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Protein

Protein HypA

Gene

hypA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not required for the formation of hydrogenases 1 and 2. Plays probably a regulatory role.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2 – 21NickelSequence analysis
Metal bindingi73 – 731NickelSequence analysis
Metal bindingi76 – 761NickelSequence analysis
Metal bindingi90 – 901NickelSequence analysis
Metal bindingi93 – 931NickelSequence analysis

GO - Molecular functioni

  • nickel cation binding Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • cellular protein modification process Source: UniProtKB-HAMAP
  • protein maturation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciEcoCyc:EG10483-MONOMER.
ECOL316407:JW2696-MONOMER.
MetaCyc:EG10483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HypA
Gene namesi
Name:hypA
Ordered Locus Names:b2726, JW2696
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10483. hypA.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of cytoplasmic side of plasma membrane Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Protein HypAPRO_0000129057Add
BLAST

Proteomic databases

PaxDbiP0A700.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hycEP1643114EBI-6290024,EBI-552702

Protein-protein interaction databases

BioGridi4261428. 8 interactions.
DIPiDIP-48022N.
IntActiP0A700. 9 interactions.
STRINGi511145.b2726.

Structurei

3D structure databases

ProteinModelPortaliP0A700.
SMRiP0A700. Positions 2-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HypA/HybF family.Curated

Phylogenomic databases

eggNOGiENOG410816D. Bacteria.
COG0375. LUCA.
HOGENOMiHOG000291317.
InParanoidiP0A700.
KOiK04651.
OMAiEEQQAEC.
PhylomeDBiP0A700.

Family and domain databases

HAMAPiMF_00213. HypA. 1 hit.
InterProiIPR000688. Hydgase_Ni_incorp_HypA/HybF.
IPR020538. Hydgase_Ni_incorp_HypA/HybF_CS.
[Graphical view]
PfamiPF01155. HypA. 1 hit.
[Graphical view]
PIRSFiPIRSF004761. Hydrgn_mat_HypA. 1 hit.
TIGRFAMsiTIGR00100. hypA. 1 hit.
PROSITEiPS01249. HYPA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEITLCQRA LELIEQQAAK HGAKRVTGVW LKIGAFSCVE TSSLAFCFDL
60 70 80 90 100
VCRGSVAEGC KLHLEEQEAE CWCETCQQYV TLLTQRVRRC PQCHGDMLQI
110
VADDGLQIRR IEIDQE
Length:116
Mass (Da):13,168
Last modified:June 7, 2005 - v1
Checksum:i57458941783073D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38412.1.
U29579 Genomic DNA. Translation: AAA69236.1.
U00096 Genomic DNA. Translation: AAC75768.1.
AP009048 Genomic DNA. Translation: BAE76803.1.
PIRiS15197.
RefSeqiNP_417206.1. NC_000913.3.
WP_001299100.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75768; AAC75768; b2726.
BAE76803; BAE76803; BAE76803.
GeneIDi947195.
KEGGiecj:JW2696.
eco:b2726.
PATRICi32120852. VBIEscCol129921_2818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38412.1.
U29579 Genomic DNA. Translation: AAA69236.1.
U00096 Genomic DNA. Translation: AAC75768.1.
AP009048 Genomic DNA. Translation: BAE76803.1.
PIRiS15197.
RefSeqiNP_417206.1. NC_000913.3.
WP_001299100.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A700.
SMRiP0A700. Positions 2-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261428. 8 interactions.
DIPiDIP-48022N.
IntActiP0A700. 9 interactions.
STRINGi511145.b2726.

Proteomic databases

PaxDbiP0A700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75768; AAC75768; b2726.
BAE76803; BAE76803; BAE76803.
GeneIDi947195.
KEGGiecj:JW2696.
eco:b2726.
PATRICi32120852. VBIEscCol129921_2818.

Organism-specific databases

EchoBASEiEB0478.
EcoGeneiEG10483. hypA.

Phylogenomic databases

eggNOGiENOG410816D. Bacteria.
COG0375. LUCA.
HOGENOMiHOG000291317.
InParanoidiP0A700.
KOiK04651.
OMAiEEQQAEC.
PhylomeDBiP0A700.

Enzyme and pathway databases

BioCyciEcoCyc:EG10483-MONOMER.
ECOL316407:JW2696-MONOMER.
MetaCyc:EG10483-MONOMER.

Miscellaneous databases

PROiP0A700.

Family and domain databases

HAMAPiMF_00213. HypA. 1 hit.
InterProiIPR000688. Hydgase_Ni_incorp_HypA/HybF.
IPR020538. Hydgase_Ni_incorp_HypA/HybF_CS.
[Graphical view]
PfamiPF01155. HypA. 1 hit.
[Graphical view]
PIRSFiPIRSF004761. Hydrgn_mat_HypA. 1 hit.
TIGRFAMsiTIGR00100. hypA. 1 hit.
PROSITEiPS01249. HYPA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYPA_ECOLI
AccessioniPrimary (citable) accession number: P0A700
Secondary accession number(s): P24189, Q2MAA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.