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P0A6L7

- UXAB_ECOLI

UniProt

P0A6L7 - UXAB_ECOLI

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Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 2912NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. NAD binding Source: EcoCyc
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-galacturonate catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:ALTRO-OXIDOREDUCT-MONOMER.
ECOL316407:JW1514-MONOMER.
MetaCyc:ALTRO-OXIDOREDUCT-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductase (EC:1.1.1.58)
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene namesi
Name:uxaB
Ordered Locus Names:b1521, JW1514
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11065. uxaB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Altronate oxidoreductasePRO_0000170742Add
BLAST

Proteomic databases

PaxDbiP0A6L7.
PRIDEiP0A6L7.

Expressioni

Inductioni

By galacturonate, tagaturonate and fructuronate. Its expression is subjected to catabolite repression by glucose.

Gene expression databases

GenevestigatoriP0A6L7.

Interactioni

Protein-protein interaction databases

IntActiP0A6L7. 7 interactions.
STRINGi511145.b1521.

Structurei

3D structure databases

ProteinModelPortaliP0A6L7.
SMRiP0A6L7. Positions 17-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000029586.
InParanoidiP0A6L7.
KOiK00041.
OMAiHNTFCST.
OrthoDBiEOG6CVVB8.
PhylomeDBiP0A6L7.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A6L7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV
60 70 80 90 100
VRPIETSFPP SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS
110 120 130 140 150
EYDEFLKLAH NPEMRFVFSN TTEAGISYHA GDKFDDAPAV SYPAKLTRLL
160 170 180 190 200
FERFSHFNGA LDKGWIIIPC ELIDYNGDAL RELVLRYAQE WALPEAFIQW
210 220 230 240 250
LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT AEHFYLFVIQ
260 270 280 290 300
GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG
310 320 330 340 350
LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP
360 370 380 390 400
YIKHQLLSIA LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY
410 420 430 440 450
RGERNGETYP VQDDAHWLER YQQLWSQHRD RVIGTQELVA IVLAEKDHWE
460 470 480
QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC
Length:483
Mass (Da):54,808
Last modified:May 10, 2005 - v1
Checksum:iAFA4677CF35BC2E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13327 Genomic DNA. Translation: BAA02586.1.
U00096 Genomic DNA. Translation: AAT48131.1.
AP009048 Genomic DNA. Translation: BAA15204.1.
M15737 Genomic DNA. Translation: AAA24757.1.
PIRiD64906.
RefSeqiYP_025302.1. NC_000913.3.
YP_489784.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAT48131; AAT48131; b1521.
BAA15204; BAA15204; BAA15204.
GeneIDi12931236.
945542.
KEGGiecj:Y75_p1496.
eco:b1521.
PATRICi32118338. VBIEscCol129921_1589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13327 Genomic DNA. Translation: BAA02586.1 .
U00096 Genomic DNA. Translation: AAT48131.1 .
AP009048 Genomic DNA. Translation: BAA15204.1 .
M15737 Genomic DNA. Translation: AAA24757.1 .
PIRi D64906.
RefSeqi YP_025302.1. NC_000913.3.
YP_489784.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0A6L7.
SMRi P0A6L7. Positions 17-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0A6L7. 7 interactions.
STRINGi 511145.b1521.

Proteomic databases

PaxDbi P0A6L7.
PRIDEi P0A6L7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT48131 ; AAT48131 ; b1521 .
BAA15204 ; BAA15204 ; BAA15204 .
GeneIDi 12931236.
945542.
KEGGi ecj:Y75_p1496.
eco:b1521.
PATRICi 32118338. VBIEscCol129921_1589.

Organism-specific databases

EchoBASEi EB1058.
EcoGenei EG11065. uxaB.

Phylogenomic databases

eggNOGi COG0246.
HOGENOMi HOG000029586.
InParanoidi P0A6L7.
KOi K00041.
OMAi HNTFCST.
OrthoDBi EOG6CVVB8.
PhylomeDBi P0A6L7.

Enzyme and pathway databases

UniPathwayi UPA00246 .
BioCyci EcoCyc:ALTRO-OXIDOREDUCT-MONOMER.
ECOL316407:JW1514-MONOMER.
MetaCyc:ALTRO-OXIDOREDUCT-MONOMER.

Miscellaneous databases

PROi P0A6L7.

Gene expression databases

Genevestigatori P0A6L7.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_00670. Altron_oxidoreduct.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mizobuchi K.
    Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: SEQUENCE REVISION TO 332.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "A DNA sequence containing the control sites for the uxaB gene of Escherichia coli."
    Blanco C., Mata-Gilsinger M.
    J. Gen. Microbiol. 132:697-705(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45, PROTEIN SEQUENCE OF 1-4.
    Strain: K12.

Entry informationi

Entry nameiUXAB_ECOLI
AccessioniPrimary (citable) accession number: P0A6L7
Secondary accession number(s): P24214, P78064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3