Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chaperone protein HscA

Gene

hscA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3355-MONOMER.
ECOO157:HSCA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HscA
Alternative name(s):
Hsc66
Gene namesi
Name:hscA
Ordered Locus Names:Z3793, ECs3392
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Chaperone protein HscAPRO_0000078626Add
BLAST

Proteomic databases

PRIDEiP0A6Z2.

Interactioni

Protein-protein interaction databases

MINTiMINT-236572.
STRINGi155864.Z3793.

Structurei

3D structure databases

ProteinModelPortaliP0A6Z2.
SMRiP0A6Z2. Positions 23-615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105C9I. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04044.
OMAiLRGIPAM.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR01991. HscA. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A6Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLQISEPG LSAAPHQRRL AAGIDLGTTN SLVATVRSGQ AETLADHEGR
60 70 80 90 100
HLLPSVVHYQ QQGHSVGYDA RTNAALDTAN TISSVKRLMG RSLADIQQRY
110 120 130 140 150
PHLPYQFQAS ENGLPMIETA AGLLNPVRVS ADILKALAAR ATEALAGELD
160 170 180 190 200
GVVITVPAYF DDAQRQGTKD AARLAGLHVL RLLNEPTAAA IAYGLDSGQE
210 220 230 240 250
GVIAVYDLGG GTFDISILRL SRGVFEVLAT GGDSALGGDD FDHLLADYIR
260 270 280 290 300
EQAGIPDRSD NRVQRELLDA AIAAKIALSD ADSVTVNVAG WQGEISREQF
310 320 330 340 350
NELIAPLVKR TLLACRRALK DAGVEADEVL EVVMVGGSTR VPLVRERVGE
360 370 380 390 400
FFGRPPLTSI DPDKVVAIGA AIQADILVGN KPDSEMLLLD VIPLSLGLET
410 420 430 440 450
MGGLVEKVIP RNTTIPVARA QDFTTFKDGQ TAMSIHVMQG ERELVQDCRS
460 470 480 490 500
LARFALRGIP ALPAGGAHIR VTFQVDADGL LSVTAMEKST GVEASIQVKP
510 520 530 540 550
SYGLTDSEIA SMIKDSMSYA EQDVKARMLA EQKVEAARVL ESLHGALAAD
560 570 580 590 600
AALLSAAERQ VIDDAAAHLS EVAQGDDVDA IEQAIKNVDK QTQDFAARRM
610
DQSVRRALKG HSVDEV
Length:616
Mass (Da):65,652
Last modified:June 7, 2005 - v1
Checksum:i9C80E6EF1BFDAB48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57640.1.
BA000007 Genomic DNA. Translation: BAB36815.1.
PIRiH91052.
RefSeqiNP_311419.1. NC_002695.1.
WP_001196613.1. NZ_LPWC01000059.1.

Genome annotation databases

EnsemblBacteriaiAAG57640; AAG57640; Z3793.
BAB36815; BAB36815; BAB36815.
GeneIDi915196.
KEGGiece:Z3793.
ecs:ECs3392.
PATRICi18356214. VBIEscCol44059_3302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57640.1.
BA000007 Genomic DNA. Translation: BAB36815.1.
PIRiH91052.
RefSeqiNP_311419.1. NC_002695.1.
WP_001196613.1. NZ_LPWC01000059.1.

3D structure databases

ProteinModelPortaliP0A6Z2.
SMRiP0A6Z2. Positions 23-615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-236572.
STRINGi155864.Z3793.

Proteomic databases

PRIDEiP0A6Z2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57640; AAG57640; Z3793.
BAB36815; BAB36815; BAB36815.
GeneIDi915196.
KEGGiece:Z3793.
ecs:ECs3392.
PATRICi18356214. VBIEscCol44059_3302.

Phylogenomic databases

eggNOGiENOG4105C9I. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04044.
OMAiLRGIPAM.
OrthoDBiEOG6JMMSV.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3355-MONOMER.
ECOO157:HSCA-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR01991. HscA. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiHSCA_ECO57
AccessioniPrimary (citable) accession number: P0A6Z2
Secondary accession number(s): P36541, P76990, P77497
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.