Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-binding protein Fis

Gene

fis

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi74 – 9320H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4095-MONOMER.
ECOO157:FIS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein FisUniRule annotation
Gene namesi
Name:fisUniRule annotation
Ordered Locus Names:Z4621, ECs4133
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898DNA-binding protein FisPRO_0000203880Add
BLAST

Proteomic databases

PRIDEiP0A6R5.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

MINTiMINT-1225050.
STRINGi155864.Z4621.

Structurei

3D structure databases

ProteinModelPortaliP0A6R5.
SMRiP0A6R5. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transcriptional regulatory Fis family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VY0. Bacteria.
COG2901. LUCA.
HOGENOMiHOG000256331.
KOiK03557.
OMAiMSDNANL.
OrthoDBiEOG67HJXZ.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00166. DNA_binding_Fis.
InterProiIPR005412. Fis_DNA-bd.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
[Graphical view]
PIRSFiPIRSF002097. DNA-binding_Fis. 1 hit.
PRINTSiPR01591. DNABINDNGFIS.
PR01590. HTHFIS.
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A6R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL
60 70 80 90
YELVLAEVEQ PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN
Length:98
Mass (Da):11,240
Last modified:May 10, 2005 - v1
Checksum:i2E339BFCFCDB163C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58389.1.
BA000007 Genomic DNA. Translation: BAB37556.1.
PIRiA85991.
E91145.
RefSeqiNP_312160.1. NC_002695.1.
WP_000462905.1. NZ_LPWC01000033.1.

Genome annotation databases

EnsemblBacteriaiAAG58389; AAG58389; Z4621.
BAB37556; BAB37556; BAB37556.
GeneIDi8911232.
916019.
KEGGiece:Z4621.
ecs:ECs4133.
PATRICi18357798. VBIEscCol44059_4073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58389.1.
BA000007 Genomic DNA. Translation: BAB37556.1.
PIRiA85991.
E91145.
RefSeqiNP_312160.1. NC_002695.1.
WP_000462905.1. NZ_LPWC01000033.1.

3D structure databases

ProteinModelPortaliP0A6R5.
SMRiP0A6R5. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1225050.
STRINGi155864.Z4621.

Proteomic databases

PRIDEiP0A6R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG58389; AAG58389; Z4621.
BAB37556; BAB37556; BAB37556.
GeneIDi8911232.
916019.
KEGGiece:Z4621.
ecs:ECs4133.
PATRICi18357798. VBIEscCol44059_4073.

Phylogenomic databases

eggNOGiENOG4105VY0. Bacteria.
COG2901. LUCA.
HOGENOMiHOG000256331.
KOiK03557.
OMAiMSDNANL.
OrthoDBiEOG67HJXZ.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4095-MONOMER.
ECOO157:FIS-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00166. DNA_binding_Fis.
InterProiIPR005412. Fis_DNA-bd.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
[Graphical view]
PIRSFiPIRSF002097. DNA-binding_Fis. 1 hit.
PRINTSiPR01591. DNABINDNGFIS.
PR01590. HTHFIS.
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiFIS_ECO57
AccessioniPrimary (citable) accession number: P0A6R5
Secondary accession number(s): P11028, P37404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.