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Protein

DNA-directed RNA polymerase subunit omega

Gene

rpoZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Enzyme and pathway databases

BioCyciEcoCyc:EG10899-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit omega (EC:2.7.7.6)
Short name:
RNAP omega subunit
Alternative name(s):
RNA polymerase omega subunit
Transcriptase subunit omega
Gene namesi
Name:rpoZ
Ordered Locus Names:b3649, JW3624
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10899 rpoZ

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • RNA polymerase complex Source: EcoliWiki

Keywords - Cellular componenti

DNA-directed RNA polymerase

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001289352 – 91DNA-directed RNA polymerase subunit omegaAdd BLAST90

Proteomic databases

EPDiP0A800
PaxDbiP0A800
PRIDEiP0A800

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.1 Publication

Protein-protein interaction databases

BioGridi4259347, 290 interactors
DIPiDIP-31837N
IntActiP0A800, 27 interactors
STRINGi316385.ECDH10B_3831

Chemistry databases

BindingDBiP0A800

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 12Combined sources6
Helixi17 – 31Combined sources15
Helixi46 – 55Combined sources10
Helixi61 – 78Combined sources18
Helixi80 – 84Combined sources5
Helixi85 – 89Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IYDelectron microscopy-E2-91[»]
3LU0electron microscopy-E1-91[»]
4JK1X-ray3.90E/J1-91[»]
4JK2X-ray4.20E/J1-91[»]
4KMUX-ray3.85E/J1-91[»]
4KN4X-ray3.96E/J1-91[»]
4KN7X-ray3.69E/J1-91[»]
4MEXX-ray3.90E/K1-91[»]
4MEYX-ray3.95E/K1-91[»]
4XSXX-ray3.71E/K1-91[»]
4XSYX-ray4.01E/K1-91[»]
4XSZX-ray3.68E/K1-91[»]
4YG2X-ray3.70E/K1-91[»]
4YLNX-ray5.50E/K/Q2-91[»]
4YLOX-ray6.00E/K/Q2-91[»]
4YLPX-ray5.50E/K/Q2-91[»]
4ZH2X-ray4.20E/K1-91[»]
4ZH3X-ray4.08E/K1-91[»]
4ZH4X-ray3.99E/K1-91[»]
5BYHX-ray3.76E1-91[»]
5EZKX-ray8.50E1-91[»]
5IPLX-ray3.60E2-91[»]
5IPMX-ray4.20E2-91[»]
5IPNX-ray4.61E2-91[»]
5MS0electron microscopy9.80O1-91[»]
5MY1electron microscopy7.60Z1-91[»]
5NSRelectron microscopy3.80E1-91[»]
5NSSelectron microscopy5.80E1-91[»]
5NWTX-ray3.76E1-91[»]
5UACX-ray3.80E/K1-91[»]
5UAGX-ray3.40E/K2-91[»]
5UAHX-ray4.10E/K1-91[»]
5UAJX-ray3.92E/K1-91[»]
5UALX-ray3.89E/K1-91[»]
5UAQX-ray3.60E/K1-91[»]
5VSWX-ray4.29E/K1-91[»]
5VT0electron microscopy3.78K1-91[»]
5W1SX-ray3.81E/K1-91[»]
5W1TX-ray4.50E/K1-91[»]
6ALFelectron microscopy4.10K1-80[»]
6ALGelectron microscopy3.74K1-91[»]
6ALHelectron microscopy4.40K1-80[»]
6ASXelectron microscopy3.80K1-84[»]
6BJSelectron microscopy5.50K1-91[»]
6BYUX-ray3.60E/K1-91[»]
6C9Yelectron microscopy4.25E1-91[»]
6CA0electron microscopy5.75E1-91[»]
6FLPelectron microscopy4.10E1-91[»]
6FLQelectron microscopy4.10E1-91[»]
ProteinModelPortaliP0A800
SMRiP0A800
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A800

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105VFG Bacteria
COG1758 LUCA
HOGENOMiHOG000245721
InParanoidiP0A800
KOiK03060
OMAiLENVDNR
PhylomeDBiP0A800

Family and domain databases

Gene3Di3.90.940.10, 1 hit
HAMAPiMF_00366 RNApol_bact_RpoZ, 1 hit
InterProiView protein in InterPro
IPR003716 DNA-dir_RNA_pol_omega
IPR006110 Pol_omega/K/RPB6
IPR012293 RNAP_RPB6_omega
IPR036161 RPB6/omega_like_sf
PANTHERiPTHR34476 PTHR34476, 1 hit
PfamiView protein in Pfam
PF01192 RNA_pol_Rpb6, 1 hit
SMARTiView protein in SMART
SM01409 RNA_pol_Rpb6, 1 hit
SUPFAMiSSF63562 SSF63562, 1 hit
TIGRFAMsiTIGR00690 rpoZ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVTVQDAV EKIGNRFDLV LVAARRARQM QVGGKDPLVP EENDKTTVIA
60 70 80 90
LREIEEGLIN NQILDVRERQ EQQEQEAAEL QAVTAIAEGR R
Length:91
Mass (Da):10,237
Last modified:August 1, 1988 - v1
Checksum:i4DE7E81EF670D887
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24503 Genomic DNA Translation: AAB00159.1
M15266 Genomic DNA Translation: AAA24229.1
L10328 Genomic DNA Translation: AAA62002.1
U00096 Genomic DNA Translation: AAC76673.1
AP009048 Genomic DNA Translation: BAE77644.1
PIRiA29038 RNECO
RefSeqiNP_418106.1, NC_000913.3
WP_000135058.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76673; AAC76673; b3649
BAE77644; BAE77644; BAE77644
GeneIDi34153435
948160
KEGGiecj:JW3624
eco:b3649
PATRICifig|511145.12.peg.3769

Similar proteinsi

Entry informationi

Entry nameiRPOZ_ECOLI
AccessioniPrimary (citable) accession number: P0A800
Secondary accession number(s): P08374, Q2M7W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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