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Protein

30S ribosomal protein S4

Gene

rpsD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.By similarity
With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).By similarity
Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA.By similarity
Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor, Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
Biological processTranscription, Transcription regulation, Transcription termination, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S4
Gene namesi
Name:rpsD
Synonyms:ramA
Ordered Locus Names:Z4666, ECs4161
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001323822 – 20630S ribosomal protein S4Add BLAST205

Proteomic databases

PRIDEiP0A7W0

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts protein S5. Some nascent polypeptide chains are able to cross-link to this protein in situ (By similarity).By similarity

Protein-protein interaction databases

STRINGi155864.Z4666

Structurei

3D structure databases

ProteinModelPortaliP0A7W0
SMRiP0A7W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 156S4 RNA-bindingAdd BLAST61

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105G6W Bacteria
COG0522 LUCA
HOGENOMiHOG000221003
KOiK02986
OMAiDNVVFRM

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
HAMAPiMF_01306_B Ribosomal_S4_B, 1 hit
InterProiView protein in InterPro
IPR022801 Ribosomal_S4/S9
IPR001912 Ribosomal_S4/S9_N
IPR005709 Ribosomal_S4_bac-type
IPR018079 Ribosomal_S4_CS
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR11831 PTHR11831, 1 hit
PTHR11831:SF4 PTHR11831:SF4, 1 hit
PfamiView protein in Pfam
PF00163 Ribosomal_S4, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM01390 Ribosomal_S4, 1 hit
SM00363 S4, 1 hit
TIGRFAMsiTIGR01017 rpsD_bact, 1 hit
PROSITEiView protein in PROSITE
PS00632 RIBOSOMAL_S4, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A7W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYLGPKLK LSRREGTDLF LKSGVRAIDT KCKIEQAPGQ HGARKPRLSD
60 70 80 90 100
YGVQLREKQK VRRIYGVLER QFRNYYKEAA RLKGNTGENL LALLEGRLDN
110 120 130 140 150
VVYRMGFGAT RAEARQLVSH KAIMVNGRVV NIASYQVSPN DVVSIREKAK
160 170 180 190 200
KQSRVKAALE LAEQREKPTW LEVDAGKMEG TFKRKPERSD LSADINEHLI

VELYSK
Length:206
Mass (Da):23,469
Last modified:January 23, 2007 - v2
Checksum:i4015969DF8E582BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58417.1
BA000007 Genomic DNA Translation: BAB37584.1
PIRiA91149
E85994
RefSeqiNP_312188.1, NC_002695.1
WP_000135224.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58417; AAG58417; Z4666
BAB37584; BAB37584; BAB37584
GeneIDi35807177
915983
KEGGiece:Z4666
ecs:ECs4161
PATRICifig|386585.9.peg.4344

Similar proteinsi

Entry informationi

Entry nameiRS4_ECO57
AccessioniPrimary (citable) accession number: P0A7W0
Secondary accession number(s): P02354
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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