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P0A6G5

- CITX_ECOLI

UniProt

P0A6G5 - CITX_ECOLI

Protein

Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Gene

citX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (29 Mar 2005)
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    Functioni

    Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.2 Publications

    Catalytic activityi

    2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate.

    GO - Molecular functioni

    1. holo-citrate lyase synthase activity Source: EcoCyc

    GO - Biological processi

    1. prosthetic group biosynthetic process Source: InterPro
    2. protein-phosphoribosyl dephospho-coenzyme A linkage Source: EcoCyc

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciEcoCyc:G6340-MONOMER.
    ECOL316407:JW0606-MONOMER.
    MetaCyc:G6340-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
    Alternative name(s):
    Apo-ACP nucleodityltransferase
    Holo-ACP synthase
    Holo-citrate lyase synthase
    Gene namesi
    Name:citX
    Synonyms:ybdU
    Ordered Locus Names:b0614, JW0606
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13540. citX.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Apo-citrate lyase phosphoribosyl-dephospho-CoA transferasePRO_0000214685Add
    BLAST

    Proteomic databases

    PaxDbiP0A6G5.
    PRIDEiP0A6G5.

    Expressioni

    Inductioni

    Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

    Gene expression databases

    GenevestigatoriP0A6G5.

    Interactioni

    Protein-protein interaction databases

    IntActiP0A6G5. 8 interactions.
    STRINGi511145.b0614.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A6G5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CitX family.Curated

    Phylogenomic databases

    eggNOGiCOG3697.
    HOGENOMiHOG000130710.
    KOiK05964.
    OMAiLWQHRWP.
    OrthoDBiEOG6T7NCD.
    PhylomeDBiP0A6G5.

    Family and domain databases

    HAMAPiMF_00398. CitX.
    InterProiIPR005551. CitX.
    [Graphical view]
    PfamiPF03802. CitX. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A6G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLLPELASH HAVSIPELLV SRDERQARQH VWLKRHPVPL VSFTVVAPGP    50
    IKDSEVTRRI FNHGVTALRA LAAKQGWQIQ EQAALVSASG PEGMLSIAAP 100
    ARDLKLATIE LEHSHPLGRL WDIDVLTPEG EILSRRDYSL PPRRCLLCEQ 150
    SAAVCARGKT HQLTDLLNRM EALLNDVDAC NVN 183
    Length:183
    Mass (Da):20,270
    Last modified:March 29, 2005 - v1
    Checksum:i22BC3420DABE06D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82598 Genomic DNA. Translation: AAB40814.1.
    U00096 Genomic DNA. Translation: AAC73715.1.
    AP009048 Genomic DNA. Translation: BAE76354.1.
    PIRiD64795.
    RefSeqiNP_415147.1. NC_000913.3.
    YP_488903.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73715; AAC73715; b0614.
    BAE76354; BAE76354; BAE76354.
    GeneIDi12931866.
    949084.
    KEGGiecj:Y75_p0603.
    eco:b0614.
    PATRICi32116408. VBIEscCol129921_0644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82598 Genomic DNA. Translation: AAB40814.1 .
    U00096 Genomic DNA. Translation: AAC73715.1 .
    AP009048 Genomic DNA. Translation: BAE76354.1 .
    PIRi D64795.
    RefSeqi NP_415147.1. NC_000913.3.
    YP_488903.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0A6G5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0A6G5. 8 interactions.
    STRINGi 511145.b0614.

    Proteomic databases

    PaxDbi P0A6G5.
    PRIDEi P0A6G5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73715 ; AAC73715 ; b0614 .
    BAE76354 ; BAE76354 ; BAE76354 .
    GeneIDi 12931866.
    949084.
    KEGGi ecj:Y75_p0603.
    eco:b0614.
    PATRICi 32116408. VBIEscCol129921_0644.

    Organism-specific databases

    EchoBASEi EB3310.
    EcoGenei EG13540. citX.

    Phylogenomic databases

    eggNOGi COG3697.
    HOGENOMi HOG000130710.
    KOi K05964.
    OMAi LWQHRWP.
    OrthoDBi EOG6T7NCD.
    PhylomeDBi P0A6G5.

    Enzyme and pathway databases

    BioCyci EcoCyc:G6340-MONOMER.
    ECOL316407:JW0606-MONOMER.
    MetaCyc:G6340-MONOMER.

    Miscellaneous databases

    PROi P0A6G5.

    Gene expression databases

    Genevestigatori P0A6G5.

    Family and domain databases

    HAMAPi MF_00398. CitX.
    InterProi IPR005551. CitX.
    [Graphical view ]
    Pfami PF03802. CitX. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03124. citrate_citX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts."
      Pos K.M., Dimroth P., Bott M.
      J. Bacteriol. 180:4160-4165(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME.
      Strain: K12.
    5. "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."
      Schneider K., Dimroth P., Bott M.
      FEBS Lett. 483:165-168(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Biosynthesis of the prosthetic group of citrate lyase."
      Schneider K., Dimroth P., Bott M.
      Biochemistry 39:9438-9450(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: BL21-DE3 and K12 / DH5-alpha.
    7. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
      Shimada T., Yamamoto K., Ishihama A.
      J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: OPERON STRUCTURE, INDUCTION.
      Strain: K12 / BW25113.

    Entry informationi

    Entry nameiCITX_ECOLI
    AccessioniPrimary (citable) accession number: P0A6G5
    Secondary accession number(s): P77563, Q2MBK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3