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P0A6Z0 (DNAK_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene names
Name:dnaK
Ordered Locus Names:Z0014, ECs0014
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a chaperone By similarity. HAMAP-Rule MF_00332

Induction

By stress conditions e.g. heat shock By similarity. HAMAP-Rule MF_00332

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 638637Chaperone protein DnaK HAMAP-Rule MF_00332
PRO_0000078460

Amino acid modifications

Modified residue1091N6-acetyllysine By similarity
Modified residue1991Phosphothreonine; by autocatalysis By similarity
Modified residue2451N6-acetyllysine By similarity
Modified residue3041N6-acetyllysine By similarity
Modified residue4211N6-acetyllysine By similarity
Modified residue5561N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A6Z0 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 5A8589B21D7CD9C1

FASTA63869,115
        10         20         30         40         50         60 
MGKIIGIDLG TTNSCVAIMD GTTPRVLENA EGDRTTPSII AYTQDGETLV GQPAKRQAVT 

        70         80         90        100        110        120 
NPQNTLFAIK RLIGRRFQDE EVQRDVSIMP FKIIAADNGD AWVEVKGQKM APPQISAEVL 

       130        140        150        160        170        180 
KKMKKTAEDY LGEPVTEAVI TVPAYFNDAQ RQATKDAGRI AGLEVKRIIN EPTAAALAYG 

       190        200        210        220        230        240 
LDKGTGNRTI AVYDLGGGTF DISIIEIDEV DGEKTFEVLA TNGDTHLGGE DFDSRLINYL 

       250        260        270        280        290        300 
VEEFKKDQGI DLRNDPLAMQ RLKEAAEKAK IELSSAQQTD VNLPYITADA TGPKHMNIKV 

       310        320        330        340        350        360 
TRAKLESLVE DLVNRSIEPL KVALQDAGLS VSDIDDVILV GGQTRMPMVQ KKVAEFFGKE 

       370        380        390        400        410        420 
PRKDVNPDEA VAIGAAVQGG VLTGDVKDVL LLDVTPLSLG IETMGGVMTT LIAKNTTIPT 

       430        440        450        460        470        480 
KHSQVFSTAE DNQSAVTIHV LQGERKRAAD NKSLGQFNLD GINPAPRGMP QIEVTFDIDA 

       490        500        510        520        530        540 
DGILHVSAKD KNSGKEQKIT IKASSGLNED EIQKMVRDAE ANAEADRKFE ELVQTRNQGD 

       550        560        570        580        590        600 
HLLHSTRKQV EEAGDKLPAD DKTAIESALT ALETALKGED KAAIEAKMQE LAQVSQKLME 

       610        620        630 
IAQQQHAQQQ TAGADASANN AKDDDVVDAE FEEVKDKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005174 Genomic DNA. Translation: AAG54314.1.
BA000007 Genomic DNA. Translation: BAB33437.1.
PIRF85481.
F90630.
RefSeqNP_285706.1. NC_002655.2.
NP_308041.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0A6Z0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1216219.
STRING155864.Z0014.

Proteomic databases

PRIDEP0A6Z0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG54314; AAG54314; Z0014.
BAB33437; BAB33437; BAB33437.
GeneID913406.
956673.
KEGGece:Z0014.
ecs:ECs0014.
PATRIC18348964. VBIEscCol44059_0012.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228136.
KOK04043.
OMAQRDVAIM.
OrthoDBEOG6JMMSV.

Enzyme and pathway databases

BioCycECOL386585:GJFA-13-MONOMER.
ECOO157:DNAK-MONOMER.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPMF_00332. DnaK.
InterProIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsTIGR02350. prok_dnaK. 1 hit.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAK_ECO57
AccessionPrimary (citable) accession number: P0A6Z0
Secondary accession number(s): P04475
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families