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P0A7C6

- PEPE_ECOLI

UniProt

P0A7C6 - PEPE_ECOLI

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Protein

Peptidase E

Gene

pepE

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.UniRule annotation

Catalytic activityi

Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei120 – 1201Charge relay systemUniRule annotation
Active sitei135 – 1351Charge relay systemUniRule annotation
Active sitei157 – 1571Charge relay systemUniRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-HAMAP
  2. peptidase activity Source: EcoCyc
  3. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciEcoCyc:EG11920-MONOMER.
ECOL316407:JW3981-MONOMER.
MetaCyc:EG11920-MONOMER.

Protein family/group databases

MEROPSiS51.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase EUniRule annotation (EC:3.4.13.21UniRule annotation)
Alternative name(s):
Alpha-aspartyl dipeptidaseUniRule annotation
Asp-specific dipeptidaseUniRule annotation
Dipeptidase EUniRule annotation
Gene namesi
Name:pepEUniRule annotation
Ordered Locus Names:b4021, JW3981
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11920. pepE.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Peptidase EPRO_0000209955Add
BLAST

Proteomic databases

PaxDbiP0A7C6.
PRIDEiP0A7C6.

Expressioni

Gene expression databases

GenevestigatoriP0A7C6.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
pepBP370951EBI-555623,EBI-549539

Protein-protein interaction databases

DIPiDIP-48072N.
IntActiP0A7C6. 4 interactions.
MINTiMINT-1236370.
STRINGi511145.b4021.

Structurei

3D structure databases

ProteinModelPortaliP0A7C6.
SMRiP0A7C6. Positions 1-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S51 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3340.
HOGENOMiHOG000281834.
InParanoidiP0A7C6.
KOiK05995.
OMAiHFISGKM.
OrthoDBiEOG6M6JST.
PhylomeDBiP0A7C6.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00510. Peptidase_E.
InterProiIPR029062. Class_I_gatase-like.
IPR005320. Peptidase_S51.
IPR023172. Peptidase_S51_dipeptidase-E.
[Graphical view]
PfamiPF03575. Peptidase_S51. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A7C6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLLLSNST LPGKAWLEHA LPLIAEQLQG RRSAVFIPFA GVTQTWDDYT
60 70 80 90 100
AKTAAVLAPL GVSVTGIHSV VDPVAAIENA EIVIVGGGNT FQLLKQCRER
110 120 130 140 150
GLLAPITDVV KRGALYIGWS AGANLACPTI RTTNDMPIVD PQGFDALNLF
160 170 180 190 200
PLQINPHFTN ALPEGHKGET REQRIRELLV VAPELTIIGL PEGNWITVSK
210 220
GHATLGGPNT TYVFKAGEEA VPLEAGHRF
Length:229
Mass (Da):24,570
Last modified:June 7, 2005 - v1
Checksum:i53D4D8395DFC63FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00006 Genomic DNA. Translation: AAC43115.1.
U00096 Genomic DNA. Translation: AAC76991.1.
AP009048 Genomic DNA. Translation: BAE78023.1.
PIRiD65209.
RefSeqiNP_418445.1. NC_000913.3.
YP_492164.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC76991; AAC76991; b4021.
BAE78023; BAE78023; BAE78023.
GeneIDi12933661.
948520.
KEGGiecj:Y75_p3908.
eco:b4021.
PATRICi32123571. VBIEscCol129921_4134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00006 Genomic DNA. Translation: AAC43115.1 .
U00096 Genomic DNA. Translation: AAC76991.1 .
AP009048 Genomic DNA. Translation: BAE78023.1 .
PIRi D65209.
RefSeqi NP_418445.1. NC_000913.3.
YP_492164.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0A7C6.
SMRi P0A7C6. Positions 1-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48072N.
IntActi P0A7C6. 4 interactions.
MINTi MINT-1236370.
STRINGi 511145.b4021.

Protein family/group databases

MEROPSi S51.001.

Proteomic databases

PaxDbi P0A7C6.
PRIDEi P0A7C6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC76991 ; AAC76991 ; b4021 .
BAE78023 ; BAE78023 ; BAE78023 .
GeneIDi 12933661.
948520.
KEGGi ecj:Y75_p3908.
eco:b4021.
PATRICi 32123571. VBIEscCol129921_4134.

Organism-specific databases

EchoBASEi EB1864.
EcoGenei EG11920. pepE.

Phylogenomic databases

eggNOGi COG3340.
HOGENOMi HOG000281834.
InParanoidi P0A7C6.
KOi K05995.
OMAi HFISGKM.
OrthoDBi EOG6M6JST.
PhylomeDBi P0A7C6.

Enzyme and pathway databases

BioCyci EcoCyc:EG11920-MONOMER.
ECOL316407:JW3981-MONOMER.
MetaCyc:EG11920-MONOMER.

Miscellaneous databases

PROi P0A7C6.

Gene expression databases

Genevestigatori P0A7C6.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
HAMAPi MF_00510. Peptidase_E.
InterProi IPR029062. Class_I_gatase-like.
IPR005320. Peptidase_S51.
IPR023172. Peptidase_S51_dipeptidase-E.
[Graphical view ]
Pfami PF03575. Peptidase_S51. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
    Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
    Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiPEPE_ECOLI
AccessioniPrimary (citable) accession number: P0A7C6
Secondary accession number(s): P32666, Q2M6T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3