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Protein

Probable GTP-binding protein EngB

Gene

engB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for normal cell division and for the maintenance of normal septation. Depletion of this protein leads to a severe reduction in growth rate and to extensive filamentation, with a block beyond the stage of segregation. Essential for bacteria survival.UniRule annotation1 Publication

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40MagnesiumUniRule annotation1
Metal bindingi62MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 40GTPUniRule annotation8
Nucleotide bindingi60 – 64GTPUniRule annotation5
Nucleotide bindingi78 – 81GTPUniRule annotation4
Nucleotide bindingi145 – 148GTPUniRule annotation4
Nucleotide bindingi178 – 180GTPUniRule annotation3

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: EcoCyc
  • magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11203-MONOMER.
ECOL316407:JW5930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable GTP-binding protein EngBUniRule annotation
Gene namesi
Name:engBUniRule annotation
Synonyms:yihA
Ordered Locus Names:b3865, JW5930
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11203. engB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001577471 – 210Probable GTP-binding protein EngBAdd BLAST210

Proteomic databases

EPDiP0A6P7.
PaxDbiP0A6P7.
PRIDEiP0A6P7.

Interactioni

Protein-protein interaction databases

BioGridi4262625. 408 interactors.
DIPiDIP-48178N.
STRINGi511145.b3865.

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 17Combined sources6
Helixi18 – 20Combined sources3
Beta strandi26 – 33Combined sources8
Helixi39 – 43Combined sources5
Turni44 – 46Combined sources3
Beta strandi65 – 71Combined sources7
Beta strandi74 – 78Combined sources5
Helixi92 – 105Combined sources14
Beta strandi109 – 117Combined sources9
Helixi124 – 135Combined sources12
Beta strandi140 – 145Combined sources6
Helixi147 – 149Combined sources3
Helixi152 – 166Combined sources15
Helixi167 – 169Combined sources3
Beta strandi173 – 177Combined sources5
Turni180 – 183Combined sources4
Helixi186 – 197Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUIX-ray2.00A/B1-210[»]
ProteinModelPortaliP0A6P7.
SMRiP0A6P7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6P7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 199EngB-type GUniRule annotationAdd BLAST175

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.UniRule annotation
Contains 1 EngB-type G (guanine nucleotide-binding) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WHM. Bacteria.
COG0218. LUCA.
HOGENOMiHOG000009832.
InParanoidiP0A6P7.
KOiK03978.
OMAiKQHWQRH.
PhylomeDBiP0A6P7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00321. GTPase_EngB. 1 hit.
InterProiIPR030393. G_ENGB_dom.
IPR019987. GTP-bd_ribosome_bio_YsxC.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03598. GTPase_YsxC. 1 hit.
PROSITEiPS51706. G_ENGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A6P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLNYQQTH FVMSAPDIRH LPSDTGIEVA FAGRSNAGKS SALNTLTNQK
60 70 80 90 100
SLARTSKTPG RTQLINLFEV ADGKRLVDLP GYGYAEVPEE MKRKWQRALG
110 120 130 140 150
EYLEKRQSLQ GLVVLMDIRH PLKDLDQQMI EWAVDSNIAV LVLLTKADKL
160 170 180 190 200
ASGARKAQLN MVREAVLAFN GDVQVETFSS LKKQGVDKLR QKLDTWFSEM
210
QPVEETQDGE
Length:210
Mass (Da):23,561
Last modified:June 7, 2005 - v1
Checksum:i11BCA2ED59220C0D
GO

Sequence cautioni

The sequence AAA24403 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB02999 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE77444 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01663 Genomic DNA. Translation: AAA24403.1. Different initiation.
L19201 Genomic DNA. Translation: AAB02999.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76862.3.
AP009048 Genomic DNA. Translation: BAE77444.1. Different initiation.
PIRiS40810.
RefSeqiNP_418301.3. NC_000913.3.
WP_000183349.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76862; AAC76862; b3865.
BAE77444; BAE77444; BAE77444.
GeneIDi948358.
KEGGiecj:JW5930.
eco:b3865.
PATRICi32123229. VBIEscCol129921_3975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01663 Genomic DNA. Translation: AAA24403.1. Different initiation.
L19201 Genomic DNA. Translation: AAB02999.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76862.3.
AP009048 Genomic DNA. Translation: BAE77444.1. Different initiation.
PIRiS40810.
RefSeqiNP_418301.3. NC_000913.3.
WP_000183349.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PUIX-ray2.00A/B1-210[»]
ProteinModelPortaliP0A6P7.
SMRiP0A6P7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262625. 408 interactors.
DIPiDIP-48178N.
STRINGi511145.b3865.

Proteomic databases

EPDiP0A6P7.
PaxDbiP0A6P7.
PRIDEiP0A6P7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76862; AAC76862; b3865.
BAE77444; BAE77444; BAE77444.
GeneIDi948358.
KEGGiecj:JW5930.
eco:b3865.
PATRICi32123229. VBIEscCol129921_3975.

Organism-specific databases

EchoBASEiEB1188.
EcoGeneiEG11203. engB.

Phylogenomic databases

eggNOGiENOG4105WHM. Bacteria.
COG0218. LUCA.
HOGENOMiHOG000009832.
InParanoidiP0A6P7.
KOiK03978.
OMAiKQHWQRH.
PhylomeDBiP0A6P7.

Enzyme and pathway databases

BioCyciEcoCyc:EG11203-MONOMER.
ECOL316407:JW5930-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A6P7.
PROiP0A6P7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00321. GTPase_EngB. 1 hit.
InterProiIPR030393. G_ENGB_dom.
IPR019987. GTP-bd_ribosome_bio_YsxC.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03598. GTPase_YsxC. 1 hit.
PROSITEiPS51706. G_ENGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENGB_ECOLI
AccessioniPrimary (citable) accession number: P0A6P7
Secondary accession number(s): P24253, P76771, Q2M8G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.