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Protein

ATP synthase epsilon chain

Gene

atpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-HAMAP
  • proton-transporting ATP synthase activity, rotational mechanism Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ATPC-MONOMER.
ECOL316407:JW3709-MONOMER.
MetaCyc:ATPC-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase epsilon chain
Alternative name(s):
ATP synthase F1 sector epsilon subunit
F-ATPase epsilon subunit
Gene namesi
Name:atpC
Synonyms:papG, uncC
Ordered Locus Names:b3731, JW3709
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10100. atpC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001881322 – 139ATP synthase epsilon chainAdd BLAST138

Proteomic databases

EPDiP0A6E6.
PaxDbiP0A6E6.
PRIDEiP0A6E6.

2D gel databases

SWISS-2DPAGEP0A6E6.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
atpGP0ABA64EBI-544362,EBI-544306

Protein-protein interaction databases

DIPiDIP-47828N.
IntActiP0A6E6. 7 interactors.
STRINGi511145.b3731.

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 13Combined sources9
Beta strandi15 – 35Combined sources21
Beta strandi42 – 46Combined sources5
Beta strandi48 – 55Combined sources8
Turni56 – 58Combined sources3
Beta strandi60 – 65Combined sources6
Beta strandi68 – 72Combined sources5
Beta strandi77 – 81Combined sources5
Helixi88 – 103Combined sources16
Beta strandi110 – 112Combined sources3
Helixi115 – 133Combined sources19
Helixi134 – 137Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQTX-ray2.30A4-139[»]
1BSHNMR-A2-139[»]
1BSNNMR-A2-139[»]
1FS0X-ray2.10E2-139[»]
1QO1X-ray3.90J4-139[»]
3OAAX-ray3.26H/P/X/f2-139[»]
ProteinModelPortaliP0A6E6.
SMRiP0A6E6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6E6.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Phylogenomic databases

eggNOGiENOG4105KNM. Bacteria.
COG0355. LUCA.
HOGENOMiHOG000216025.
InParanoidiP0A6E6.
KOiK02114.
OMAiMTVHCDI.
PhylomeDBiP0A6E6.

Family and domain databases

CDDicd12152. F1-ATPase_delta. 1 hit.
Gene3Di2.60.15.10. 1 hit.
HAMAPiMF_00530. ATP_synth_epsil_bac. 1 hit.
InterProiIPR001469. ATP_synth_F1_dsu/esu.
IPR020547. ATP_synth_F1_dsu/esu_C.
IPR020546. ATP_synth_F1_dsu/esu_N.
[Graphical view]
PANTHERiPTHR13822. PTHR13822. 1 hit.
PfamiPF00401. ATP-synt_DE. 1 hit.
PF02823. ATP-synt_DE_N. 1 hit.
[Graphical view]
ProDomiPD000944. ATPase_F1-cplx_dsu/esu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46604. SSF46604. 1 hit.
SSF51344. SSF51344. 1 hit.
TIGRFAMsiTIGR01216. ATP_synt_epsi. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A6E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMTYHLDVV SAEQQMFSGL VEKIQVTGSE GELGIYPGHA PLLTAIKPGM
60 70 80 90 100
IRIVKQHGHE EFIYLSGGIL EVQPGNVTVL ADTAIRGQDL DEARAMEAKR
110 120 130
KAEEHISSSH GDVDYAQASA ELAKAIAQLR VIELTKKAM
Length:139
Mass (Da):15,068
Last modified:January 23, 2007 - v2
Checksum:i5EFF7DE911745A62
GO

Sequence cautioni

The sequence CAA23528 differs from that shown. Reason: Frameshift at position 132.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13E → K AA sequence (PubMed:9868784).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01594 Genomic DNA. Translation: AAA24738.1.
X01631 Genomic DNA. Translation: CAA25783.1.
V00311 Genomic DNA. Translation: CAA23595.1.
M25464 Genomic DNA. Translation: AAA83876.1.
V00267 Genomic DNA. Translation: CAA23528.1. Frameshift.
L10328 Genomic DNA. Translation: AAA62083.1.
U00096 Genomic DNA. Translation: AAC76754.1.
AP009048 Genomic DNA. Translation: BAE77557.1.
PIRiB90106. PWECE.
RefSeqiNP_418187.1. NC_000913.3.
WP_001251965.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76754; AAC76754; b3731.
BAE77557; BAE77557; BAE77557.
GeneIDi948245.
KEGGiecj:JW3709.
eco:b3731.
PATRICi32122959. VBIEscCol129921_3855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01594 Genomic DNA. Translation: AAA24738.1.
X01631 Genomic DNA. Translation: CAA25783.1.
V00311 Genomic DNA. Translation: CAA23595.1.
M25464 Genomic DNA. Translation: AAA83876.1.
V00267 Genomic DNA. Translation: CAA23528.1. Frameshift.
L10328 Genomic DNA. Translation: AAA62083.1.
U00096 Genomic DNA. Translation: AAC76754.1.
AP009048 Genomic DNA. Translation: BAE77557.1.
PIRiB90106. PWECE.
RefSeqiNP_418187.1. NC_000913.3.
WP_001251965.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQTX-ray2.30A4-139[»]
1BSHNMR-A2-139[»]
1BSNNMR-A2-139[»]
1FS0X-ray2.10E2-139[»]
1QO1X-ray3.90J4-139[»]
3OAAX-ray3.26H/P/X/f2-139[»]
ProteinModelPortaliP0A6E6.
SMRiP0A6E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47828N.
IntActiP0A6E6. 7 interactors.
STRINGi511145.b3731.

Protein family/group databases

TCDBi3.A.2.1.1. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

2D gel databases

SWISS-2DPAGEP0A6E6.

Proteomic databases

EPDiP0A6E6.
PaxDbiP0A6E6.
PRIDEiP0A6E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76754; AAC76754; b3731.
BAE77557; BAE77557; BAE77557.
GeneIDi948245.
KEGGiecj:JW3709.
eco:b3731.
PATRICi32122959. VBIEscCol129921_3855.

Organism-specific databases

EchoBASEiEB0098.
EcoGeneiEG10100. atpC.

Phylogenomic databases

eggNOGiENOG4105KNM. Bacteria.
COG0355. LUCA.
HOGENOMiHOG000216025.
InParanoidiP0A6E6.
KOiK02114.
OMAiMTVHCDI.
PhylomeDBiP0A6E6.

Enzyme and pathway databases

BioCyciEcoCyc:ATPC-MONOMER.
ECOL316407:JW3709-MONOMER.
MetaCyc:ATPC-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A6E6.
PROiP0A6E6.

Family and domain databases

CDDicd12152. F1-ATPase_delta. 1 hit.
Gene3Di2.60.15.10. 1 hit.
HAMAPiMF_00530. ATP_synth_epsil_bac. 1 hit.
InterProiIPR001469. ATP_synth_F1_dsu/esu.
IPR020547. ATP_synth_F1_dsu/esu_C.
IPR020546. ATP_synth_F1_dsu/esu_N.
[Graphical view]
PANTHERiPTHR13822. PTHR13822. 1 hit.
PfamiPF00401. ATP-synt_DE. 1 hit.
PF02823. ATP-synt_DE_N. 1 hit.
[Graphical view]
ProDomiPD000944. ATPase_F1-cplx_dsu/esu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46604. SSF46604. 1 hit.
SSF51344. SSF51344. 1 hit.
TIGRFAMsiTIGR01216. ATP_synt_epsi. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATPE_ECOLI
AccessioniPrimary (citable) accession number: P0A6E6
Secondary accession number(s): P00832, Q2M849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.