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Protein

Cell division protein FtsB

Gene

ftsB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.UniRule annotation2 Publications

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

GO - Biological processi

  • cell division Source: EcoliWiki
  • FtsZ-dependent cytokinesis Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:G7424-MONOMER.
ECOL316407:JW2718-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsBUniRule annotation
Gene namesi
Name:ftsBUniRule annotation
Synonyms:ygbQ
Ordered Locus Names:b2748, JW2718
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13111. ftsB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicUniRule annotation
Transmembranei4 – 2118HelicalUniRule annotationAdd
BLAST
Topological domaini22 – 10382PeriplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • cell septum Source: EcoliWiki
  • integral component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants form long filaments, but DNA segregation is not affected.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Cell division protein FtsBPRO_0000214441Add
BLAST

Proteomic databases

PaxDbiP0A6S5.
PRIDEiP0A6S5.

Interactioni

Subunit structurei

Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts also with FtsI and FtsN.UniRule annotation4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ftsLP0AEN418EBI-1113953,EBI-1119082
ftsQP0613610EBI-1113953,EBI-1130157

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4262281. 240 interactions.
DIPiDIP-12117N.
IntActiP0A6S5. 8 interactions.
STRINGi511145.b2748.

Structurei

Secondary structure

1
103
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 5932Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IFFX-ray2.30A/B/C/D28-63[»]
ProteinModelPortaliP0A6S5.
SMRiP0A6S5. Positions 28-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 7141UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 7232Leucine zipper-likeAdd
BLAST

Domaini

The transmembrane segment and the membrane-proximal periplasmic region, which forms a coiled-coil structure, are required for interaction with FtsL and recruitment of downstream division proteins. The C-terminal region is required for interaction with FtsQ, but is not required for recruitment of the downstream division protein FtsI. Contains a leucine zipper-like (LZ) motif, which is required for optimal interaction with FtsL.2 Publications

Sequence similaritiesi

Belongs to the FtsB family.UniRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105XX3. Bacteria.
COG2919. LUCA.
HOGENOMiHOG000262021.
InParanoidiP0A6S5.
KOiK05589.
OMAiDYVRVKD.
OrthoDBiEOG6P5ZC4.
PhylomeDBiP0A6S5.

Family and domain databases

HAMAPiMF_00599. FtsB.
InterProiIPR023081. Cell_div_FtsB.
IPR007060. FtsL/DivIC.
[Graphical view]
PfamiPF04977. DivIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A6S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLTLLLLA ILVWLQYSLW FGKNGIHDYT RVNDDVAAQQ ATNAKLKARN
60 70 80 90 100
DQLFAEIDDL NGGQEALEER ARNELSMTRP GETFYRLVPD ASKRAQSAGQ

NNR
Length:103
Mass (Da):11,622
Last modified:March 29, 2005 - v1
Checksum:i9B50A7EF637809D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA. Translation: AAA69258.1.
U00096 Genomic DNA. Translation: AAC75790.1.
AP009048 Genomic DNA. Translation: BAE76825.1.
PIRiH65055.
RefSeqiNP_417228.1. NC_000913.3.
WP_000517476.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75790; AAC75790; b2748.
BAE76825; BAE76825; BAE76825.
GeneIDi946033.
KEGGiecj:JW2718.
eco:b2748.
PATRICi32120902. VBIEscCol129921_2843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA. Translation: AAA69258.1.
U00096 Genomic DNA. Translation: AAC75790.1.
AP009048 Genomic DNA. Translation: BAE76825.1.
PIRiH65055.
RefSeqiNP_417228.1. NC_000913.3.
WP_000517476.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IFFX-ray2.30A/B/C/D28-63[»]
ProteinModelPortaliP0A6S5.
SMRiP0A6S5. Positions 28-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262281. 240 interactions.
DIPiDIP-12117N.
IntActiP0A6S5. 8 interactions.
STRINGi511145.b2748.

Proteomic databases

PaxDbiP0A6S5.
PRIDEiP0A6S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75790; AAC75790; b2748.
BAE76825; BAE76825; BAE76825.
GeneIDi946033.
KEGGiecj:JW2718.
eco:b2748.
PATRICi32120902. VBIEscCol129921_2843.

Organism-specific databases

EchoBASEiEB2914.
EcoGeneiEG13111. ftsB.

Phylogenomic databases

eggNOGiENOG4105XX3. Bacteria.
COG2919. LUCA.
HOGENOMiHOG000262021.
InParanoidiP0A6S5.
KOiK05589.
OMAiDYVRVKD.
OrthoDBiEOG6P5ZC4.
PhylomeDBiP0A6S5.

Enzyme and pathway databases

BioCyciEcoCyc:G7424-MONOMER.
ECOL316407:JW2718-MONOMER.

Miscellaneous databases

PROiP0A6S5.

Family and domain databases

HAMAPiMF_00599. FtsB.
InterProiIPR023081. Cell_div_FtsB.
IPR007060. FtsL/DivIC.
[Graphical view]
PfamiPF04977. DivIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site."
    Buddelmeijer N., Judson N., Boyd D., Mekalanos J.J., Beckwith J.
    Proc. Natl. Acad. Sci. U.S.A. 99:6316-6321(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FTSL, DISRUPTION PHENOTYPE.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
  4. "A complex of the Escherichia coli cell division proteins FtsL, FtsB and FtsQ forms independently of its localization to the septal region."
    Buddelmeijer N., Beckwith J.
    Mol. Microbiol. 52:1315-1327(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
  5. "Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis."
    Karimova G., Dautin N., Ladant D.
    J. Bacteriol. 187:2233-2243(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FTSL; FTSQ; FTSI AND FTSN.
    Strain: K12.
  6. "Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins."
    Gonzalez M.D., Beckwith J.
    J. Bacteriol. 191:2815-2825(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH FTSL AND FTSQ, DOMAIN.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
  7. "A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex."
    Villanelo F., Ordenes A., Brunet J., Lagos R., Monasterio O.
    BMC Struct. Biol. 11:28-28(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE FTSB/FTSL/FTSQ COMPLEX.
  8. "Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB."
    Robichon C., Karimova G., Beckwith J., Ladant D.
    J. Bacteriol. 193:4988-4992(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, LEUCINE ZIPPER-LIKE MOTIF.

Entry informationi

Entry nameiFTSB_ECOLI
AccessioniPrimary (citable) accession number: P0A6S5
Secondary accession number(s): Q2MA81, Q46894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: April 13, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The C-terminal domain of FtsB is degraded in the absence of either FtsL or FtsQ.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.