Reviewed, UniProtKB/Swiss-Prot P0A7Z2 (RPIA_ECO57)

Names and origin

Protein names

Recommended name:
    Ribose-5-phosphate isomerase A
    EC=5.3.1.6
Alternative name(s):
    Phosphoriboisomerase A
      Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	Z4252, ECs3785

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP MF_00170
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: HAMAP
Molecular function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Ribose-5-phosphate isomerase A HAMAP MF_00170		PRO_0000158413

Sequences

	Sequence		Length	Mass (Da)
	P0A7Z2-1 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: B53C49CC3DB188BC	FASTA	219	22,860
	10 20 30 40 50 60 MTQDELKKAV GWAALQYVQP GTIVGVGTGS TAAHFIDALG TMKGQIEGAV SSSDASTEKL 70 80 90 100 110 120 KSLGIHVFDL NEVDSLGIYV DGADEINGHM QMIKGGGAAL TREKIIASVA EKFICIADAS 130 140 150 160 170 180 KQVDILGKFP LPVEVIPMAR SAVARQLVKL GGRPEYRQGV VTDNGNVILD VHGMEILDPI 190 200 210 AMENAINAIP GVVTVGLFAN RGADVALIGT PDGVKTIVK

References

[1]

"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed: 11206551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.

[2]

"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005174 Genomic DNA. Translation: AAG58041.1. BA000007 Genomic DNA. Translation: BAB37208.1.
PIR	A98102. E85947.
RefSeq	NP_289482.1. NP_311812.1.
3D structure databases
SMR	P0A7Z2. Positions 2-219.
ModBase	Search...
Genome annotation databases
GeneID	916389. 958393.
GenomeReviews	Gene locus Z4252 in contig AE005174_GR. Gene locus ECs3785 in contig BA000007_GR.
KEGG	ece:Z4252. ecs:ECs3785.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0A7Z2.
OMA	P0A7Z2. ADKFICI.
Enzyme and pathway databases
BioCyc	ECOL83334:ECS3785-MON.
Family and domain databases
HAMAP	MF_00170. [Tree]
InterPro	IPR004788. RpiA. [Graphical view]
PANTHER	PTHR11934. RpiA. 1 hit.
Pfam	PF06026. Rib_5-P_isom_A. 1 hit. [Graphical view]
ProDom	PD005813. RpiA. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00021. rpiA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPIA_ECO57

Accession

Primary (citable) accession number: P0A7Z2
Secondary accession number(s): P27252

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)