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Protein

Protein HypA

Gene

hypA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not required for the formation of hydrogenases 1 and 2. Plays probably a regulatory role.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2 – 21NickelSequence analysis
Metal bindingi73 – 731NickelSequence analysis
Metal bindingi76 – 761NickelSequence analysis
Metal bindingi90 – 901NickelSequence analysis
Metal bindingi93 – 931NickelSequence analysis

GO - Molecular functioni

  • nickel cation binding Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • cellular protein modification process Source: UniProtKB-HAMAP
  • protein maturation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciEcoCyc:EG10483-MONOMER.
ECOL316407:JW2696-MONOMER.
MetaCyc:EG10483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HypA
Gene namesi
Name:hypA
Ordered Locus Names:b2726, JW2696
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10483. hypA.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of cytoplasmic side of plasma membrane Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Protein HypAPRO_0000129057Add
BLAST

Proteomic databases

PaxDbiP0A700.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hycEP1643114EBI-6290024,EBI-552702

Protein-protein interaction databases

BioGridi4261428. 8 interactions.
DIPiDIP-48022N.
IntActiP0A700. 9 interactions.
STRINGi511145.b2726.

Structurei

3D structure databases

ProteinModelPortaliP0A700.
SMRiP0A700. Positions 2-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HypA/HybF family.Curated

Phylogenomic databases

eggNOGiENOG410816D. Bacteria.
COG0375. LUCA.
HOGENOMiHOG000291317.
InParanoidiP0A700.
KOiK04651.
OMAiRRCPQCQ.
OrthoDBiEOG6QVRK2.
PhylomeDBiP0A700.

Family and domain databases

HAMAPiMF_00213. HypA.
InterProiIPR000688. Hydgase_Ni_incorp_HypA/HybF.
IPR020538. Hydgase_Ni_incorp_HypA/HybF_CS.
[Graphical view]
PfamiPF01155. HypA. 1 hit.
[Graphical view]
PIRSFiPIRSF004761. Hydrgn_mat_HypA. 1 hit.
TIGRFAMsiTIGR00100. hypA. 1 hit.
PROSITEiPS01249. HYPA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEITLCQRA LELIEQQAAK HGAKRVTGVW LKIGAFSCVE TSSLAFCFDL
60 70 80 90 100
VCRGSVAEGC KLHLEEQEAE CWCETCQQYV TLLTQRVRRC PQCHGDMLQI
110
VADDGLQIRR IEIDQE
Length:116
Mass (Da):13,168
Last modified:June 7, 2005 - v1
Checksum:i57458941783073D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38412.1.
U29579 Genomic DNA. Translation: AAA69236.1.
U00096 Genomic DNA. Translation: AAC75768.1.
AP009048 Genomic DNA. Translation: BAE76803.1.
PIRiS15197.
RefSeqiNP_417206.1. NC_000913.3.
WP_001299100.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75768; AAC75768; b2726.
BAE76803; BAE76803; BAE76803.
GeneIDi947195.
KEGGiecj:JW2696.
eco:b2726.
PATRICi32120852. VBIEscCol129921_2818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38412.1.
U29579 Genomic DNA. Translation: AAA69236.1.
U00096 Genomic DNA. Translation: AAC75768.1.
AP009048 Genomic DNA. Translation: BAE76803.1.
PIRiS15197.
RefSeqiNP_417206.1. NC_000913.3.
WP_001299100.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A700.
SMRiP0A700. Positions 2-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261428. 8 interactions.
DIPiDIP-48022N.
IntActiP0A700. 9 interactions.
STRINGi511145.b2726.

Proteomic databases

PaxDbiP0A700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75768; AAC75768; b2726.
BAE76803; BAE76803; BAE76803.
GeneIDi947195.
KEGGiecj:JW2696.
eco:b2726.
PATRICi32120852. VBIEscCol129921_2818.

Organism-specific databases

EchoBASEiEB0478.
EcoGeneiEG10483. hypA.

Phylogenomic databases

eggNOGiENOG410816D. Bacteria.
COG0375. LUCA.
HOGENOMiHOG000291317.
InParanoidiP0A700.
KOiK04651.
OMAiRRCPQCQ.
OrthoDBiEOG6QVRK2.
PhylomeDBiP0A700.

Enzyme and pathway databases

BioCyciEcoCyc:EG10483-MONOMER.
ECOL316407:JW2696-MONOMER.
MetaCyc:EG10483-MONOMER.

Miscellaneous databases

PROiP0A700.

Family and domain databases

HAMAPiMF_00213. HypA.
InterProiIPR000688. Hydgase_Ni_incorp_HypA/HybF.
IPR020538. Hydgase_Ni_incorp_HypA/HybF_CS.
[Graphical view]
PfamiPF01155. HypA. 1 hit.
[Graphical view]
PIRSFiPIRSF004761. Hydrgn_mat_HypA. 1 hit.
TIGRFAMsiTIGR00100. hypA. 1 hit.
PROSITEiPS01249. HYPA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of an operon (hyp) necessary for the activity of the three hydrogenase isoenzymes in Escherichia coli."
    Lutz S., Jacobi A., Schlensog V., Boehm R., Sawers G., Boeck A.
    Mol. Microbiol. 5:123-135(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Escherichia coli proteome analysis using the gene-protein database."
    VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
    Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY 2D-GEL.

Entry informationi

Entry nameiHYPA_ECOLI
AccessioniPrimary (citable) accession number: P0A700
Secondary accession number(s): P24189, Q2MAA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: January 20, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.