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Protein

Glutathione-regulated potassium-efflux system ancillary protein KefG

Gene

kefG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.UniRule annotation1 Publication

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:G7717-MONOMER.
ECOL316407:JW3314-MONOMER.

Protein family/group databases

TCDBi2.A.37.1.2. the monovalent cation:proton antiporter-2 (cpa2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione-regulated potassium-efflux system ancillary protein KefGUniRule annotation
Alternative name(s):
Putative quinone oxidoreductase KefGUniRule annotation (EC:1.6.5.2UniRule annotation)
Gene namesi
Name:kefGUniRule annotation
Synonyms:yheR
Ordered Locus Names:b3351, JW3314
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12902. kefG.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Glutathione-regulated potassium-efflux system ancillary protein KefGPRO_0000071642Add
BLAST

Proteomic databases

PaxDbiP0A756.
PRIDEiP0A756.

Interactioni

Subunit structurei

Interacts with KefB.UniRule annotation

Protein-protein interaction databases

BioGridi4263025. 11 interactions.
IntActiP0A756. 6 interactions.
STRINGi511145.b3351.

Structurei

3D structure databases

ProteinModelPortaliP0A756.
SMRiP0A756. Positions 8-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108K2R. Bacteria.
COG2249. LUCA.
HOGENOMiHOG000149972.
InParanoidiP0A756.
KOiK11748.
OMAiRYPMSDI.
PhylomeDBiP0A756.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSQPAKVLL LYAHPESQDS VANRVLLKPA TQLSNVTVHD LYAHYPDFFI
60 70 80 90 100
DIPREQALLR EHEVIVFQHP LYTYSCPALL KEWLDRVLSR GFASGPGGNQ
110 120 130 140 150
LAGKYWRSVI TTGEPESAYR YDALNRYPMS DVLRPFELAA GMCRMHWLSP
160 170 180
IIIYWARRQS AQELASHARA YGDWLANPLS PGGR
Length:184
Mass (Da):20,958
Last modified:June 7, 2005 - v1
Checksum:iF3B1123F7378EAB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58148.1.
U00096 Genomic DNA. Translation: AAC76376.1.
AP009048 Genomic DNA. Translation: BAE77939.1.
PIRiB65129.
RefSeqiNP_417810.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76376; AAC76376; b3351.
BAE77939; BAE77939; BAE77939.
GeneIDi947857.
KEGGiecj:JW3314.
eco:b3351.
PATRICi32122136. VBIEscCol129921_3445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58148.1.
U00096 Genomic DNA. Translation: AAC76376.1.
AP009048 Genomic DNA. Translation: BAE77939.1.
PIRiB65129.
RefSeqiNP_417810.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0A756.
SMRiP0A756. Positions 8-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263025. 11 interactions.
IntActiP0A756. 6 interactions.
STRINGi511145.b3351.

Protein family/group databases

TCDBi2.A.37.1.2. the monovalent cation:proton antiporter-2 (cpa2) family.

Proteomic databases

PaxDbiP0A756.
PRIDEiP0A756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76376; AAC76376; b3351.
BAE77939; BAE77939; BAE77939.
GeneIDi947857.
KEGGiecj:JW3314.
eco:b3351.
PATRICi32122136. VBIEscCol129921_3445.

Organism-specific databases

EchoBASEiEB2739.
EcoGeneiEG12902. kefG.

Phylogenomic databases

eggNOGiENOG4108K2R. Bacteria.
COG2249. LUCA.
HOGENOMiHOG000149972.
InParanoidiP0A756.
KOiK11748.
OMAiRYPMSDI.
PhylomeDBiP0A756.

Enzyme and pathway databases

BioCyciEcoCyc:G7717-MONOMER.
ECOL316407:JW3314-MONOMER.

Miscellaneous databases

PROiP0A756.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKEFG_ECOLI
AccessioniPrimary (citable) accession number: P0A756
Secondary accession number(s): P45534, Q2M717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.