Reviewed,
UniProtKB/Swiss-Prot P0A6R1 (FABH_ECOL6)
Last modified
November 3, 2009.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 3 EC=2.3.1.180 Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase III Beta-ketoacyl-ACP synthase III Short name=KAS III EcFabH | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O6 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 217992 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 317 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain By similarity. |
| Catalytic activity | Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815 |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Domain | The last Arg residue of the ACP-binding site is essential for the weak association between ACP/acpP and fabH. HAMAP MF_01815 |
| Miscellaneous | Inhibited by the SB418011 antibiotic. Not inhibited by cerulenin and thiolactomycin By similarity. |
| Sequence similarities | Belongs to the fabH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Lipid synthesis |
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP beta-ketoacyl-acyl-carrier-protein synthase III activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 317 | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815 | PRO_0000110425 | |||||
Regions | |||||||||
| Region | 245 – 249 | 5 | ACP-binding By similarity | ||||||
Sites | |||||||||
| Active site | 112 | 1 | By similarity | ||||||
| Active site | 244 | 1 | By similarity | ||||||
| Active site | 274 | 1 | By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AE014075 Genomic DNA. Translation: AAN79831.1. | |
| RefSeq | NP_753271.1. |
3D structure databases | |
| SMR | P0A6R1. Positions 1-317. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1035060. |
| GenomeReviews | Gene locus c1360 in contig AE014075_GR. |
| KEGG | ecc:c1360. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P0A6R1. |
| OMA | VATITHF. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.180. 292881. |
Family and domain databases | |
| HAMAP | MF_01815. [Tree] |
| InterPro | IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. IPR016038. Thiolase-like_subgr. [Graphical view] |
| Gene3D | G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits. |
| Pfam | PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00747. fabH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | FABH_ECOL6 | ||||||||
| Accession | Primary (citable) accession number: P0A6R1 Secondary accession number(s): P24249 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


