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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 69ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:Z2912, ECs2570
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001655301 – 336Holliday junction ATP-dependent DNA helicase RuvBAdd BLAST336

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z2912

Structurei

3D structure databases

ProteinModelPortaliP0A813
SMRiP0A813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKJ Bacteria
COG2255 LUCA
HOGENOMiHOG000218623
KOiK03551
OMAiDEIHRMS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00016 DNA_helic_RuvB, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004605 DNA_helicase_Holl-junc_RuvB
IPR008823 DNA_helicase_Holl-junc_RuvB_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR42848 PTHR42848, 1 hit
PfamiView protein in Pfam
PF05491 RuvB_C, 1 hit
PF05496 RuvB_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005323 DNA_helicase_Holl-junc_RuvB_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00635 ruvB, 1 hit

Sequencei

Sequence statusi: Complete.

P0A813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEADRLISA GTTLPEDVAD RAIRPKLLEE YVGQPQVRSQ MEIFIKAAKL
60 70 80 90 100
RGDALDHLLI FGPPGLGKTT LANIVANEMG VNLRTTSGPV LEKAGDLAAM
110 120 130 140 150
LTNLEPHDVL FIDEIHRLSP VVEEVLYPAM EDYQLDIMIG EGPAARSIKI
160 170 180 190 200
DLPPFTLIGA TTRAGSLTSP LRDRFGIVQR LEFYQVPDLQ YIVSRSARFM
210 220 230 240 250
GLEMSDDGAL EVARRARGTP RIANRLLRRV RDFAEVKHDG TISADIAAQA
260 270 280 290 300
LDMLNVDAEG FDYMDRKLLL AVIDKFFGGP VGLDNLAAAI GEERETIEDV
310 320 330
LEPYLIQQGF LQRTPRGRMA TTRAWNHFGI TPPEMP
Length:336
Mass (Da):37,174
Last modified:August 1, 1988 - v1
Checksum:i79BAB4A9A5687F7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56850.1
BA000007 Genomic DNA Translation: BAB35993.1
PIRiB90950
F85798
RefSeqiNP_310597.1, NC_002695.1
WP_000568519.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56850; AAG56850; Z2912
BAB35993; BAB35993; BAB35993
GeneIDi913568
KEGGiece:Z2912
ecs:ECs2570
PATRICifig|386585.9.peg.2694

Similar proteinsi

Entry informationi

Entry nameiRUVB_ECO57
AccessioniPrimary (citable) accession number: P0A813
Secondary accession number(s): P08577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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