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Protein

Pantothenate kinase

Gene

coaA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulationi

Regulated by feedback inhibition by CoA and its thioesters.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 1028ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: EcoCyc
  • pantothenate kinase activity Source: EcoCyc

GO - Biological processi

  • coenzyme A biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:PANTOTHENATE-KIN-MONOMER.
ECOL316407:JW3942-MONOMER.
MetaCyc:PANTOTHENATE-KIN-MONOMER.
BRENDAi2.7.1.33. 2026.
SABIO-RKP0A6I3.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase (EC:2.7.1.33)
Alternative name(s):
Pantothenic acid kinase
Rts protein
Gene namesi
Name:coaA
Synonyms:panK, rts
Ordered Locus Names:b3974, JW3942
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10922. coaA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Pantothenate kinasePRO_0000194426Add
BLAST

Proteomic databases

PaxDbiP0A6I3.
PRIDEiP0A6I3.

Interactioni

Protein-protein interaction databases

IntActiP0A6I3. 2 interactions.
STRINGi511145.b3974.

Structurei

Secondary structure

1
316
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 166Combined sources
Helixi17 – 226Combined sources
Helixi33 – 4210Combined sources
Beta strandi44 – 463Combined sources
Helixi48 – 536Combined sources
Helixi55 – 8026Combined sources
Beta strandi89 – 957Combined sources
Helixi101 – 11212Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi121 – 1255Combined sources
Helixi126 – 1294Combined sources
Helixi133 – 1397Combined sources
Helixi148 – 1503Combined sources
Helixi153 – 16311Combined sources
Turni164 – 1663Combined sources
Beta strandi170 – 1723Combined sources
Turni177 – 1804Combined sources
Beta strandi188 – 1903Combined sources
Beta strandi195 – 1995Combined sources
Turni201 – 2044Combined sources
Helixi207 – 2093Combined sources
Helixi219 – 2224Combined sources
Beta strandi224 – 2307Combined sources
Helixi233 – 24917Combined sources
Turni250 – 2534Combined sources
Helixi260 – 2634Combined sources
Helixi267 – 28014Combined sources
Helixi282 – 2887Combined sources
Helixi291 – 2966Combined sources
Beta strandi298 – 3036Combined sources
Helixi305 – 3073Combined sources
Beta strandi309 – 3157Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ESMX-ray2.50A/B/C/D1-316[»]
1ESNX-ray2.60A/B/C/D1-316[»]
1SQ5X-ray2.20A/B/C/D9-316[»]
ProteinModelPortaliP0A6I3.
SMRiP0A6I3. Positions 6-316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6I3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
InParanoidiP0A6I3.
KOiK00867.
OMAiLMQRKGF.
OrthoDBiEOG62C9GX.
PhylomeDBiP0A6I3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A6I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKEQTLMT PYLQFDRNQW AALRDSVPMT LSEDEIARLK GINEDLSLEE
60 70 80 90 100
VAEIYLPLSR LLNFYISSNL RRQAVLEQFL GTNGQRIPYI ISIAGSVAVG
110 120 130 140 150
KSTTARVLQA LLSRWPEHRR VELITTDGFL HPNQVLKERG LMKKKGFPES
160 170 180 190 200
YDMHRLVKFV SDLKSGVPNV TAPVYSHLIY DVIPDGDKTV VQPDILILEG
210 220 230 240 250
LNVLQSGMDY PHDPHHVFVS DFVDFSIYVD APEDLLQTWY INRFLKFREG
260 270 280 290 300
AFTDPDSYFH NYAKLTKEEA IKTAMTLWKE INWLNLKQNI LPTRERASLI
310
LTKSANHAVE EVRLRK
Length:316
Mass (Da):36,360
Last modified:March 29, 2005 - v1
Checksum:iDDDC1922C5C52A70
GO

Sequence cautioni

The sequence AAA23591.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAA76838.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36321 Genomic DNA. Translation: AAA76838.1. Different initiation.
M90071 Genomic DNA. Translation: AAA23590.1.
M90071 Genomic DNA. Translation: AAA23591.1. Different initiation.
U00006 Genomic DNA. Translation: AAC43076.1.
U00096 Genomic DNA. Translation: AAC76952.1.
AP009048 Genomic DNA. Translation: BAE77341.1.
PIRiA45727. BVECRS.
RefSeqiNP_418405.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76952; AAC76952; b3974.
BAE77341; BAE77341; BAE77341.
GeneIDi948479.
KEGGiecj:JW3942.
eco:b3974.
PATRICi32123469. VBIEscCol129921_4091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36321 Genomic DNA. Translation: AAA76838.1. Different initiation.
M90071 Genomic DNA. Translation: AAA23590.1.
M90071 Genomic DNA. Translation: AAA23591.1. Different initiation.
U00006 Genomic DNA. Translation: AAC43076.1.
U00096 Genomic DNA. Translation: AAC76952.1.
AP009048 Genomic DNA. Translation: BAE77341.1.
PIRiA45727. BVECRS.
RefSeqiNP_418405.1. NC_000913.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ESMX-ray2.50A/B/C/D1-316[»]
1ESNX-ray2.60A/B/C/D1-316[»]
1SQ5X-ray2.20A/B/C/D9-316[»]
ProteinModelPortaliP0A6I3.
SMRiP0A6I3. Positions 6-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0A6I3. 2 interactions.
STRINGi511145.b3974.

Chemistry

ChEMBLiCHEMBL5092.

Proteomic databases

PaxDbiP0A6I3.
PRIDEiP0A6I3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76952; AAC76952; b3974.
BAE77341; BAE77341; BAE77341.
GeneIDi948479.
KEGGiecj:JW3942.
eco:b3974.
PATRICi32123469. VBIEscCol129921_4091.

Organism-specific databases

EchoBASEiEB0915.
EcoGeneiEG10922. coaA.

Phylogenomic databases

eggNOGiENOG4105CS9. Bacteria.
COG1072. LUCA.
HOGENOMiHOG000248571.
InParanoidiP0A6I3.
KOiK00867.
OMAiLMQRKGF.
OrthoDBiEOG62C9GX.
PhylomeDBiP0A6I3.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciEcoCyc:PANTOTHENATE-KIN-MONOMER.
ECOL316407:JW3942-MONOMER.
MetaCyc:PANTOTHENATE-KIN-MONOMER.
BRENDAi2.7.1.33. 2026.
SABIO-RKP0A6I3.

Miscellaneous databases

EvolutionaryTraceiP0A6I3.
PROiP0A6I3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00215. Pantothen_kinase_1.
InterProiIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERiPTHR10285:SF7. PTHR10285:SF7. 2 hits.
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PIRSFiPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00554. panK_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli."
    Song W.-J., Jackowski S.
    J. Bacteriol. 174:6411-6417(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "coaA and rts are allelic and located at kilobase 3532 on the Escherichia coli physical map."
    Song W.-J., Jackowski S.
    J. Bacteriol. 174:1705-1706(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of the Escherichia coli rts gene."
    Flamm J.A., Friesen J.D., Otsuka A.J.
    Gene 74:555-558(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
    Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
    Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  6. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiCOAA_ECOLI
AccessioniPrimary (citable) accession number: P0A6I3
Secondary accession number(s): P15044, Q2M8R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.