Reviewed, UniProtKB/Swiss-Prot P0A6L7 (UXAB_ECOLI)

Names and originHide

Protein names

Recommended name:
Altronate oxidoreductase
EC=1.1.1.58

Alternative name(s):
Tagaturonate reductase
Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	b1521, JW1514

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributesHide

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)Hide

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Induction	By galacturonate, tagaturonate and fructuronate. Its expression is subjected to catabolite repression by glucose. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

OntologiesHide

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	D-galacturonate catabolic process Inferred from mutant phenotype. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from direct assay. Source: UniProtKB tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Altronate oxidoreductase HAMAP MF_00670		PRO_0000170742
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

SequencesHide

	Sequence		Length	Mass (Da)
	P0A6L7-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: AFA4677CF35BC2E0	FASTA	483	54,808
	10 20 30 40 50 60 MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV VRPIETSFPP 70 80 90 100 110 120 SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS EYDEFLKLAH NPEMRFVFSN 130 140 150 160 170 180 TTEAGISYHA GDKFDDAPAV SYPAKLTRLL FERFSHFNGA LDKGWIIIPC ELIDYNGDAL 190 200 210 220 230 240 RELVLRYAQE WALPEAFIQW LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT 250 260 270 280 290 300 AEHFYLFVIQ GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 310 320 330 340 350 360 LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP YIKHQLLSIA 370 380 390 400 410 420 LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY RGERNGETYP VQDDAHWLER 430 440 450 460 470 480 YQQLWSQHRD RVIGTQELVA IVLAEKDHWE QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC

ReferencesHide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mizobuchi K. Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:363-377(1996) [PubMed: 9097039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005." Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R., Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T., Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H., Thomson N.R., Wishart D., Wanner B.L. Nucleic Acids Res. 34:1-9(2006) [PubMed: 16397293] [Abstract] Cited for: SEQUENCE REVISION TO 332.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]	"A DNA sequence containing the control sites for the uxaB gene of Escherichia coli." Blanco C., Mata-Gilsinger M. J. Gen. Microbiol. 132:697-705(1986) [PubMed: 3525742] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45, PROTEIN SEQUENCE OF 1-4. Strain: K12.

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	D13327 Genomic DNA. Translation: BAA02586.1. U00096 Genomic DNA. Translation: AAT48131.1. AP009048 Genomic DNA. Translation: BAA15204.1. M15737 Genomic DNA. Translation: AAA24757.1.
PIR	D64906.
RefSeq	AP_002142.1. YP_025302.1.
3D structure databases
SMR	P0A6L7. Positions 4-482.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0A6L7. 7 interactions.
STRING	P0A6L7.
Genome annotation databases
EnsemblBacteria	EBESCT00000004048; EBESCP00000004048; EBESCG00000003304. EBESCT00000016544; EBESCP00000015835; EBESCG00000015604.
GeneID	945542.
GenomeReviews	Gene locus JW1514 in contig AP009048_GR. Gene locus b1521 in contig U00096_GR.
KEGG	ecj:JW1514. eco:b1521.
Organism-specific databases
EchoBASE	EB1058.
EcoGene	EG11065. uxaB.
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HBG297101.
OMA	MTKYRTR.
ProtClustDB	PRK03643.
Enzyme and pathway databases
BioCyc	EcoCyc:ALTRO-OXIDOREDUCT-MONOMER. MetaCyc:ALTRO-OXIDOREDUCT-MONOMER.
Gene expression databases
Genevestigator	P0A6L7.
Family and domain databases
HAMAP	MF_00670. Altron_oxidoreduct. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C_like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
ProtoNet	Search...

Entry informationHide

Entry name

UXAB_ECOLI

Accession

Primary (citable) accession number: P0A6L7
Secondary accession number(s): P24214, P78064

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	July 13, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)