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Protein

Protein NrdI

Gene

nrdI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in ribonucleotide reductase function.By similarity

GO - Molecular functioni

  • FMN binding Source: EcoCyc

GO - Biological processi

  • cellular protein modification process Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7402-MONOMER.
ECOL316407:JW2649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NrdI
Gene namesi
Name:nrdI
Synonyms:ygaO
Ordered Locus Names:b2674, JW2649
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13287. nrdI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Protein NrdIPRO_0000164314Add
BLAST

Proteomic databases

PaxDbiP0A772.
PRIDEiP0A772.

Expressioni

Inductioni

Induced 2-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262268. 9 interactions.
IntActiP0A772. 26 interactions.
STRINGi511145.b2674.

Structurei

Secondary structure

1
136
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Helixi13 – 219Combined sources
Beta strandi25 – 273Combined sources
Beta strandi30 – 334Combined sources
Beta strandi42 – 476Combined sources
Beta strandi52 – 587Combined sources
Helixi60 – 667Combined sources
Helixi69 – 746Combined sources
Beta strandi75 – 828Combined sources
Helixi84 – 896Combined sources
Helixi92 – 10110Combined sources
Beta strandi105 – 1106Combined sources
Helixi115 – 13016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N39X-ray2.50C/D1-133[»]
3N3AX-ray1.99C/D1-133[»]
3N3BX-ray2.36C/D1-133[»]
ProteinModelPortaliP0A772.
SMRiP0A772. Positions 3-133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A772.

Family & Domainsi

Sequence similaritiesi

Belongs to the NrdI family.Curated

Phylogenomic databases

eggNOGiENOG4105G3E. Bacteria.
COG1780. LUCA.
HOGENOMiHOG000246177.
InParanoidiP0A772.
KOiK03647.
OMAiNTHRFVG.
OrthoDBiEOG6W19RD.
PhylomeDBiP0A772.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_00128. NrdI.
InterProiIPR029039. Flavoprotein-like_dom.
IPR020852. RNR_Ib_NrdI_bac.
IPR004465. RNR_NrdI.
[Graphical view]
PfamiPF07972. Flavodoxin_NdrI. 1 hit.
[Graphical view]
PIRSFiPIRSF005087. NrdI. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR00333. nrdI. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLVYFSSS SENTQRFIER LGLPAVRIPL NERERIQVDE PYILIVPSYG
60 70 80 90 100
GGGTAGAVPR QVIRFLNDEH NRALLRGVIA SGNRNFGEAY GRAGDVIARK
110 120 130
CGVPWLYRFE LMGTQSDIEN VRKGVTEFWQ RQPQNA
Length:136
Mass (Da):15,340
Last modified:June 7, 2005 - v1
Checksum:i2834D808D18EBCBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79787 Genomic DNA. Translation: CAA56185.1.
U00096 Genomic DNA. Translation: AAC75721.1.
AP009048 Genomic DNA. Translation: BAA16538.2.
PIRiS70890.
RefSeqiNP_417160.1. NC_000913.3.
WP_000080947.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75721; AAC75721; b2674.
BAA16538; BAA16538; BAA16538.
GeneIDi947158.
KEGGiecj:JW2649.
eco:b2674.
PATRICi32120738. VBIEscCol129921_2766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79787 Genomic DNA. Translation: CAA56185.1.
U00096 Genomic DNA. Translation: AAC75721.1.
AP009048 Genomic DNA. Translation: BAA16538.2.
PIRiS70890.
RefSeqiNP_417160.1. NC_000913.3.
WP_000080947.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N39X-ray2.50C/D1-133[»]
3N3AX-ray1.99C/D1-133[»]
3N3BX-ray2.36C/D1-133[»]
ProteinModelPortaliP0A772.
SMRiP0A772. Positions 3-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262268. 9 interactions.
IntActiP0A772. 26 interactions.
STRINGi511145.b2674.

Proteomic databases

PaxDbiP0A772.
PRIDEiP0A772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75721; AAC75721; b2674.
BAA16538; BAA16538; BAA16538.
GeneIDi947158.
KEGGiecj:JW2649.
eco:b2674.
PATRICi32120738. VBIEscCol129921_2766.

Organism-specific databases

EchoBASEiEB3072.
EcoGeneiEG13287. nrdI.

Phylogenomic databases

eggNOGiENOG4105G3E. Bacteria.
COG1780. LUCA.
HOGENOMiHOG000246177.
InParanoidiP0A772.
KOiK03647.
OMAiNTHRFVG.
OrthoDBiEOG6W19RD.
PhylomeDBiP0A772.

Enzyme and pathway databases

BioCyciEcoCyc:G7402-MONOMER.
ECOL316407:JW2649-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A772.
PROiP0A772.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_00128. NrdI.
InterProiIPR029039. Flavoprotein-like_dom.
IPR020852. RNR_Ib_NrdI_bac.
IPR004465. RNR_NrdI.
[Graphical view]
PfamiPF07972. Flavodoxin_NdrI. 1 hit.
[Graphical view]
PIRSFiPIRSF005087. NrdI. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR00333. nrdI. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Promoter identification and expression analysis of Salmonella typhimurium and Escherichia coli nrdEF operons encoding one of two class I ribonucleotide reductases present in both bacteria."
    Jordan A., Aragall E., Gibert I., Barbe J.
    Mol. Microbiol. 19:777-790(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli."
    Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J., Walker G.C.
    Mol. Cell 36:845-860(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HYDROXYUREA.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Entry informationi

Entry nameiNRDI_ECOLI
AccessioniPrimary (citable) accession number: P0A772
Secondary accession number(s): P77025, Q47415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: January 20, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.