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P0A6D6 (YDIB_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Quinate/shikimate dehydrogenase

EC=1.1.1.282
Alternative name(s):
NAD-dependent shikimate 5-dehydrogenase 2
Gene names
Name:ydiB
Ordered Locus Names:c2087
OrganismEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier199310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H. HAMAP-Rule MF_01578

Shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H. HAMAP-Rule MF_01578

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP-Rule MF_01578

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01578

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Quinate/shikimate dehydrogenase HAMAP-Rule MF_01578
PRO_0000136071

Regions

Nucleotide binding131 – 1355NAD By similarity
Nucleotide binding155 – 1584NAD By similarity
Nucleotide binding255 – 2595NAD By similarity

Sites

Active site711Proton acceptor Potential
Binding site1071Substrate By similarity
Binding site2051NAD; via amide nitrogen By similarity
Binding site2351NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A6D6 [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: C3D1415E03820A5A

FASTA28831,228
        10         20         30         40         50         60 
MDVTAKYELI GLMAYPIRHS LSPEMQNKAL EKAGLPFTYM AFEVDNDSFP GAIEGLKALK 

        70         80         90        100        110        120 
MRGTGVSMPN KQLACEYVDE LTPAAKLVGA INTIVNDDGY LRGYNTDGTG HIRAIKESGF 

       130        140        150        160        170        180 
DIKGKTMVLL GAGGASTAIG AQGAIEGLKE IKLFNRRDEF FDKALAFAQR VNENTDCVVT 

       190        200        210        220        230        240 
VTDLADQQAF AEALASADIL TNGTKVGMKP LENESLVNDI SLLHPGLLVT ECVYNPHMTK 

       250        260        270        280 
LLQQAQQAGC KTIDGYGMLL WQGAEQFTLW TGKDFPLEYV KQVMGFGA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014075 Genomic DNA. Translation: AAN80547.1.
RefSeqNP_753982.1. NC_004431.1.

3D structure databases

ProteinModelPortalP0A6D6.
SMRP0A6D6. Positions 5-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1283296.
STRING199310.c2087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN80547; AAN80547; c2087.
GeneID1036366.
KEGGecc:c2087.
PATRIC18282073. VBIEscCol75197_1953.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000237875.
KOK05887.
OMAVSFEIWT.
OrthoDBEOG64R67G.
ProtClustDBPRK12749.

Enzyme and pathway databases

BioCycECOL199310:C2087-MONOMER.
UniPathwayUPA00053; UER00087.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00222. Shikimate_DH_AroE.
MF_01578. Shikimate_DH_YdiB.
InterProIPR016040. NAD(P)-bd_dom.
IPR022872. Quinate/Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYDIB_ECOL6
AccessionPrimary (citable) accession number: P0A6D6
Secondary accession number(s): P28244, P77647
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways