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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.1 Publication

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Cofactori

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandMagnesium, Manganese

Enzyme and pathway databases

BioCyciEcoCyc:PHOSNACMURPENTATRANS-MONOMER
MetaCyc:PHOSNACMURPENTATRANS-MONOMER
UniPathwayiUPA00219

Protein family/group databases

TCDBi9.B.146.1.6 the putative undecaprenyl-phosphate n-acetylglucosaminyl transferase (murg) family

Chemistry databases

SwissLipidsiSLP:000001813

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Synonyms:murX
Ordered Locus Names:b0087, JW0085
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10604 mraY

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18Periplasmic1 PublicationAdd BLAST18
Transmembranei19 – 45HelicalAdd BLAST27
Topological domaini46 – 76Cytoplasmic1 PublicationAdd BLAST31
Transmembranei77 – 90HelicalAdd BLAST14
Topological domaini91 – 96Periplasmic1 Publication6
Transmembranei97 – 113HelicalAdd BLAST17
Topological domaini114 – 133Cytoplasmic1 PublicationAdd BLAST20
Transmembranei134 – 156HelicalAdd BLAST23
Topological domaini157 – 173Periplasmic1 PublicationAdd BLAST17
Transmembranei174 – 188HelicalAdd BLAST15
Topological domaini189 – 199Cytoplasmic1 PublicationAdd BLAST11
Transmembranei200 – 220HelicalAdd BLAST21
Topological domaini221 – 238Periplasmic1 PublicationAdd BLAST18
Transmembranei239 – 251HelicalAdd BLAST13
Topological domaini252 – 270Cytoplasmic1 PublicationAdd BLAST19
Transmembranei271 – 284HelicalAdd BLAST14
Topological domaini285 – 287Periplasmic1 Publication3
Transmembranei288 – 299HelicalAdd BLAST12
Topological domaini300 – 341Cytoplasmic1 PublicationAdd BLAST42
Transmembranei342 – 357HelicalAdd BLAST16
Topological domaini358 – 360Periplasmic1 Publication3

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3957

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088201 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Proteomic databases

PaxDbiP0A6W3
PRIDEiP0A6W3

Interactioni

Protein-protein interaction databases

BioGridi4261478, 375 interactors
STRINGi316385.ECDH10B_0069

Chemistry databases

BindingDBiP0A6W3

Structurei

3D structure databases

ProteinModelPortaliP0A6W3
SMRiP0A6W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
InParanoidiP0A6W3
KOiK01000
OMAiLMSPLHH
PhylomeDBiP0A6W3

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVWLAEHLV KYYSGFNVFS YLTFRAIVSL LTALFISLWM GPRMIAHLQK
60 70 80 90 100
LSFGQVVRND GPESHFSKRG TPTMGGIMIL TAIVISVLLW AYPSNPYVWC
110 120 130 140 150
VLVVLVGYGV IGFVDDYRKV VRKDTKGLIA RWKYFWMSVI ALGVAFALYL
160 170 180 190 200
AGKDTPATQL VVPFFKDVMP QLGLFYILLA YFVIVGTGNA VNLTDGLDGL
210 220 230 240 250
AIMPTVFVAG GFALVAWATG NMNFASYLHI PYLRHAGELV IVCTAIVGAG
260 270 280 290 300
LGFLWFNTYP AQVFMGDVGS LALGGALGII AVLLRQEFLL VIMGGVFVVE
310 320 330 340 350
TLSVILQVGS FKLRGQRIFR MAPIHHHYEL KGWPEPRVIV RFWIISLMLV
360
LIGLATLKVR
Length:360
Mass (Da):39,875
Last modified:March 15, 2005 - v1
Checksum:iF3550AFA3CD636AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51584 Genomic DNA Translation: CAA35932.1
X55034 Genomic DNA Translation: CAA38864.1
U00096 Genomic DNA Translation: AAC73198.1
AP009048 Genomic DNA Translation: BAB96655.1
PIRiS08395
RefSeqiNP_414629.1, NC_000913.3
WP_000964131.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73198; AAC73198; b0087
BAB96655; BAB96655; BAB96655
GeneIDi944814
KEGGiecj:JW0085
eco:b0087
PATRICifig|1411691.4.peg.2193

Entry informationi

Entry nameiMRAY_ECOLI
AccessioniPrimary (citable) accession number: P0A6W3
Secondary accession number(s): P15876
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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