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Protein

DNA-binding protein Fis

Gene

fis

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi74 – 93H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein FisUniRule annotation
Gene namesi
Name:fisUniRule annotation
Ordered Locus Names:Z4621, ECs4133
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002038801 – 98DNA-binding protein FisAdd BLAST98

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z4621

Structurei

3D structure databases

ProteinModelPortaliP0A6R5
SMRiP0A6R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transcriptional regulatory Fis family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VY0 Bacteria
COG2901 LUCA
HOGENOMiHOG000256331
KOiK03557
OMAiMVLCEVE

Family and domain databases

HAMAPiMF_00166 DNA_binding_Fis, 1 hit
InterProiView protein in InterPro
IPR005412 Fis_DNA-bd
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
PfamiView protein in Pfam
PF02954 HTH_8, 1 hit
PIRSFiPIRSF002097 DNA-binding_Fis, 1 hit
PRINTSiPR01591 DNABINDNGFIS
PR01590 HTHFIS
SUPFAMiSSF46689 SSF46689, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL
60 70 80 90
YELVLAEVEQ PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN
Length:98
Mass (Da):11,240
Last modified:May 10, 2005 - v1
Checksum:i2E339BFCFCDB163C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58389.1
BA000007 Genomic DNA Translation: BAB37556.1
PIRiA85991
E91145
RefSeqiNP_312160.1, NC_002695.1
WP_000462905.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58389; AAG58389; Z4621
BAB37556; BAB37556; BAB37556
GeneIDi8911232
916019
KEGGiece:Z4621
ecs:ECs4133
PATRICifig|386585.9.peg.4316

Similar proteinsi

Entry informationi

Entry nameiFIS_ECO57
AccessioniPrimary (citable) accession number: P0A6R5
Secondary accession number(s): P11028, P37404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health