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Protein

Co-chaperone protein HscB

Gene

hscB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciEcoCyc:EG12131-MONOMER
MetaCyc:EG12131-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Co-chaperone protein HscB
Alternative name(s):
Hsc20
Gene namesi
Name:hscB
Synonyms:yfhE
Ordered Locus Names:b2527, JW2511
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12131 hscB

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • iron-sulfur cluster transfer complex Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000709661 – 171Co-chaperone protein HscBAdd BLAST171

Proteomic databases

PaxDbiP0A6L9
PRIDEiP0A6L9

Interactioni

Subunit structurei

Interacts with HscA and stimulates its ATPase activity. Interacts with IscU.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4263037, 42 interactors
DIPiDIP-47847N
IntActiP0A6L9, 21 interactors
STRINGi316385.ECDH10B_2694

Structurei

Secondary structure

1171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 6Combined sources5
Beta strandi11 – 13Combined sources3
Helixi17 – 30Combined sources14
Helixi33 – 36Combined sources4
Helixi41 – 62Combined sources22
Helixi64 – 73Combined sources10
Turni74 – 76Combined sources3
Beta strandi82 – 84Combined sources3
Helixi89 – 108Combined sources20
Helixi111 – 137Combined sources27
Helixi141 – 165Combined sources25
Turni166 – 169Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FPOX-ray1.80A/B/C1-171[»]
ProteinModelPortaliP0A6L9
SMRiP0A6L9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6L9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 74JAdd BLAST73

Sequence similaritiesi

Belongs to the HscB family.Curated

Phylogenomic databases

eggNOGiENOG4108SWN Bacteria
COG1076 LUCA
HOGENOMiHOG000262077
InParanoidiP0A6L9
KOiK04082
OMAiLRVWGFW
PhylomeDBiP0A6L9

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.20.1280.20, 1 hit
HAMAPiMF_00682 HscB, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR004640 HscB
IPR036386 HscB_C_sf
IPR009073 HscB_oligo_C
IPR036869 J_dom_sf
PANTHERiPTHR14021 PTHR14021, 1 hit
PfamiView protein in Pfam
PF07743 HSCB_C, 1 hit
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF47144 SSF47144, 1 hit
TIGRFAMsiTIGR00714 hscB, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFTLFGLP ARYQLDTQAL SLRFQDLQRQ YHPDKFASGS QAEQLAAVQQ
60 70 80 90 100
SATINQAWQT LRHPLMRAEY LLSLHGFDLA SEQHTVRDTA FLMEQLELRE
110 120 130 140 150
ELDEIEQAKD EARLESFIKR VKKMFDTRHQ LMVEQLDNET WDAAADTVRK
160 170
LRFLDKLRSS AEQLEEKLLD F
Length:171
Mass (Da):20,138
Last modified:May 10, 2005 - v1
Checksum:i095193EE98AA60C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01827 Unassigned DNA Translation: AAA18299.1
U00096 Genomic DNA Translation: AAC75580.1
AP009048 Genomic DNA Translation: BAA16421.1
U05338 Genomic DNA No translation available.
PIRiA36958
RefSeqiNP_417022.1, NC_000913.3
WP_000384413.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75580; AAC75580; b2527
BAA16421; BAA16421; BAA16421
GeneIDi946995
KEGGiecj:JW2511
eco:b2527
PATRICifig|1411691.4.peg.4207

Similar proteinsi

Entry informationi

Entry nameiHSCB_ECOLI
AccessioniPrimary (citable) accession number: P0A6L9
Secondary accession number(s): P36540
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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