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P0A7C6

- PEPE_ECOLI

UniProt

P0A7C6 - PEPE_ECOLI

Protein

Peptidase E

Gene

pepE

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.UniRule annotation

    Catalytic activityi

    Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei120 – 1201Charge relay systemUniRule annotation
    Active sitei135 – 1351Charge relay systemUniRule annotation
    Active sitei157 – 1571Charge relay systemUniRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-HAMAP
    2. peptidase activity Source: EcoCyc
    3. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BioCyciEcoCyc:EG11920-MONOMER.
    ECOL316407:JW3981-MONOMER.
    MetaCyc:EG11920-MONOMER.

    Protein family/group databases

    MEROPSiS51.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase EUniRule annotation (EC:3.4.13.21UniRule annotation)
    Alternative name(s):
    Alpha-aspartyl dipeptidaseUniRule annotation
    Asp-specific dipeptidaseUniRule annotation
    Dipeptidase EUniRule annotation
    Gene namesi
    Name:pepEUniRule annotation
    Ordered Locus Names:b4021, JW3981
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11920. pepE.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Peptidase EPRO_0000209955Add
    BLAST

    Proteomic databases

    PaxDbiP0A7C6.
    PRIDEiP0A7C6.

    Expressioni

    Gene expression databases

    GenevestigatoriP0A7C6.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    pepBP370951EBI-555623,EBI-549539

    Protein-protein interaction databases

    DIPiDIP-48072N.
    IntActiP0A7C6. 4 interactions.
    MINTiMINT-1236370.
    STRINGi511145.b4021.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A7C6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S51 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3340.
    HOGENOMiHOG000281834.
    KOiK05995.
    OMAiHFISGKM.
    OrthoDBiEOG6M6JST.
    PhylomeDBiP0A7C6.

    Family and domain databases

    Gene3Di3.40.50.880. 1 hit.
    HAMAPiMF_00510. Peptidase_E.
    InterProiIPR029062. Class_I_gatase-like.
    IPR005320. Peptidase_S51.
    IPR023172. Peptidase_S51_dipeptidase-E.
    [Graphical view]
    PfamiPF03575. Peptidase_S51. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A7C6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLLLSNST LPGKAWLEHA LPLIAEQLQG RRSAVFIPFA GVTQTWDDYT    50
    AKTAAVLAPL GVSVTGIHSV VDPVAAIENA EIVIVGGGNT FQLLKQCRER 100
    GLLAPITDVV KRGALYIGWS AGANLACPTI RTTNDMPIVD PQGFDALNLF 150
    PLQINPHFTN ALPEGHKGET REQRIRELLV VAPELTIIGL PEGNWITVSK 200
    GHATLGGPNT TYVFKAGEEA VPLEAGHRF 229
    Length:229
    Mass (Da):24,570
    Last modified:June 7, 2005 - v1
    Checksum:i53D4D8395DFC63FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00006 Genomic DNA. Translation: AAC43115.1.
    U00096 Genomic DNA. Translation: AAC76991.1.
    AP009048 Genomic DNA. Translation: BAE78023.1.
    PIRiD65209.
    RefSeqiNP_418445.1. NC_000913.3.
    YP_492164.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76991; AAC76991; b4021.
    BAE78023; BAE78023; BAE78023.
    GeneIDi12933661.
    948520.
    KEGGiecj:Y75_p3908.
    eco:b4021.
    PATRICi32123571. VBIEscCol129921_4134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00006 Genomic DNA. Translation: AAC43115.1 .
    U00096 Genomic DNA. Translation: AAC76991.1 .
    AP009048 Genomic DNA. Translation: BAE78023.1 .
    PIRi D65209.
    RefSeqi NP_418445.1. NC_000913.3.
    YP_492164.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0A7C6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48072N.
    IntActi P0A7C6. 4 interactions.
    MINTi MINT-1236370.
    STRINGi 511145.b4021.

    Protein family/group databases

    MEROPSi S51.001.

    Proteomic databases

    PaxDbi P0A7C6.
    PRIDEi P0A7C6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76991 ; AAC76991 ; b4021 .
    BAE78023 ; BAE78023 ; BAE78023 .
    GeneIDi 12933661.
    948520.
    KEGGi ecj:Y75_p3908.
    eco:b4021.
    PATRICi 32123571. VBIEscCol129921_4134.

    Organism-specific databases

    EchoBASEi EB1864.
    EcoGenei EG11920. pepE.

    Phylogenomic databases

    eggNOGi COG3340.
    HOGENOMi HOG000281834.
    KOi K05995.
    OMAi HFISGKM.
    OrthoDBi EOG6M6JST.
    PhylomeDBi P0A7C6.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG11920-MONOMER.
    ECOL316407:JW3981-MONOMER.
    MetaCyc:EG11920-MONOMER.

    Miscellaneous databases

    PROi P0A7C6.

    Gene expression databases

    Genevestigatori P0A7C6.

    Family and domain databases

    Gene3Di 3.40.50.880. 1 hit.
    HAMAPi MF_00510. Peptidase_E.
    InterProi IPR029062. Class_I_gatase-like.
    IPR005320. Peptidase_S51.
    IPR023172. Peptidase_S51_dipeptidase-E.
    [Graphical view ]
    Pfami PF03575. Peptidase_S51. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
      Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
      Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiPEPE_ECOLI
    AccessioniPrimary (citable) accession number: P0A7C6
    Secondary accession number(s): P32666, Q2M6T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3