Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Enzyme regulationi

Allosterically activated by fructose-1,6-bisphosphate (F16BP) and inhibited by AMP.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39Fructose-1,6-bisphosphateUniRule annotation1
Binding sitei40AMPUniRule annotation1
Binding sitei46AMPUniRule annotation1
Binding sitei52AMPUniRule annotation1
Sitei74Could play a key role in the communication between the regulatory and the substrate sitesUniRule annotation1
Sitei113Could play a key role in the communication between the regulatory and the substrate sitesUniRule annotation1
Binding sitei114Alpha-D-glucose 1-phosphateUniRule annotation1
Binding sitei130AMPUniRule annotation1
Binding sitei179Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei212Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1
Binding sitei370AMPUniRule annotation1
Binding sitei386AMPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Nucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:Z4792, ECs4275
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001952962 – 431Glucose-1-phosphate adenylyltransferaseAdd BLAST430

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z4792

Structurei

3D structure databases

ProteinModelPortaliP0A6V3
SMRiP0A6V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 195Alpha-D-glucose 1-phosphate bindingUniRule annotation2
Regioni419 – 423Fructose-1,6-bisphosphate bindingUniRule annotation5
Regioni429 – 431Fructose-1,6-bisphosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4 Bacteria
COG0448 LUCA
HOGENOMiHOG000278607
KOiK00975
OMAiHCVLGVR

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00624 GlgC, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR023049 GlgC_bac
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00808 ADP_GLC_PYROPHOSPH_1, 1 hit
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A6V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLEKNDHL MLARQLPLKS VALILAGGRG TRLKDLTNKR AKPAVHFGGK
60 70 80 90 100
FRIIDFALSN CINSGIRRMG VITQYQSHTL VQHIQRGWSF FNEEMNEFVD
110 120 130 140 150
LLPAQQRMKG ENWYRGTADA VTQNLDIIRR YKAEYVVILA GDHIYKQDYS
160 170 180 190 200
RMLIDHVEKG ARCTVACMPV PIEEASAFGV MAVDENDKII EFVEKPANPP
210 220 230 240 250
SMPNDPSKSL ASMGIYVFDA DYLYELLEED DRDENSSHDF GKDLIPKITE
260 270 280 290 300
AGLAYAHPFP LSCVQSDPDA EPYWRDVGTL EAYWKANLDL ASVVPELDMY
310 320 330 340 350
DRNWPIRTYN ESLPPAKFVQ DRSGSHGMTL NSLVSGGCVI SGSVVVQSVL
360 370 380 390 400
FSRVRVNSFC NIDSAVLLPE VWVGRSCRLR RCVIDRACVI PEGMVIGENA
410 420 430
EEDARRFYRS EEGIVLVTRE MLRKLGHKQE R
Length:431
Mass (Da):48,698
Last modified:January 23, 2007 - v2
Checksum:i3C0A4C4F5B13D9D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58536.1
BA000007 Genomic DNA Translation: BAB37698.1
PIRiC91163
D86009
RefSeqiNP_312302.1, NC_002695.1
WP_000253975.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58536; AAG58536; Z4792
BAB37698; BAB37698; BAB37698
GeneIDi915871
KEGGiece:Z4792
ecs:ECs4275
PATRICifig|386585.9.peg.4466

Similar proteinsi

Entry informationi

Entry nameiGLGC_ECO57
AccessioniPrimary (citable) accession number: P0A6V3
Secondary accession number(s): P00584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health