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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19SubstrateUniRule annotation1
Binding sitei23SubstrateUniRule annotation1
Active sitei71Proton donor/acceptorUniRule annotation1
Binding sitei98SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:SF0965, S1031
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

DrugBankiDB02726. 2-Phosphoglycolic Acid.
DB01942. Formic Acid.
DB03026. Phosphoglycolohydroxamic Acid.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001786461 – 152Methylglyoxal synthaseAdd BLAST152

Structurei

3D structure databases

ProteinModelPortaliP0A733.
SMRiP0A733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 152MGS-likeUniRule annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 48Substrate bindingUniRule annotation4
Regioni65 – 66Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4108Z5K. Bacteria.
COG1803. LUCA.
HOGENOMiHOG000283729.
KOiK01734.

Family and domain databases

CDDicd01422. MGS. 1 hit.
Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth. 1 hit.
InterProiView protein in InterPro
IPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
IPR036914. MGS-like_dom_sf.
PANTHERiPTHR30492. PTHR30492. 1 hit.
PfamiView protein in Pfam
PF02142. MGS. 1 hit.
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiView protein in SMART
SM00851. MGS. 1 hit.
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiView protein in PROSITE
PS01335. METHYLGLYOXAL_SYNTH. 1 hit.
PS51855. MGS. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTTRTLPA RKHIALVAHD HCKQMLMSWV ERHQPLLEQH VLYATGTTGN
60 70 80 90 100
LISRATGMNV NAMLSGPMGG DQQVGALISE GKIDVLIFFW DPLNAVPHDP
110 120 130 140 150
DVKALLRLAT VWNIPVATNV ATADFIIQSP HFNDAVDILI PDYQRYLADR

LK
Length:152
Mass (Da):16,919
Last modified:June 7, 2005 - v1
Checksum:i85157193BD4CE72D
GO

Sequence cautioni

The sequence AAN42593 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP16479 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN42593.1. Different initiation.
AE014073 Genomic DNA. Translation: AAP16479.1. Different initiation.
RefSeqiNP_706886.3. NC_004337.2.
WP_000424181.1. NZ_NIYV01000033.1.

Genome annotation databases

EnsemblBacteriaiAAN42593; AAN42593; SF0965.
AAP16479; AAP16479; S1031.
GeneIDi1023912.
KEGGisfl:SF0965.
sfx:S1031.
PATRICifig|198214.7.peg.1123.

Similar proteinsi

Entry informationi

Entry nameiMGSA_SHIFL
AccessioniPrimary (citable) accession number: P0A733
Secondary accession number(s): P37066
, P75872, Q8XD91, Q9R7Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome