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Protein

Glucokinase

Gene

glk

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.2 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glk
Ordered Locus Names:Z3654, ECs3268
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151251 – 321GlucokinaseAdd BLAST321

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3654

Structurei

Secondary structure

1321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi14 – 21Combined sources8
Turni22 – 24Combined sources3
Beta strandi27 – 34Combined sources8
Helixi35 – 37Combined sources3
Helixi41 – 51Combined sources11
Beta strandi58 – 65Combined sources8
Beta strandi69 – 72Combined sources4
Beta strandi75 – 77Combined sources3
Helixi83 – 90Combined sources8
Beta strandi93 – 99Combined sources7
Helixi100 – 107Combined sources8
Helixi108 – 110Combined sources3
Helixi113 – 115Combined sources3
Beta strandi116 – 118Combined sources3
Beta strandi130 – 147Combined sources18
Beta strandi150 – 155Combined sources6
Helixi158 – 160Combined sources3
Helixi168 – 180Combined sources13
Beta strandi181 – 183Combined sources3
Helixi186 – 188Combined sources3
Helixi192 – 205Combined sources14
Helixi215 – 224Combined sources10
Helixi228 – 252Combined sources25
Beta strandi257 – 261Combined sources5
Beta strandi263 – 265Combined sources3
Helixi266 – 268Combined sources3
Helixi269 – 274Combined sources6
Helixi277 – 282Combined sources6
Helixi285 – 287Combined sources3
Helixi288 – 291Combined sources4
Beta strandi296 – 299Combined sources4
Helixi304 – 316Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q18X-ray2.36A/B2-321[»]
1SZ2X-ray2.20A/B2-321[»]
ProteinModelPortaliP0A6V9
SMRiP0A6V9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6V9

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial glucokinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CHC Bacteria
COG0837 LUCA
HOGENOMiHOG000274469
KOiK00845
OMAiFCVLMGR

Family and domain databases

HAMAPiMF_00524 Glucokinase, 1 hit
InterProiView protein in InterPro
IPR003836 Glucokinase
PfamiView protein in Pfam
PF02685 Glucokinase, 1 hit
TIGRFAMsiTIGR00749 glk, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE
60 70 80 90 100
EHKVEVKDGC IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND
110 120 130 140 150
FTAVSMAIPM LKKEHLIQFG GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR
160 170 180 190 200
WVSLPGEGGH VDFAPNSEEE AIILEILRAE IGHVSAERVL SGPGLVNLYR
210 220 230 240 250
AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI MGRFGGNLAL
260 270 280 290 300
NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV
310 320
HDNPGLLGSG AHLRQTLGHI L
Length:321
Mass (Da):34,723
Last modified:March 29, 2005 - v1
Checksum:i2D6CD956641A3823
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57514.1
BA000007 Genomic DNA Translation: BAB36691.1
PIRiD91037
F85881
RefSeqiNP_311295.1, NC_002695.1
WP_000170346.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG57514; AAG57514; Z3654
BAB36691; BAB36691; BAB36691
GeneIDi915629
KEGGiece:Z3654
ecs:ECs3268
PATRICifig|386585.9.peg.3412

Similar proteinsi

Entry informationi

Entry nameiGLK_ECO57
AccessioniPrimary (citable) accession number: P0A6V9
Secondary accession number(s): P46880, P78276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health