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P0A793

- PAND_SHIFL

UniProt

P0A793 - PAND_SHIFL

Protein

Aspartate 1-decarboxylase

Gene

panD

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.UniRule annotation

    Catalytic activityi

    L-aspartate = beta-alanine + CO2.UniRule annotation

    Cofactori

    Pyruvoyl group.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation
    Binding sitei57 – 571SubstrateUniRule annotation
    Active sitei58 – 581Proton donorUniRule annotation

    GO - Molecular functioni

    1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. alanine biosynthetic process Source: InterPro
    2. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    Pyruvate, Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate 1-decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
    Alternative name(s):
    Aspartate alpha-decarboxylaseUniRule annotation
    Cleaved into the following 2 chains:
    Aspartate 1-decarboxylase beta chainUniRule annotation
    Aspartate 1-decarboxylase alpha chainUniRule annotation
    Gene namesi
    Name:panDUniRule annotation
    Ordered Locus Names:SF0128, S0130
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2424Aspartate 1-decarboxylase beta chainUniRule annotationPRO_0000023155Add
    BLAST
    Chaini25 – 126102Aspartate 1-decarboxylase alpha chainUniRule annotationPRO_0000023156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Pyruvic acid (Ser)UniRule annotation

    Post-translational modificationi

    Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.UniRule annotation

    Keywords - PTMi

    Autocatalytic cleavage, Zymogen

    Proteomic databases

    PaxDbiP0A793.
    PRIDEiP0A793.

    Interactioni

    Subunit structurei

    Heterooctamer of four alpha and four beta subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi198214.SF0128.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A793.
    SMRiP0A793. Positions 25-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 753Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PanD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0853.
    HOGENOMiHOG000221007.
    KOiK01579.
    OrthoDBiEOG6P5ZMC.

    Family and domain databases

    HAMAPiMF_00446. PanD.
    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view]
    PANTHERiPTHR21012. PTHR21012. 1 hit.
    PfamiPF02261. Asp_decarbox. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
    ProDomiPD009294. Asp_decarbox. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    TIGRFAMsiTIGR00223. panD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A793-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRTMLQGKL HRVKVTHADL HYEGSCAIDQ DFLDAAGILE NEAIDIWNVT    50
    NGKRFSTYAI AAERGSRIIS VNGAAAHCAS VGDIVIIASF VTMPDEEART 100
    WRPNVAYFEG DNEMKRTAKA IPVQVA 126
    Length:126
    Mass (Da):13,834
    Last modified:June 7, 2005 - v1
    Checksum:iE3169F5C2BDD5D25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN41791.2.
    AE014073 Genomic DNA. Translation: AAP15672.1.
    RefSeqiNP_706084.2. NC_004337.2.
    NP_835867.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN41791; AAN41791; SF0128.
    AAP15672; AAP15672; S0130.
    GeneIDi1024489.
    1076562.
    KEGGisfl:SF0128.
    sfx:S0130.
    PATRICi18701202. VBIShiFle31049_0143.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN41791.2 .
    AE014073 Genomic DNA. Translation: AAP15672.1 .
    RefSeqi NP_706084.2. NC_004337.2.
    NP_835867.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P0A793.
    SMRi P0A793. Positions 25-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF0128.

    Proteomic databases

    PaxDbi P0A793.
    PRIDEi P0A793.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN41791 ; AAN41791 ; SF0128 .
    AAP15672 ; AAP15672 ; S0130 .
    GeneIDi 1024489.
    1076562.
    KEGGi sfl:SF0128.
    sfx:S0130.
    PATRICi 18701202. VBIShiFle31049_0143.

    Phylogenomic databases

    eggNOGi COG0853.
    HOGENOMi HOG000221007.
    KOi K01579.
    OrthoDBi EOG6P5ZMC.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00002 .

    Family and domain databases

    HAMAPi MF_00446. PanD.
    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view ]
    PANTHERi PTHR21012. PTHR21012. 1 hit.
    Pfami PF02261. Asp_decarbox. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
    ProDomi PD009294. Asp_decarbox. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    TIGRFAMsi TIGR00223. panD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiPAND_SHIFL
    AccessioniPrimary (citable) accession number: P0A793
    Secondary accession number(s): P31664, Q8KMY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3