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P0A6F7

- CH60_ECO57

UniProt

P0A6F7 - CH60_ECO57

Protein

60 kDa chaperonin

Gene

groL

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein refolding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-5130-MONOMER.
    ECOO157:MOPA-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60 kDa chaperoninUniRule annotation
    Alternative name(s):
    GroEL proteinUniRule annotation
    Protein Cpn60UniRule annotation
    Gene namesi
    Name:groLUniRule annotation
    Synonyms:groELUniRule annotation, mopA
    Ordered Locus Names:Z5748, ECs5124
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 54854760 kDa chaperoninPRO_0000063360Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiP0A6F7.

    Interactioni

    Subunit structurei

    Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

    Protein-protein interaction databases

    IntActiP0A6F7. 1 interaction.
    MINTiMINT-1299311.
    STRINGi155864.Z5748.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A6F7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chaperonin (HSP60) family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0459.
    HOGENOMiHOG000076290.
    KOiK04077.
    OMAiVLFGNDA.
    OrthoDBiEOG6JDWBZ.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.50.7.10. 1 hit.
    HAMAPiMF_00600. CH60.
    InterProiIPR018370. Chaperonin_Cpn60_CS.
    IPR001844. Chaprnin_Cpn60.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00298. CHAPERONIN60.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02348. GroEL. 1 hit.
    PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A6F7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAKDVKFGN DARVKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGAPTIT    50
    KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQAII 100
    TEGLKAVAAG MNPMDLKRGI DKAVTAAVEE LKALSVPCSD SKAIAQVGTI 150
    SANSDETVGK LIAEAMDKVG KEGVITVEDG TGLQDELDVV EGMQFDRGYL 200
    SPYFINKPET GAVELESPFI LLADKKISNI REMLPVLEAV AKAGKPLLII 250
    AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIATLTGGTV 300
    ISEEIGMELE KATLEDLGQA KRVVINKDTT TIIDGVGEEA AIQGRVAQIR 350
    QQIEEATSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVEDAL 400
    HATRAAVEEG VVAGGGVALI RVASKLADLR GQNEDQNVGI KVALRAMEAP 450
    LRQIVLNCGE EPSVVANTVK GGDGNYGYNA ATEEYGNMID MGILDPTKVT 500
    RSALQYAASV AGLMITTECM VTDLPKNDAA DLGAAGGMGG MGGMGGMM 548
    Length:548
    Mass (Da):57,329
    Last modified:January 23, 2007 - v2
    Checksum:iCD3A0FB505F74AD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG59342.1.
    BA000007 Genomic DNA. Translation: BAB38547.1.
    PIRiD91269.
    RefSeqiNP_290776.1. NC_002655.2.
    NP_313151.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG59342; AAG59342; Z5748.
    BAB38547; BAB38547; BAB38547.
    GeneIDi913705.
    959980.
    KEGGiece:Z5748.
    ecs:ECs5124.
    PATRICi18359865. VBIEscCol44059_5068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG59342.1 .
    BA000007 Genomic DNA. Translation: BAB38547.1 .
    PIRi D91269.
    RefSeqi NP_290776.1. NC_002655.2.
    NP_313151.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0A6F7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0A6F7. 1 interaction.
    MINTi MINT-1299311.
    STRINGi 155864.Z5748.

    Proteomic databases

    PRIDEi P0A6F7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG59342 ; AAG59342 ; Z5748 .
    BAB38547 ; BAB38547 ; BAB38547 .
    GeneIDi 913705.
    959980.
    KEGGi ece:Z5748.
    ecs:ECs5124.
    PATRICi 18359865. VBIEscCol44059_5068.

    Phylogenomic databases

    eggNOGi COG0459.
    HOGENOMi HOG000076290.
    KOi K04077.
    OMAi VLFGNDA.
    OrthoDBi EOG6JDWBZ.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-5130-MONOMER.
    ECOO157:MOPA-MONOMER.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.50.7.10. 1 hit.
    HAMAPi MF_00600. CH60.
    InterProi IPR018370. Chaperonin_Cpn60_CS.
    IPR001844. Chaprnin_Cpn60.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00298. CHAPERONIN60.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02348. GroEL. 1 hit.
    PROSITEi PS00296. CHAPERONINS_CPN60. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiCH60_ECO57
    AccessioniPrimary (citable) accession number: P0A6F7
    Secondary accession number(s): P06139
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3