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Protein

2-keto-3-deoxygluconate permease

Gene

kdgT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system.

GO - Molecular functioni

GO - Biological processi

  • gluconate transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:KDGT-MONOMER.
ECOL316407:JW5560-MONOMER.
MetaCyc:KDGT-MONOMER.

Protein family/group databases

TCDBi2.A.10.1.2. the 2-keto-3-deoxygluconate transporter (kdgt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
2-keto-3-deoxygluconate permease
Short name:
KDG permease
Gene namesi
Name:kdgT
Ordered Locus Names:b3909, JW5560
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11869. kdgT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 41PeriplasmicSequence analysisAdd BLAST11
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94PeriplasmicSequence analysis1
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 138CytoplasmicSequence analysisAdd BLAST23
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 162PeriplasmicSequence analysis3
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 198CytoplasmicSequence analysisAdd BLAST15
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 223PeriplasmicSequence analysis4
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 253CytoplasmicSequence analysis9
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 288PeriplasmicSequence analysisAdd BLAST14
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 327CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002096751 – 3272-keto-3-deoxygluconate permeaseAdd BLAST327

Proteomic databases

PaxDbiP0A712.
PRIDEiP0A712.

Interactioni

Protein-protein interaction databases

BioGridi4259555. 9 interactors.
STRINGi511145.b3909.

Structurei

3D structure databases

ProteinModelPortaliP0A712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdgT transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CAX. Bacteria.
ENOG410XNUJ. LUCA.
HOGENOMiHOG000221851.
InParanoidiP0A712.
KOiK02526.
OMAiESGPFMT.

Family and domain databases

HAMAPiMF_00070. KdgT. 1 hit.
InterProiIPR004684. 2keto-3dGluconate_permease.
IPR018395. 2keto-3dGluconate_permease_sub.
[Graphical view]
PfamiPF03812. KdgT. 1 hit.
[Graphical view]
ProDomiPD024513. 2keto-3dGluconate_permease. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00793. kdgT. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIKRSIEKI PGGMMLVPLF LGALCHTFSP GAGKYFGSFT NGMITGTVPI
60 70 80 90 100
LAVWFFCMGA SIKLSATGTV LRKSGTLVVT KIAVAWVVAA IASRIIPEHG
110 120 130 140 150
VEVGFFAGLS TLALVAAMDM TNGGLYASIM QQYGTKEEAG AFVLMSLESG
160 170 180 190 200
PLMTMIILGT AGIASFEPHV FVGAVLPFLV GFALGNLDPE LREFFSKAVQ
210 220 230 240 250
TLIPFFAFAL GNTIDLTVIA QTGLLGILLG VAVIIVTGIP LIIADKLIGG
260 270 280 290 300
GDGTAGIAAS SSAGAAVATP VLIAEMVPAF KPMAPAATSL VATAVIVTSI
310 320
LVPILTSIWS RKVKARAAKI EILGTVK
Length:327
Mass (Da):33,669
Last modified:June 7, 2005 - v1
Checksum:i8F870CB233B35453
GO

Sequence cautioni

The sequence AAB03042 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03042.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76891.2.
AP009048 Genomic DNA. Translation: BAE77400.1.
PIRiS40853.
RefSeqiNP_418345.2. NC_000913.3.
WP_001166063.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76891; AAC76891; b3909.
BAE77400; BAE77400; BAE77400.
GeneIDi948407.
KEGGiecj:JW5560.
eco:b3909.
PATRICi32123331. VBIEscCol129921_4026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03042.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76891.2.
AP009048 Genomic DNA. Translation: BAE77400.1.
PIRiS40853.
RefSeqiNP_418345.2. NC_000913.3.
WP_001166063.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259555. 9 interactors.
STRINGi511145.b3909.

Protein family/group databases

TCDBi2.A.10.1.2. the 2-keto-3-deoxygluconate transporter (kdgt) family.

Proteomic databases

PaxDbiP0A712.
PRIDEiP0A712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76891; AAC76891; b3909.
BAE77400; BAE77400; BAE77400.
GeneIDi948407.
KEGGiecj:JW5560.
eco:b3909.
PATRICi32123331. VBIEscCol129921_4026.

Organism-specific databases

EchoBASEiEB1815.
EcoGeneiEG11869. kdgT.

Phylogenomic databases

eggNOGiENOG4105CAX. Bacteria.
ENOG410XNUJ. LUCA.
HOGENOMiHOG000221851.
InParanoidiP0A712.
KOiK02526.
OMAiESGPFMT.

Enzyme and pathway databases

BioCyciEcoCyc:KDGT-MONOMER.
ECOL316407:JW5560-MONOMER.
MetaCyc:KDGT-MONOMER.

Miscellaneous databases

PROiP0A712.

Family and domain databases

HAMAPiMF_00070. KdgT. 1 hit.
InterProiIPR004684. 2keto-3dGluconate_permease.
IPR018395. 2keto-3dGluconate_permease_sub.
[Graphical view]
PfamiPF03812. KdgT. 1 hit.
[Graphical view]
ProDomiPD024513. 2keto-3dGluconate_permease. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00793. kdgT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDGT_ECOLI
AccessioniPrimary (citable) accession number: P0A712
Secondary accession number(s): P32172, Q2M8K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.