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Protein

Peptidase E

Gene

pepE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.UniRule annotation

Catalytic activityi

Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei120Charge relay systemUniRule annotation1
Active sitei135Charge relay systemUniRule annotation1
Active sitei157Charge relay systemUniRule annotation1

GO - Molecular functioni

  • dipeptidase activity Source: UniProtKB-KW
  • peptidase activity Source: EcoCyc
  • serine-type peptidase activity Source: UniProtKB-KW

Keywordsi

Molecular functionDipeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciEcoCyc:EG11920-MONOMER.
MetaCyc:EG11920-MONOMER.

Protein family/group databases

MEROPSiS51.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase EUniRule annotation (EC:3.4.13.21UniRule annotation)
Alternative name(s):
Alpha-aspartyl dipeptidaseUniRule annotation
Asp-specific dipeptidaseUniRule annotation
Dipeptidase EUniRule annotation
Gene namesi
Name:pepEUniRule annotation
Ordered Locus Names:b4021, JW3981
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11920. pepE.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099551 – 229Peptidase EAdd BLAST229

Proteomic databases

PaxDbiP0A7C6.
PRIDEiP0A7C6.

Interactioni

Protein-protein interaction databases

BioGridi4262655. 23 interactors.
DIPiDIP-48072N.
IntActiP0A7C6. 4 interactors.
MINTiMINT-1236370.
STRINGi316385.ECDH10B_4210.

Structurei

3D structure databases

ProteinModelPortaliP0A7C6.
SMRiP0A7C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S51 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQ6. Bacteria.
COG3340. LUCA.
HOGENOMiHOG000281834.
InParanoidiP0A7C6.
KOiK05995.
PhylomeDBiP0A7C6.

Family and domain databases

CDDicd03146. GAT1_Peptidase_E. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00510. Peptidase_E. 1 hit.
InterProiView protein in InterPro
IPR029062. Class_I_gatase-like.
IPR005320. Peptidase_S51.
IPR023172. Peptidase_S51_dipeptidase-E.
PfamiView protein in Pfam
PF03575. Peptidase_S51. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A7C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLLLSNST LPGKAWLEHA LPLIAEQLQG RRSAVFIPFA GVTQTWDDYT
60 70 80 90 100
AKTAAVLAPL GVSVTGIHSV VDPVAAIENA EIVIVGGGNT FQLLKQCRER
110 120 130 140 150
GLLAPITDVV KRGALYIGWS AGANLACPTI RTTNDMPIVD PQGFDALNLF
160 170 180 190 200
PLQINPHFTN ALPEGHKGET REQRIRELLV VAPELTIIGL PEGNWITVSK
210 220
GHATLGGPNT TYVFKAGEEA VPLEAGHRF
Length:229
Mass (Da):24,570
Last modified:June 7, 2005 - v1
Checksum:i53D4D8395DFC63FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43115.1.
U00096 Genomic DNA. Translation: AAC76991.1.
AP009048 Genomic DNA. Translation: BAE78023.1.
PIRiD65209.
RefSeqiNP_418445.1. NC_000913.3.
WP_000421763.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76991; AAC76991; b4021.
BAE78023; BAE78023; BAE78023.
GeneIDi948520.
KEGGiecj:JW3981.
eco:b4021.
PATRICifig|1411691.4.peg.2692.

Similar proteinsi

Entry informationi

Entry nameiPEPE_ECOLI
AccessioniPrimary (citable) accession number: P0A7C6
Secondary accession number(s): P32666, Q2M6T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 27, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families