P0A6E7 (ATPE_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase epsilon chain

Alternative name(s):
ATP synthase F1 sector epsilon subunit
F-ATPase epsilon subunit

Gene names

Name:	atpC
Synonyms:	papG, uncC
Ordered Locus Names:	c4657

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

199310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane By similarity. HAMAP-Rule MF_00530
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00530.
Sequence similarities	Belongs to the ATPase epsilon chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell inner membrane Cell membrane Membrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP proton-transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 139	138	ATP synthase epsilon chain HAMAP-Rule MF_00530		PRO_0000188134

Sequences

	Sequence		Length	Mass (Da)
	P0A6E7 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 5EFF7DE911745A62	FASTA	139	15,068
	10 20 30 40 50 60 MAMTYHLDVV SAEQQMFSGL VEKIQVTGSE GELGIYPGHA PLLTAIKPGM IRIVKQHGHE 70 80 90 100 110 120 EFIYLSGGIL EVQPGNVTVL ADTAIRGQDL DEARAMEAKR KAEEHISSSH GDVDYAQASA 130 ELAKAIAQLR VIELTKKAM

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFT073 / ATCC 700928 / UPEC.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN83089.1.
RefSeq	NP_756515.1. NC_004431.1.
3D structure databases
ProteinModelPortal	P0A6E7.
SMR	P0A6E7. Positions 2-139.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-149427.
STRING	199310.c4657.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN83089; AAN83089; c4657.
GeneID	1040232.
KEGG	ecc:c4657.
PATRIC	18286995. VBIEscCol75197_4371.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000216025.
KO	K02114.
OMA	SAEASIF.
ProtClustDB	PRK00571.
Family and domain databases
Gene3D	2.60.15.10. 1 hit.
HAMAP	MF_00530. ATP_synth_epsil_bac.
InterPro	IPR001469. ATPase_F1-cplx_dsu/esu. IPR020547. ATPase_F1-cplx_dsu/esu_C. IPR020546. ATPase_F1-cplx_dsu/esu_N. [Graphical view]
PANTHER	PTHR13822. PTHR13822. 1 hit.
Pfam	PF00401. ATP-synt_DE. 1 hit. PF02823. ATP-synt_DE_N. 1 hit. [Graphical view]
ProDom	PD000944. ATPase_F1-cplx_dsu/esu. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF46604. ATPsynt_DE. 1 hit. SSF51344. ATPsynt_DE. 1 hit.
TIGRFAMs	TIGR01216. ATP_synt_epsi. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ATPE_ECOL6

Accession

Primary (citable) accession number: P0A6E7
Secondary accession number(s): P00832

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program