P0A7J6 (RL10_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L10

Gene names

Name:	rplJ
Ordered Locus Names:	SF4058, S3677

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

623 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA By similarity. HAMAP MF_00362
Miscellaneous	Ribosomal protein L8 appears to be an aggregate of ribosomal proteins L7/L12 and L10 By similarity. HAMAP MF_00362
Sequence similarities	Belongs to the ribosomal protein L10P family.

Ontologies

Keywords
Biological process	Translation regulation
Ligand	RNA-binding
Molecular function	Repressor Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW ribosome biogenesis Inferred from electronic annotation. Source: InterPro translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 165	164	50S ribosomal protein L10 HAMAP MF_00362		PRO_0000154704
Amino acid modifications
	Modified residue	37	1	N6-acetyllysine By similarity
	Modified residue	105	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A7J6 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: F15822B0EDB6AC02	FASTA	165	17,712
	10 20 30 40 50 60 MALNLQDKQA IVAEVSEVAK GALSAVVADS RGVTVDKMTE LRKAGREAGV YMRVVRNTLL 70 80 90 100 110 120 RRAVEGTPFE CLKDAFVGPT LIAYSMEHPG AAARLFKEFA KANAKFEVKA AAFEGELIPA 130 140 150 160 SQIDRLATLP TYEEAIARLM ATMKEASAGK LVRTLAAVRD AKEAA

References

[1]

"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.

[2]

"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005674 Genomic DNA. Translation: AAN45487.1. AE014073 Genomic DNA. Translation: AAP18714.1.
RefSeq	NP_709780.1. NC_004337.2. NP_838903.1. NC_004741.1.
3D structure databases
ProteinModelPortal	P0A7J6.
SMR	P0A7J6. Positions 1-162.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000087173; EBESCP00000083995; EBESCG00000086218. EBESCT00000092045; EBESCP00000088681; EBESCG00000091089.
GeneID	1025180. 1079897.
GenomeReviews	Gene locus SF4058 in contig AE005674_GR. Gene locus S3677 in contig AE014073_GR.
KEGG	sfl:SF4058. sfx:S3677.
PATRIC	18709178. VBIShiFle31049_4023.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000010118.
HOGENOM	HBG597359.
OMA	ANDKFEI.
ProtClustDB	PRK00099.
Enzyme and pathway databases
BioCyc	SFLE198214:AAN45487.1-MONOMER.
Family and domain databases
HAMAP	MF_00362. Ribosomal_L10. [Tree]
InterPro	IPR022973. Ribosomal_L10. IPR001790. Ribosomal_L10/acidic_P0. IPR002363. Ribosomal_L10_eubac_CS. [Graphical view]
KO	K02864.
Pfam	PF00466. Ribosomal_L10. 1 hit. [Graphical view]
PROSITE	PS01109. RIBOSOMAL_L10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00314. Capreomycin. DB00446. Chloramphenicol. DB01211. Clarithromycin. DB01190. Clindamycin. DB00254. Doxycycline. DB01321. Josamycin. DB01627. Lincomycin. DB00931. Methacycline. DB00778. Roxithromycin.

Entry information

Entry name

RL10_SHIFL

Accession

Primary (citable) accession number: P0A7J6
Secondary accession number(s): P02408

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program