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P0A764 (NDK_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nucleoside diphosphate kinase
Short name=NDK
Short name=NDP kinase
EC=2.7.4.6
Alternative name(s):
Nucleoside-2-P kinase
Gene names
Name:ndk
Ordered Locus Names:Z3781, ECs3380
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length143 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. HAMAP MF_00451

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP MF_00451

Cofactor

Magnesium By similarity. HAMAP MF_00451

Subunit structure

Homotetramer By similarity. HAMAP MF_00451

Subcellular location

Cytoplasm By similarity HAMAP MF_00451.

Sequence similarities

Belongs to the NDK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 143142Nucleoside diphosphate kinase HAMAP MF_00451
PRO_0000136979

Sites

Active site1171Pros-phosphohistidine intermediate
Binding site111ATP By similarity
Binding site591ATP By similarity
Binding site871ATP By similarity
Binding site931ATP By similarity
Binding site1041ATP By similarity
Binding site1141ATP By similarity

Amino acid modifications

Modified residue1191Phosphoserine By similarity
Modified residue1211Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A764 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 8C069C10043532EC

FASTA14315,463
        10         20         30         40         50         60 
MAIERTFSII KPNAVAKNVI GNIFARFEAA GFKIVGTKML HLTVEQARGF YAEHDGKPFF 

        70         80         90        100        110        120 
DGLVEFMTSG PIVVSVLEGE NAVQRHRDLL GATNPANALA GTLRADYADS LTENGTHGSD 

       130        140 
SVESAAREIA YFFGEGEVCP RTR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG57628.1.
BA000007 Genomic DNA. Translation: BAB36803.1.
PIRD91051.
H85895.
RefSeqNP_289071.1. NC_002655.2.
NP_311407.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0A764.
SMRP0A764. Positions 2-143.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1255767.

Proteomic databases

PRIDEP0A764.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000024546; EBESCP00000023439; EBESCG00000023600.
EBESCT00000056437; EBESCP00000054265; EBESCG00000055485.
GeneID915205.
957806.
GenomeReviewsGene locus Z3781 in contig AE005174_GR.
Gene locus ECs3380 in contig BA000007_GR.
KEGGece:Z3781.
ecs:ECs3380.
PATRIC18356188. VBIEscCol44059_3289.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000009590.
HOGENOMHBG445152.
OMAERPFFGA.
ProtClustDBPRK00668.

Enzyme and pathway databases

BioCycECOL83334:ECS3380-MONOMER.

Family and domain databases

HAMAPMF_00451. NDP_kinase.
[Tree]
InterProIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
Gene3DG3DSA:3.30.70.141. NDK. 1 hit.
KOK00940.
PANTHERPTHR11349. Nuc_diP_kinase_core. 1 hit.
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
SMARTSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMSSF54919. NDK. 1 hit.
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDK_ECO57
AccessionPrimary (citable) accession number: P0A764
Secondary accession number(s): P24233
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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