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P0A6G5

- CITX_ECOLI

UniProt

P0A6G5 - CITX_ECOLI

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Protein

Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Gene

citX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.2 Publications

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] = citrate lyase holo-[acyl-carrier protein] + diphosphate.2 Publications

GO - Molecular functioni

  1. holo-citrate lyase synthase activity Source: EcoCyc

GO - Biological processi

  1. prosthetic group biosynthetic process Source: InterPro
  2. protein-phosphoribosyl dephospho-coenzyme A linkage Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:G6340-MONOMER.
ECOL316407:JW0606-MONOMER.
MetaCyc:G6340-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.612 Publications)
Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase
Gene namesi
Name:citX
Synonyms:ybdU
Ordered Locus Names:b0614, JW0606
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13540. citX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Apo-citrate lyase phosphoribosyl-dephospho-CoA transferasePRO_0000214685Add
BLAST

Proteomic databases

PaxDbiP0A6G5.
PRIDEiP0A6G5.

Expressioni

Inductioni

Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

Gene expression databases

GenevestigatoriP0A6G5.

Interactioni

Protein-protein interaction databases

IntActiP0A6G5. 8 interactions.
STRINGi511145.b0614.

Structurei

3D structure databases

ProteinModelPortaliP0A6G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CitX family.Curated

Phylogenomic databases

eggNOGiCOG3697.
HOGENOMiHOG000130710.
InParanoidiP0A6G5.
KOiK05964.
OMAiLWQHRWP.
OrthoDBiEOG6T7NCD.
PhylomeDBiP0A6G5.

Family and domain databases

HAMAPiMF_00398. CitX.
InterProiIPR005551. CitX.
[Graphical view]
PfamiPF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A6G5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLLPELASH HAVSIPELLV SRDERQARQH VWLKRHPVPL VSFTVVAPGP
60 70 80 90 100
IKDSEVTRRI FNHGVTALRA LAAKQGWQIQ EQAALVSASG PEGMLSIAAP
110 120 130 140 150
ARDLKLATIE LEHSHPLGRL WDIDVLTPEG EILSRRDYSL PPRRCLLCEQ
160 170 180
SAAVCARGKT HQLTDLLNRM EALLNDVDAC NVN
Length:183
Mass (Da):20,270
Last modified:March 29, 2005 - v1
Checksum:i22BC3420DABE06D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40814.1.
U00096 Genomic DNA. Translation: AAC73715.1.
AP009048 Genomic DNA. Translation: BAE76354.1.
PIRiD64795.
RefSeqiNP_415147.1. NC_000913.3.
YP_488903.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73715; AAC73715; b0614.
BAE76354; BAE76354; BAE76354.
GeneIDi12931866.
949084.
KEGGiecj:Y75_p0603.
eco:b0614.
PATRICi32116408. VBIEscCol129921_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40814.1 .
U00096 Genomic DNA. Translation: AAC73715.1 .
AP009048 Genomic DNA. Translation: BAE76354.1 .
PIRi D64795.
RefSeqi NP_415147.1. NC_000913.3.
YP_488903.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0A6G5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0A6G5. 8 interactions.
STRINGi 511145.b0614.

Proteomic databases

PaxDbi P0A6G5.
PRIDEi P0A6G5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73715 ; AAC73715 ; b0614 .
BAE76354 ; BAE76354 ; BAE76354 .
GeneIDi 12931866.
949084.
KEGGi ecj:Y75_p0603.
eco:b0614.
PATRICi 32116408. VBIEscCol129921_0644.

Organism-specific databases

EchoBASEi EB3310.
EcoGenei EG13540. citX.

Phylogenomic databases

eggNOGi COG3697.
HOGENOMi HOG000130710.
InParanoidi P0A6G5.
KOi K05964.
OMAi LWQHRWP.
OrthoDBi EOG6T7NCD.
PhylomeDBi P0A6G5.

Enzyme and pathway databases

BioCyci EcoCyc:G6340-MONOMER.
ECOL316407:JW0606-MONOMER.
MetaCyc:G6340-MONOMER.

Miscellaneous databases

PROi P0A6G5.

Gene expression databases

Genevestigatori P0A6G5.

Family and domain databases

HAMAPi MF_00398. CitX.
InterProi IPR005551. CitX.
[Graphical view ]
Pfami PF03802. CitX. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03124. citrate_citX. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts."
    Pos K.M., Dimroth P., Bott M.
    J. Bacteriol. 180:4160-4165(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
    Strain: K12.
  5. "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."
    Schneider K., Dimroth P., Bott M.
    FEBS Lett. 483:165-168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  6. "Biosynthesis of the prosthetic group of citrate lyase."
    Schneider K., Dimroth P., Bott M.
    Biochemistry 39:9438-9450(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
    Strain: BL21-DE3 and K12 / DH5-alpha.
  7. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
    Shimada T., Yamamoto K., Ishihama A.
    J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: OPERON STRUCTURE, INDUCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiCITX_ECOLI
AccessioniPrimary (citable) accession number: P0A6G5
Secondary accession number(s): P77563, Q2MBK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3