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Protein

Glycogen synthase

Gene

glgA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Synthesizes alpha-1,4-glucan chains using ADP-glucose.

Catalytic activityi

ADP-glucose + (1,4-alpha-D-glucosyl)(n) = ADP + (1,4-alpha-D-glucosyl)(n+1).

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15ADP-glucose1

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • glycogen biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:GLYCOGENSYN-MONOMER
MetaCyc:GLYCOGENSYN-MONOMER
BRENDAi2.4.1.21 2026
UniPathwayiUPA00164

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen synthase (EC:2.4.1.21)
Alternative name(s):
Starch [bacterial glycogen] synthase
Gene namesi
Name:glgA
Ordered Locus Names:b3429, JW3392
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10377 glgA

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001886111 – 477Glycogen synthaseAdd BLAST477

Proteomic databases

EPDiP0A6U8
PaxDbiP0A6U8
PRIDEiP0A6U8

Interactioni

Protein-protein interaction databases

BioGridi4262501326 interactors.
IntActiP0A6U8 1 interactor.
STRINGi316385.ECDH10B_3603

Structurei

Secondary structure

1477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Turni11 – 13Combined sources3
Helixi18 – 32Combined sources15
Beta strandi36 – 42Combined sources7
Helixi45 – 50Combined sources6
Beta strandi55 – 60Combined sources6
Beta strandi67 – 74Combined sources8
Beta strandi77 – 83Combined sources7
Helixi85 – 88Combined sources4
Beta strandi91 – 93Combined sources3
Beta strandi94 – 96Combined sources3
Helixi106 – 120Combined sources15
Turni121 – 123Combined sources3
Beta strandi131 – 136Combined sources6
Helixi138 – 140Combined sources3
Helixi143 – 149Combined sources7
Beta strandi153 – 161Combined sources9
Beta strandi168 – 170Combined sources3
Helixi171 – 175Combined sources5
Turni176 – 178Combined sources3
Helixi181 – 183Combined sources3
Turni186 – 189Combined sources4
Beta strandi194 – 196Combined sources3
Helixi197 – 204Combined sources8
Beta strandi206 – 212Combined sources7
Helixi213 – 218Combined sources6
Helixi222 – 225Combined sources4
Helixi229 – 237Combined sources9
Beta strandi241 – 243Combined sources3
Turni250 – 252Combined sources3
Turni255 – 257Combined sources3
Beta strandi261 – 263Combined sources3
Helixi270 – 273Combined sources4
Helixi274 – 284Combined sources11
Beta strandi290 – 292Combined sources3
Beta strandi294 – 302Combined sources9
Helixi303 – 305Combined sources3
Helixi307 – 319Combined sources13
Beta strandi323 – 330Combined sources8
Helixi332 – 344Combined sources13
Turni346 – 348Combined sources3
Beta strandi349 – 354Combined sources6
Helixi357 – 366Combined sources10
Beta strandi368 – 372Combined sources5
Helixi382 – 389Combined sources8
Beta strandi392 – 398Combined sources7
Helixi399 – 404Combined sources6
Helixi410 – 414Combined sources5
Beta strandi420 – 423Combined sources4
Beta strandi425 – 427Combined sources3
Helixi428 – 442Combined sources15
Helixi445 – 457Combined sources13
Helixi462 – 476Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QZSX-ray2.20A1-477[»]
2R4TX-ray2.26A1-477[»]
2R4UX-ray2.37A1-477[»]
3COPX-ray2.30A1-477[»]
3CX4X-ray2.29A1-477[»]
3D1JX-ray3.00A1-477[»]
3GUHX-ray2.79A1-477[»]
ProteinModelPortaliP0A6U8
SMRiP0A6U8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6U8

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXW Bacteria
COG0297 LUCA
HOGENOMiHOG000294941
InParanoidiP0A6U8
KOiK00703
OMAiTWCPWYM
PhylomeDBiP0A6U8

Family and domain databases

HAMAPiMF_00484 Glycogen_synth, 1 hit
InterProiView protein in InterPro
IPR001296 Glyco_trans_1
IPR011835 GS/SS
IPR013534 Starch_synth_cat_dom
PfamiView protein in Pfam
PF08323 Glyco_transf_5, 1 hit
PF00534 Glycos_transf_1, 1 hit
TIGRFAMsiTIGR02095 glgA, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLHVCSEM FPLLKTGGLA DVIGALPAAQ IADGVDARVL LPAFPDIRRG
60 70 80 90 100
VTDAQVVSRR DTFAGHITLL FGHYNGVGIY LIDAPHLYDR PGSPYHDTNL
110 120 130 140 150
FAYTDNVLRF ALLGWVGAEM ASGLDPFWRP DVVHAHDWHA GLAPAYLAAR
160 170 180 190 200
GRPAKSVFTV HNLAYQGMFY AHHMNDIQLP WSFFNIHGLE FNGQISFLKA
210 220 230 240 250
GLYYADHITA VSPTYAREIT EPQFAYGMEG LLQQRHREGR LSGVLNGVDE
260 270 280 290 300
KIWSPETDLL LASRYTRDTL EDKAENKRQL QIAMGLKVDD KVPLFAVVSR
310 320 330 340 350
LTSQKGLDLV LEALPGLLEQ GGQLALLGAG DPVLQEGFLA AAAEYPGQVG
360 370 380 390 400
VQIGYHEAFS HRIMGGADVI LVPSRFEPCG LTQLYGLKYG TLPLVRRTGG
410 420 430 440 450
LADTVSDCSL ENLADGVASG FVFEDSNAWS LLRAIRRAFV LWSRPSLWRF
460 470
VQRQAMAMDF SWQVAAKSYR ELYYRLK
Length:477
Mass (Da):52,822
Last modified:March 29, 2005 - v1
Checksum:i177CF37F8C97CF42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63F → S in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti102 – 103AY → VH in AAA23870 (PubMed:3097003).Curated2
Sequence conflicti245L → P in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti280L → S in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti286L → S in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti309L → S in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti314L → S in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti317 – 318LL → SS in AAA23870 (PubMed:3097003).Curated2
Sequence conflicti387L → S in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti419S → N in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti422V → I in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti434A → T in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti444R → C (PubMed:3097003).Curated1
Sequence conflicti446S → P (PubMed:3097003).Curated1
Sequence conflicti461S → G in AAA23870 (PubMed:3097003).Curated1
Sequence conflicti476L → S in AAA23870 (PubMed:3097003).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00281 Genomic DNA Translation: CAA23545.1
J02616 Genomic DNA Translation: AAA23870.1
U18997 Genomic DNA Translation: AAA58227.1
U00096 Genomic DNA Translation: AAC76454.1
AP009048 Genomic DNA Translation: BAE77863.1
J01616 Genomic DNA Translation: AAA98737.1
PIRiH65138 SYECGL
RefSeqiNP_417887.1, NC_000913.3
WP_001197646.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76454; AAC76454; b3429
BAE77863; BAE77863; BAE77863
GeneIDi947932
KEGGiecj:JW3392
eco:b3429
PATRICifig|1411691.4.peg.3299

Similar proteinsi

Entry informationi

Entry nameiGLGA_ECOLI
AccessioniPrimary (citable) accession number: P0A6U8
Secondary accession number(s): P08323, Q2M793
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome