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P0A6L7

- UXAB_ECOLI

UniProt

P0A6L7 - UXAB_ECOLI

Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-altronate + NAD+ = D-tagaturonate + NADH.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 2912NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. NAD binding Source: EcoCyc
    2. tagaturonate reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-galacturonate catabolic process Source: EcoCyc

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciEcoCyc:ALTRO-OXIDOREDUCT-MONOMER.
    ECOL316407:JW1514-MONOMER.
    MetaCyc:ALTRO-OXIDOREDUCT-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Altronate oxidoreductase (EC:1.1.1.58)
    Alternative name(s):
    Tagaturonate dehydrogenase
    Tagaturonate reductase
    Gene namesi
    Name:uxaB
    Ordered Locus Names:b1521, JW1514
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11065. uxaB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Altronate oxidoreductasePRO_0000170742Add
    BLAST

    Proteomic databases

    PaxDbiP0A6L7.
    PRIDEiP0A6L7.

    Expressioni

    Inductioni

    By galacturonate, tagaturonate and fructuronate. Its expression is subjected to catabolite repression by glucose.

    Gene expression databases

    GenevestigatoriP0A6L7.

    Interactioni

    Protein-protein interaction databases

    IntActiP0A6L7. 7 interactions.
    STRINGi511145.b1521.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A6L7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000029586.
    KOiK00041.
    OMAiHNTFCST.
    OrthoDBiEOG6CVVB8.
    PhylomeDBiP0A6L7.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00670. Altron_oxidoreduct.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A6L7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV    50
    VRPIETSFPP SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS 100
    EYDEFLKLAH NPEMRFVFSN TTEAGISYHA GDKFDDAPAV SYPAKLTRLL 150
    FERFSHFNGA LDKGWIIIPC ELIDYNGDAL RELVLRYAQE WALPEAFIQW 200
    LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT AEHFYLFVIQ 250
    GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG 300
    LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP 350
    YIKHQLLSIA LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY 400
    RGERNGETYP VQDDAHWLER YQQLWSQHRD RVIGTQELVA IVLAEKDHWE 450
    QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC 483
    Length:483
    Mass (Da):54,808
    Last modified:May 10, 2005 - v1
    Checksum:iAFA4677CF35BC2E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13327 Genomic DNA. Translation: BAA02586.1.
    U00096 Genomic DNA. Translation: AAT48131.1.
    AP009048 Genomic DNA. Translation: BAA15204.1.
    M15737 Genomic DNA. Translation: AAA24757.1.
    PIRiD64906.
    RefSeqiYP_025302.1. NC_000913.3.
    YP_489784.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAT48131; AAT48131; b1521.
    BAA15204; BAA15204; BAA15204.
    GeneIDi12931236.
    945542.
    KEGGiecj:Y75_p1496.
    eco:b1521.
    PATRICi32118338. VBIEscCol129921_1589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13327 Genomic DNA. Translation: BAA02586.1 .
    U00096 Genomic DNA. Translation: AAT48131.1 .
    AP009048 Genomic DNA. Translation: BAA15204.1 .
    M15737 Genomic DNA. Translation: AAA24757.1 .
    PIRi D64906.
    RefSeqi YP_025302.1. NC_000913.3.
    YP_489784.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0A6L7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0A6L7. 7 interactions.
    STRINGi 511145.b1521.

    Proteomic databases

    PaxDbi P0A6L7.
    PRIDEi P0A6L7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT48131 ; AAT48131 ; b1521 .
    BAA15204 ; BAA15204 ; BAA15204 .
    GeneIDi 12931236.
    945542.
    KEGGi ecj:Y75_p1496.
    eco:b1521.
    PATRICi 32118338. VBIEscCol129921_1589.

    Organism-specific databases

    EchoBASEi EB1058.
    EcoGenei EG11065. uxaB.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000029586.
    KOi K00041.
    OMAi HNTFCST.
    OrthoDBi EOG6CVVB8.
    PhylomeDBi P0A6L7.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci EcoCyc:ALTRO-OXIDOREDUCT-MONOMER.
    ECOL316407:JW1514-MONOMER.
    MetaCyc:ALTRO-OXIDOREDUCT-MONOMER.

    Miscellaneous databases

    PROi P0A6L7.

    Gene expression databases

    Genevestigatori P0A6L7.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00670. Altron_oxidoreduct.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Mizobuchi K.
      Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. Cited for: SEQUENCE REVISION TO 332.
    5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    6. "A DNA sequence containing the control sites for the uxaB gene of Escherichia coli."
      Blanco C., Mata-Gilsinger M.
      J. Gen. Microbiol. 132:697-705(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45, PROTEIN SEQUENCE OF 1-4.
      Strain: K12.

    Entry informationi

    Entry nameiUXAB_ECOLI
    AccessioniPrimary (citable) accession number: P0A6L7
    Secondary accession number(s): P24214, P78064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3