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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46ZincPROSITE-ProRule annotation1
Metal bindingi49ZincPROSITE-ProRule annotation1
Metal bindingi95ZincPROSITE-ProRule annotation1
Metal bindingi98ZincPROSITE-ProRule annotation1
Active sitei118NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • iron ion binding Source: EcoliWiki
  • peptide-methionine (R)-S-oxide reductase activity Source: EcoliWiki
  • zinc ion binding Source: EcoliWiki

GO - Biological processi

  • protein repair Source: EcoCyc
  • response to oxidative stress Source: InterPro

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG12394-MONOMER
MetaCyc:EG12394-MONOMER
BRENDAi1.8.4.12 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrB (EC:1.8.4.12)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductase
Gene namesi
Name:msrB
Synonyms:yeaA
Ordered Locus Names:b1778, JW1767
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12394 msrB

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46C → D: Loss of activity; when associated with S-49; S-95 and S-98. 1 Publication1
Mutagenesisi49C → S: Loss of activity; when associated with S-46; S-95 and S-98. 1 Publication1
Mutagenesisi95C → S: Loss of activity; when associated with S-46; S-49 and S-98. 1 Publication1
Mutagenesisi98C → S: Loss of activity; when associated with S-46; S-49 and S-95. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001402712 – 137Peptide methionine sulfoxide reductase MsrBAdd BLAST136

Proteomic databases

PaxDbiP0A746
PRIDEiP0A746

Interactioni

Protein-protein interaction databases

BioGridi4260307, 54 interactors
DIPiDIP-48167N
IntActiP0A746, 4 interactors
STRINGi316385.ECDH10B_1916

Structurei

3D structure databases

ProteinModelPortaliP0A746
SMRiP0A746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 129MsrBPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E0X Bacteria
COG0229 LUCA
HOGENOMiHOG000243425
InParanoidiP0A746
KOiK07305
OMAiYKASHKF
PhylomeDBiP0A746

Family and domain databases

HAMAPiMF_01400 MsrB, 1 hit
InterProiView protein in InterPro
IPR028427 Met_Sox_Rdtase
IPR002579 Met_Sox_Rdtase_MsrB
IPR011057 Mss4-like_sf
PANTHERiPTHR10173 PTHR10173, 1 hit
PfamiView protein in Pfam
PF01641 SelR, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
TIGRFAMsiTIGR00357 TIGR00357, 1 hit
PROSITEiView protein in PROSITE
PS51790 MSRB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKPSAEEL KKNLSEMQFY VTQNHGTEPP FTGRLLHNKR DGVYHCLICD
60 70 80 90 100
APLFHSQTKY DSGCGWPSFY EPVSEESIRY IKDLSHGMQR IEIRCGNCDA
110 120 130
HLGHVFPDGP QPTGERYCVN SASLRFTDGE NGEEING
Length:137
Mass (Da):15,451
Last modified:June 7, 2005 - v1
Checksum:i7B9B783DBEBE0F71
GO

Sequence cautioni

The sequence X02662 differs from that shown. Reason: Frameshift at position 5.Curated

Mass spectrometryi

Molecular mass is 15319±1 Da from positions 2 - 137. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74848.1
AP009048 Genomic DNA Translation: BAA15575.2
X02662 Genomic DNA No translation available.
PIRiB64938
RefSeqiNP_416292.1, NC_000913.3
WP_001284618.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74848; AAC74848; b1778
BAA15575; BAA15575; BAA15575
GeneIDi947188
KEGGiecj:JW1767
eco:b1778
PATRICifig|1411691.4.peg.476

Similar proteinsi

Entry informationi

Entry nameiMSRB_ECOLI
AccessioniPrimary (citable) accession number: P0A746
Secondary accession number(s): P39903, P76232, P76912
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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