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Protein

Phosphopentomutase

Gene

deoB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.

Cofactori

Mn2+CuratedNote: Binds 1 or 2 manganese ions.Curated

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101ManganeseBy similarity
Metal bindingi311 – 3111ManganeseBy similarity
Metal bindingi347 – 3471ManganeseBy similarity
Metal bindingi348 – 3481ManganeseBy similarity
Metal bindingi359 – 3591ManganeseBy similarity

GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • manganese ion binding Source: UniProtKB-HAMAP
  • phosphopentomutase activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:PPENTOMUT-MONOMER.
ECOL316407:JW4346-MONOMER.
MetaCyc:PPENTOMUT-MONOMER.
BRENDAi5.4.2.7. 2026.
UniPathwayiUPA00087; UER00173.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopentomutase (EC:5.4.2.7)
Alternative name(s):
Phosphodeoxyribomutase
Gene namesi
Name:deoB
Synonyms:drm, thyR
Ordered Locus Names:b4383, JW4346
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10220. deoB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407PhosphopentomutasePRO_0000199819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei287 – 2871N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP0A6K6.
PaxDbiP0A6K6.
PRIDEiP0A6K6.

Interactioni

Protein-protein interaction databases

BioGridi4263160. 8 interactions.
DIPiDIP-48057N.
IntActiP0A6K6. 6 interactions.
STRINGi511145.b4383.

Structurei

3D structure databases

ProteinModelPortaliP0A6K6.
SMRiP0A6K6. Positions 2-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.Curated

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
InParanoidiP0A6K6.
KOiK01839.
OMAiYLGNCHA.
PhylomeDBiP0A6K6.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A6K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAFIMVLD SFGIGATEDA ERFGDVGADT LGHIAEACAK GEADNGRKGP
60 70 80 90 100
LNLPNLTRLG LAKAHEGSTG FIPAGMDGNA EVIGAYAWAH EMSSGKDTPS
110 120 130 140 150
GHWEIAGVPV LFEWGYFSDH ENSFPQELLD KLVERANLPG YLGNCHSSGT
160 170 180 190 200
VILDQLGEEH MKTGKPIFYT SADSVFQIAC HEETFGLDKL YELCEIAREE
210 220 230 240 250
LTNGGYNIGR VIARPFIGDK AGNFQRTGNR HDLAVEPPAP TVLQKLVDEK
260 270 280 290 300
HGQVVSVGKI ADIYANCGIT KKVKATGLDA LFDATIKEMK EAGDNTIVFT
310 320 330 340 350
NFVDFDSSWG HRRDVAGYAA GLELFDRRLP ELMSLLRDDD ILILTADHGC
360 370 380 390 400
DPTWTGTDHT REHIPVLVYG PKVKPGSLGH RETFADIGQT LAKYFGTSDM

EYGKAMF
Length:407
Mass (Da):44,370
Last modified:March 29, 2005 - v1
Checksum:i516F3018DC77A077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97279.1.
U00096 Genomic DNA. Translation: AAC77336.1.
AP009048 Genomic DNA. Translation: BAE78372.1.
X00742 Genomic DNA. Translation: CAA25325.1.
PIRiS56607.
RefSeqiNP_418800.1. NC_000913.3.
WP_000816471.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77336; AAC77336; b4383.
BAE78372; BAE78372; BAE78372.
GeneIDi948910.
KEGGiecj:JW4346.
eco:b4383.
PATRICi32124382. VBIEscCol129921_4531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97279.1.
U00096 Genomic DNA. Translation: AAC77336.1.
AP009048 Genomic DNA. Translation: BAE78372.1.
X00742 Genomic DNA. Translation: CAA25325.1.
PIRiS56607.
RefSeqiNP_418800.1. NC_000913.3.
WP_000816471.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A6K6.
SMRiP0A6K6. Positions 2-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263160. 8 interactions.
DIPiDIP-48057N.
IntActiP0A6K6. 6 interactions.
STRINGi511145.b4383.

Proteomic databases

EPDiP0A6K6.
PaxDbiP0A6K6.
PRIDEiP0A6K6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77336; AAC77336; b4383.
BAE78372; BAE78372; BAE78372.
GeneIDi948910.
KEGGiecj:JW4346.
eco:b4383.
PATRICi32124382. VBIEscCol129921_4531.

Organism-specific databases

EchoBASEiEB0216.
EcoGeneiEG10220. deoB.

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
InParanoidiP0A6K6.
KOiK01839.
OMAiYLGNCHA.
PhylomeDBiP0A6K6.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00173.
BioCyciEcoCyc:PPENTOMUT-MONOMER.
ECOL316407:JW4346-MONOMER.
MetaCyc:PPENTOMUT-MONOMER.
BRENDAi5.4.2.7. 2026.

Miscellaneous databases

PROiP0A6K6.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOB_ECOLI
AccessioniPrimary (citable) accession number: P0A6K6
Secondary accession number(s): P07651, Q2M5T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: March 29, 2005
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.