PaxDbiP0A830
PRIDEiP0A830

Expressioni

Inductioni

Subject to CRP-mediated catabolite repression. Repressed in the absence of oxygen, induced in the stationary phase and approximately 2-fold by citrate and C4-dicarboxylates.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262159, 13 interactors
DIPiDIP-47958N
IntActiP0A830, 1 interactor
STRINGi316407.85676516

Structurei

3D structure databases

ProteinModelPortaliP0A830
SMRiP0A830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CK2 Bacteria
COG1301 LUCA
HOGENOMiHOG000208775
InParanoidiP0A830
KOiK11103
OMAiYLYIAVI
PhylomeDBiP0A830

Family and domain databases

Gene3Di1.10.3860.10, 1 hit
HAMAPiMF_01300 C4_dicarb_transport, 1 hit
InterProiView protein in InterPro
IPR023954 C4_dicarb_transport
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSLFKSLY FQVLTAIAIG ILLGHFYPEI GEQMKPLGDG FVKLIKMIIA
60 70 80 90 100
PVIFCTVVTG IAGMESMKAV GRTGAVALLY FEIVSTIALI IGLIIVNVVQ
110 120 130 140 150
PGAGMNVDPA TLDAKAVAVY ADQAKDQGIV AFIMDVIPAS VIGAFASGNI
160 170 180 190 200
LQVLLFAVLF GFALHRLGSK GQLIFNVIES FSQVIFGIIN MIMRLAPIGA
210 220 230 240 250
FGAMAFTIGK YGVGTLVQLG QLIICFYITC ILFVVLVLGS IAKATGFSIF
260 270 280 290 300
KFIRYIREEL LIVLGTSSSE SALPRMLDKM EKLGCRKSVV GLVIPTGYSF
310 320 330 340 350
NLDGTSIYLT MAAVFIAQAT NSQMDIVHQI TLLIVLLLSS KGAAGVTGSG
360 370 380 390 400
FIVLAATLSA VGHLPVAGLA LILGIDRFMS EARALTNLVG NGVATIVVAK
410 420
WVKELDHKKL DDVLNNRAPD GKTHELSS
Length:428
Mass (Da):45,436
Last modified:June 7, 2005 - v1
Checksum:iD9B32F987B62D234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18505.1
U00096 Genomic DNA Translation: AAC76553.1
AP009048 Genomic DNA Translation: BAE77766.1
PIRiS47749
RefSeqiNP_417985.1, NC_000913.3
WP_000858214.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76553; AAC76553; b3528
BAE77766; BAE77766; BAE77766
GeneIDi948039
KEGGiecj:JW3496
eco:b3528
PATRICifig|1411691.4.peg.3189

Similar proteinsi

Entry informationi

Entry nameiDCTA_ECOLI
AccessioniPrimary (citable) accession number: P0A830
Secondary accession number(s): P37312, Q2M7J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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