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Protein

Glucokinase

Gene

glk

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOO157:GLK-MONOMER.
BRENDAi2.7.1.2. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glk
Ordered Locus Names:Z3654, ECs3268
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151251 – 321GlucokinaseAdd BLAST321

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3654.

Structurei

Secondary structure

1321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi14 – 21Combined sources8
Turni22 – 24Combined sources3
Beta strandi27 – 34Combined sources8
Helixi35 – 37Combined sources3
Helixi41 – 51Combined sources11
Beta strandi58 – 65Combined sources8
Beta strandi69 – 72Combined sources4
Beta strandi75 – 77Combined sources3
Helixi83 – 90Combined sources8
Beta strandi93 – 99Combined sources7
Helixi100 – 107Combined sources8
Helixi108 – 110Combined sources3
Helixi113 – 115Combined sources3
Beta strandi116 – 118Combined sources3
Beta strandi130 – 147Combined sources18
Beta strandi150 – 155Combined sources6
Helixi158 – 160Combined sources3
Helixi168 – 180Combined sources13
Beta strandi181 – 183Combined sources3
Helixi186 – 188Combined sources3
Helixi192 – 205Combined sources14
Helixi215 – 224Combined sources10
Helixi228 – 252Combined sources25
Beta strandi257 – 261Combined sources5
Beta strandi263 – 265Combined sources3
Helixi266 – 268Combined sources3
Helixi269 – 274Combined sources6
Helixi277 – 282Combined sources6
Helixi285 – 287Combined sources3
Helixi288 – 291Combined sources4
Beta strandi296 – 299Combined sources4
Helixi304 – 316Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q18X-ray2.36A/B2-321[»]
1SZ2X-ray2.20A/B2-321[»]
ProteinModelPortaliP0A6V9.
SMRiP0A6V9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6V9.

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial glucokinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CHC. Bacteria.
COG0837. LUCA.
HOGENOMiHOG000274469.
KOiK00845.
OMAiGHADFAP.

Family and domain databases

HAMAPiMF_00524. Glucokinase. 1 hit.
InterProiIPR003836. Glucokinase.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00749. glk. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A6V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE
60 70 80 90 100
EHKVEVKDGC IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND
110 120 130 140 150
FTAVSMAIPM LKKEHLIQFG GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR
160 170 180 190 200
WVSLPGEGGH VDFAPNSEEE AIILEILRAE IGHVSAERVL SGPGLVNLYR
210 220 230 240 250
AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI MGRFGGNLAL
260 270 280 290 300
NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV
310 320
HDNPGLLGSG AHLRQTLGHI L
Length:321
Mass (Da):34,723
Last modified:March 29, 2005 - v1
Checksum:i2D6CD956641A3823
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57514.1.
BA000007 Genomic DNA. Translation: BAB36691.1.
PIRiD91037.
F85881.
RefSeqiNP_311295.1. NC_002695.1.
WP_000170346.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG57514; AAG57514; Z3654.
BAB36691; BAB36691; BAB36691.
GeneIDi915629.
KEGGiece:Z3654.
ecs:ECs3268.
PATRICi18355936. VBIEscCol44059_3168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57514.1.
BA000007 Genomic DNA. Translation: BAB36691.1.
PIRiD91037.
F85881.
RefSeqiNP_311295.1. NC_002695.1.
WP_000170346.1. NZ_LPWC02000002.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q18X-ray2.36A/B2-321[»]
1SZ2X-ray2.20A/B2-321[»]
ProteinModelPortaliP0A6V9.
SMRiP0A6V9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z3654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57514; AAG57514; Z3654.
BAB36691; BAB36691; BAB36691.
GeneIDi915629.
KEGGiece:Z3654.
ecs:ECs3268.
PATRICi18355936. VBIEscCol44059_3168.

Phylogenomic databases

eggNOGiENOG4105CHC. Bacteria.
COG0837. LUCA.
HOGENOMiHOG000274469.
KOiK00845.
OMAiGHADFAP.

Enzyme and pathway databases

BioCyciECOO157:GLK-MONOMER.
BRENDAi2.7.1.2. 2026.

Miscellaneous databases

EvolutionaryTraceiP0A6V9.

Family and domain databases

HAMAPiMF_00524. Glucokinase. 1 hit.
InterProiIPR003836. Glucokinase.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00749. glk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLK_ECO57
AccessioniPrimary (citable) accession number: P0A6V9
Secondary accession number(s): P46880, P78276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.