P0A7H6 (RECR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Recombination protein recR

Gene names

Name:	recR
Ordered Locus Names:	b0472, JW0461

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a role in DNA repair. It seems to be involved in an recBC-independent recombinational process of DNA repair. It may act with recF and recO. HAMAP MF_00017
Sequence similarities	Belongs to the recR family. Contains 1 Toprim domain.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA synthesis involved in DNA repair Inferred from mutant phenotype. Source: EcoliWiki response to UV Inferred from mutant phenotype. Source: EcoliWiki
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Recombination protein recR HAMAP MF_00017		PRO_0000190316
Regions
	Domain	81 – 174	94	Toprim
	Zinc finger	57 – 72	16	C4-type Potential
Experimental info
	Sequence conflict	32	1	L → V in AAA23459. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0A7H6 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: F527EE1C809E47E9	FASTA	201	21,963
	10 20 30 40 50 60 MQTSPLLTQL MEALRCLPGV GPKSAQRMAF TLLQRDRSGG MRLAQALTRA MSEIGHCADC 70 80 90 100 110 120 RTFTEQEVCN ICSNPRRQEN GQICVVESPA DIYAIEQTGQ FSGRYFVLMG HLSPLDGIGP 130 140 150 160 170 180 DDIGLDRLEQ RLAEEKITEV ILATNPTVEG EATANYIAEL CAQYDVEASR IAHGVPVGGE 190 200 LEMVDGTTLS HSLAGRHKIR F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and expression of the Escherichia coli recR locus." Yeung T., Mullin D.A., Chen K.S., Craig E.A., Bardwell J.C.A., Walker J.R. J. Bacteriol. 172:6042-6047(1990) [PubMed: 1698765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"The recR locus of Escherichia coli K-12: molecular cloning, DNA sequencing and identification of the gene product." Mahdi A.A., Lloyd R.G. Nucleic Acids Res. 17:6781-6794(1989) [PubMed: 2674903] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[3]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15761 Genomic DNA. Translation: CAA33768.1. M38777 Genomic DNA. Translation: AAA23459.1. U82664 Genomic DNA. Translation: AAB40226.1. U00096 Genomic DNA. Translation: AAC73574.1. AP009048 Genomic DNA. Translation: BAE76251.1.
PIR	BVECRR. JU0106.
RefSeq	NP_415005.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P0A7H6.
SMR	P0A7H6. Positions 1-200.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0A7H6. 5 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000003211; EBESCP00000003211; EBESCG00000002636. EBESCT00000014377; EBESCP00000013668; EBESCG00000013438.
GeneID	945100.
GenomeReviews	Gene locus JW0461 in contig AP009048_GR. Gene locus b0472 in contig U00096_GR.
KEGG	ecj:JW0461. eco:b0472.
PATRIC	32116101. VBIEscCol129921_0492.
Organism-specific databases
EchoBASE	EB0827.
EcoGene	EG10834. recR.
Phylogenomic databases
eggNOG	COG0353.
GeneTree	EBGT00050000011882.
HOGENOM	HBG571744.
OMA	ILATDPN.
PhylomeDB	P0A7H6.
ProtClustDB	PRK00076.
Enzyme and pathway databases
BioCyc	EcoCyc:EG10834-MONOMER. MetaCyc:EG10834-MONOMER.
Gene expression databases
Genevestigator	P0A7H6.
Family and domain databases
HAMAP	MF_00017. RecR. [Tree]
InterPro	IPR000093. DNA_Rcmb_RecR. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR023627. Rcmb_RecR. IPR023628. Rcmb_RecR_C4-type_Zn. IPR015967. Rcmb_RecR_CS. IPR006171. Toprim_domain. [Graphical view]
KO	K06187.
Pfam	PF02132. RecR. 1 hit. PF01751. Toprim. 1 hit. [Graphical view]
SMART	SM00278. HhH1. 1 hit. SM00493. TOPRIM. 1 hit. [Graphical view]
SUPFAM	SSF111304. RecR. 1 hit.
TIGRFAMs	TIGR00615. RecR. 1 hit.
PROSITE	PS01300. RECR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RECR_ECOLI

Accession

Primary (citable) accession number: P0A7H6
Secondary accession number(s): P12727, Q2MBV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program