Reviewed,
UniProtKB/Swiss-Prot P0A6L7 (UXAB_ECOLI)
Last modified
July 13, 2010.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and originHide
| Protein names | Recommended name: Altronate oxidoreductase EC=1.1.1.58 Alternative name(s): Tagaturonate reductase Tagaturonate dehydrogenase | ||||
| Gene names |
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| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributesHide
| Sequence length | 483 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)Hide
| Catalytic activity | D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670 |
| Pathway | Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670 |
| Induction | By galacturonate, tagaturonate and fructuronate. Its expression is subjected to catabolite repression by glucose. HAMAP MF_00670 |
| Sequence similarities | Belongs to the mannitol dehydrogenase family. UxaB subfamily. |
OntologiesHide
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | D-galacturonate catabolic process Inferred from mutant phenotype. Source: UniProtKB oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAD or NADH binding Inferred from direct assay. Source: UniProtKB tagaturonate reductase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)Hide
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 483 | 483 | Altronate oxidoreductase HAMAP MF_00670 | PRO_0000170742 | |||||
Regions | |||||||||
| Nucleotide binding | 18 – 29 | 12 | NAD By similarity | ||||||
SequencesHide
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ReferencesHide
Cross-referencesHide
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D13327 Genomic DNA. Translation: BAA02586.1. U00096 Genomic DNA. Translation: AAT48131.1. AP009048 Genomic DNA. Translation: BAA15204.1. M15737 Genomic DNA. Translation: AAA24757.1. |
| PIR | D64906. |
| RefSeq | AP_002142.1. YP_025302.1. |
3D structure databases | |
| SMR | P0A6L7. Positions 4-482. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P0A6L7. 7 interactions. |
| STRING | P0A6L7. |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000004048; EBESCP00000004048; EBESCG00000003304. EBESCT00000016544; EBESCP00000015835; EBESCG00000015604. |
| GeneID | 945542. |
| GenomeReviews | Gene locus JW1514 in contig AP009048_GR. Gene locus b1521 in contig U00096_GR. |
| KEGG | ecj:JW1514. eco:b1521. |
Organism-specific databases | |
| EchoBASE | EB1058. |
| EcoGene | EG11065. uxaB. |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0246. |
| HOGENOM | HBG297101. |
| OMA | MTKYRTR. |
| ProtClustDB | PRK03643. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:ALTRO-OXIDOREDUCT-MONOMER. MetaCyc:ALTRO-OXIDOREDUCT-MONOMER. |
Gene expression databases | |
| Genevestigator | P0A6L7. |
Family and domain databases | |
| HAMAP | MF_00670. Altron_oxidoreduct. [Tree] |
| InterPro | IPR008927. 6-PGluconate_DH_C_like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view] |
| SUPFAM | SSF48179. 6DGDH_C_like. 1 hit. |
| ProtoNet | Search... |
Entry informationHide
| Entry name | UXAB_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P0A6L7 Secondary accession number(s): P24214, P78064 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documentsHide
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


