ID   MSRB_ECOL6              Reviewed;         137 AA.
AC   P0A747; P39903; P76232; P76912;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrB;
DE            EC=1.8.4.12;
DE   AltName: Full=Peptide-methionine (R)-S-oxide reductase;
GN   Name=msrB; OrderedLocusNames=c2183;
OS   Escherichia coli O6.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=217992;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O6:H1 / CFT073 / ATCC 700928 / UPEC;
RX   MEDLINE=22388234; PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA   Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA   Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA   Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence
RT   of uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit. The zinc ion is important
CC       for the structural integrity of the protein (By similarity).
CC   -!- SIMILARITY: Belongs to the msrB Met sulfoxide reductase family.
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DR   EMBL; AE014075; AAN80642.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_754077.1; -.
DR   HSSP; P14930; 1L1D.
DR   GeneID; 1036623; -.
DR   GenomeReviews; AE014075_GR; c2183.
DR   KEGG; ecc:c2183; -.
DR   HOGENOM; P0A747; -.
DR   OMA; P0A747; FTGRYWD.
DR   BRENDA; 1.8.4.12; 292881.
DR   GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase ac...; IEA:EC.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01400; -; 1.
DR   InterPro; IPR002579; Methionine_sulphoxide_MsrB.
DR   Gene3D; G3DSA:2.170.150.20; MsrB; 1.
DR   Pfam; PF01641; SelR; 1.
DR   ProDom; PD004057; DUF25; 1.
DR   TIGRFAMs; TIGR00357; MsrB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; Oxidoreductase; Zinc.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    137       Peptide methionine sulfoxide reductase
FT                                msrB.
FT                                /FTId=PRO_0000140273.
FT   ACT_SITE    118    118       Nucleophile (By similarity).
FT   METAL        46     46       Zinc (By similarity).
FT   METAL        49     49       Zinc (By similarity).
FT   METAL        95     95       Zinc (By similarity).
FT   METAL        98     98       Zinc (By similarity).
SQ   SEQUENCE   137 AA;  15451 MW;  7B9B783DBEBE0F71 CRC64;
     MANKPSAEEL KKNLSEMQFY VTQNHGTEPP FTGRLLHNKR DGVYHCLICD APLFHSQTKY
     DSGCGWPSFY EPVSEESIRY IKDLSHGMQR IEIRCGNCDA HLGHVFPDGP QPTGERYCVN
     SASLRFTDGE NGEEING
//