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Protein

10 kDa chaperonin

Gene

groS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • chaperone cofactor-dependent protein refolding Source: EcoCyc
  • protein folding Source: CACAO
  • response to heat Source: EcoliWiki
  • response to unfolded protein Source: GO_Central
  • virion assembly Source: EcoliWiki

Keywordsi

Molecular functionChaperone
Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:EG10600-MONOMER
MetaCyc:EG10600-MONOMER
SABIO-RKiP0A6F9

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa chaperonin
Alternative name(s):
GroES protein
Protein Cpn10
Gene namesi
Name:groS
Synonyms:groES, mopB
Ordered Locus Names:b4142, JW4102
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10600 groS

Subcellular locationi

  • Cytoplasm 1 Publication
  • Note: Exclusively localized in foci, usually near 1 cell pole in mid-to-late exponential phase; polar localization depends on the minCDE operon. Foci form near midcell.

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • GroEL-GroES complex Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001747461 – 9710 kDa chaperoninAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-succinyllysine1 Publication1

Proteomic databases

EPDiP0A6F9
PaxDbiP0A6F9
PRIDEiP0A6F9

2D gel databases

SWISS-2DPAGEiP0A6F9

Interactioni

Subunit structurei

Heptamer of 7 subunits arranged in a ring.

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • identical protein binding Source: EcoCyc
  • unfolded protein binding Source: GO_Central

Protein-protein interaction databases

BioGridi4262198, 222 interactors
DIPiDIP-9835N
IntActiP0A6F9, 41 interactors
MINTiP0A6F9
STRINGi316385.ECDH10B_4335

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Beta strandi7 – 14Combined sources8
Turni20 – 23Combined sources4
Beta strandi37 – 43Combined sources7
Beta strandi45 – 47Combined sources3
Beta strandi51 – 53Combined sources3
Beta strandi64 – 67Combined sources4
Beta strandi74 – 78Combined sources5
Beta strandi81 – 87Combined sources7
Helixi88 – 90Combined sources3
Beta strandi91 – 96Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AONX-ray3.00O/P/Q/R/S/T/U1-97[»]
1EGSNMR-A19-27[»]
1GRUelectron microscopy12.50O/P/Q/R/S/T/U1-97[»]
1PCQX-ray2.81O/P/Q/R/S/T/U1-97[»]
1PF9X-ray2.99O/P/Q/R/S/T/U1-97[»]
1SVTX-ray2.81O/P/Q/R/S/T/U1-97[»]
1SX4X-ray3.00O/P/Q/R/S/T/U1-97[»]
2C7Celectron microscopy7.70O/P/Q/R/S/T/U1-97[»]
2C7Delectron microscopy8.70O/P/Q/R/S/T/U1-97[»]
3WVLX-ray3.79O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b1-97[»]
3ZPZelectron microscopy8.90O/P/Q/R/S/T/U1-97[»]
3ZQ0electron microscopy9.20O/P/Q/R/S/T/U1-97[»]
3ZQ1electron microscopy15.90O/P/Q/R/S/T/U1-97[»]
5OPXX-ray3.641/2/O/P/Q/R/S/T/U/V/W/X/Y/Z1-97[»]
ProteinModelPortaliP0A6F9
SMRiP0A6F9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6F9

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

eggNOGiENOG4105K5Y Bacteria
COG0234 LUCA
HOGENOMiHOG000133897
InParanoidiP0A6F9
KOiK04078
OMAiVMGENEI
PhylomeDBiP0A6F9

Family and domain databases

CDDicd00320 cpn10, 1 hit
Gene3Di2.30.33.40, 1 hit
HAMAPiMF_00580 CH10, 1 hit
InterProiView protein in InterPro
IPR020818 Chaperonin_GroES
IPR037124 Chaperonin_GroES_sf
IPR018369 Chaprnonin_Cpn10_CS
IPR011032 GroES-like_sf
PANTHERiPTHR10772 PTHR10772, 1 hit
PfamiView protein in Pfam
PF00166 Cpn10, 1 hit
PRINTSiPR00297 CHAPERONIN10
SMARTiView protein in SMART
SM00883 Cpn10, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
PROSITEiView protein in PROSITE
PS00681 CHAPERONINS_CPN10, 1 hit

Sequencei

Sequence statusi: Complete.

P0A6F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRPLHDRV IVKRKEVETK SAGGIVLTGS AAAKSTRGEV LAVGNGRILE
60 70 80 90
NGEVKPLDVK VGDIVIFNDG YGVKSEKIDN EEVLIMSESD ILAIVEA
Length:97
Mass (Da):10,387
Last modified:March 29, 2005 - v1
Checksum:i76829E09B11217EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89S → N in CAA30738 (PubMed:2901493).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07850 Genomic DNA Translation: CAA30697.1
X07899 Genomic DNA Translation: CAA30738.1
U14003 Genomic DNA Translation: AAA97041.1
U00096 Genomic DNA Translation: AAC77102.1
AP009048 Genomic DNA Translation: BAE78144.1
PIRiS03931 BVECGS
RefSeqiNP_418566.1, NC_000913.3
WP_001026276.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77102; AAC77102; b4142
BAE78144; BAE78144; BAE78144
GeneIDi948655
KEGGiecj:JW4102
eco:b4142
PATRICifig|1411691.4.peg.2558

Similar proteinsi

Entry informationi

Entry nameiCH10_ECOLI
AccessioniPrimary (citable) accession number: P0A6F9
Secondary accession number(s): P05380, Q2M6G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health