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P0A6D6

- YDIB_ECOL6

UniProt

P0A6D6 - YDIB_ECOL6

Protein

Quinate/shikimate dehydrogenase

Gene

ydiB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H.UniRule annotation
    Shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711Proton acceptorUniRule annotation
    Binding sitei107 – 1071SubstrateUniRule annotation
    Binding sitei205 – 2051NAD; via amide nitrogenUniRule annotation
    Binding sitei235 – 2351NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi131 – 1355NADUniRule annotation
    Nucleotide bindingi155 – 1584NADUniRule annotation
    Nucleotide bindingi255 – 2595NADUniRule annotation

    GO - Molecular functioni

    1. quinate 3-dehydrogenase (NAD+) activity Source: UniProtKB-HAMAP
    2. quinate 3-dehydrogenase (NADP+) activity Source: UniProtKB-EC
    3. shikimate 3-dehydrogenase (NAD+) activity Source: UniProtKB-EC
    4. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciECOL199310:C2087-MONOMER.
    UniPathwayiUPA00053; UER00087.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinate/shikimate dehydrogenaseUniRule annotation (EC:1.1.1.282UniRule annotation)
    Alternative name(s):
    NAD-dependent shikimate 5-dehydrogenase 2UniRule annotation
    Gene namesi
    Name:ydiBUniRule annotation
    Ordered Locus Names:c2087
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Quinate/shikimate dehydrogenasePRO_0000136071Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    MINTiMINT-1283296.
    STRINGi199310.c2087.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A6D6.
    SMRiP0A6D6. Positions 5-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000237875.
    KOiK05887.
    OMAiERIWLGV.
    OrthoDBiEOG64R67G.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00222. Shikimate_DH_AroE.
    MF_01578. Shikimate_DH_YdiB.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR022872. Quinate/Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view]
    PfamiPF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A6D6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVTAKYELI GLMAYPIRHS LSPEMQNKAL EKAGLPFTYM AFEVDNDSFP    50
    GAIEGLKALK MRGTGVSMPN KQLACEYVDE LTPAAKLVGA INTIVNDDGY 100
    LRGYNTDGTG HIRAIKESGF DIKGKTMVLL GAGGASTAIG AQGAIEGLKE 150
    IKLFNRRDEF FDKALAFAQR VNENTDCVVT VTDLADQQAF AEALASADIL 200
    TNGTKVGMKP LENESLVNDI SLLHPGLLVT ECVYNPHMTK LLQQAQQAGC 250
    KTIDGYGMLL WQGAEQFTLW TGKDFPLEYV KQVMGFGA 288
    Length:288
    Mass (Da):31,228
    Last modified:June 7, 2005 - v1
    Checksum:iC3D1415E03820A5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80547.1.
    RefSeqiNP_753982.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN80547; AAN80547; c2087.
    GeneIDi1036366.
    KEGGiecc:c2087.
    PATRICi18282073. VBIEscCol75197_1953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80547.1 .
    RefSeqi NP_753982.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P0A6D6.
    SMRi P0A6D6. Positions 5-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1283296.
    STRINGi 199310.c2087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN80547 ; AAN80547 ; c2087 .
    GeneIDi 1036366.
    KEGGi ecc:c2087.
    PATRICi 18282073. VBIEscCol75197_1953.

    Phylogenomic databases

    HOGENOMi HOG000237875.
    KOi K05887.
    OMAi ERIWLGV.
    OrthoDBi EOG64R67G.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00087 .
    BioCyci ECOL199310:C2087-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00222. Shikimate_DH_AroE.
    MF_01578. Shikimate_DH_YdiB.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR022872. Quinate/Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view ]
    Pfami PF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiYDIB_ECOL6
    AccessioniPrimary (citable) accession number: P0A6D6
    Secondary accession number(s): P28244, P77647
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3