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P0A6D6

- YDIB_ECOL6

UniProt

P0A6D6 - YDIB_ECOL6

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Protein

Quinate/shikimate dehydrogenase

Gene
ydiB, c2087
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H.UniRule annotation
Shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Proton acceptor Reviewed prediction
Binding sitei107 – 1071Substrate By similarity
Binding sitei205 – 2051NAD; via amide nitrogen By similarity
Binding sitei235 – 2351NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi131 – 1355NAD By similarity
Nucleotide bindingi155 – 1584NAD By similarity
Nucleotide bindingi255 – 2595NAD By similarity

GO - Molecular functioni

  1. quinate 3-dehydrogenase (NAD+) activity Source: UniProtKB-HAMAP
  2. quinate 3-dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. shikimate 3-dehydrogenase (NAD+) activity Source: UniProtKB-EC
  4. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciECOL199310:C2087-MONOMER.
UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinate/shikimate dehydrogenase (EC:1.1.1.282)
Alternative name(s):
NAD-dependent shikimate 5-dehydrogenase 2
Gene namesi
Name:ydiB
Ordered Locus Names:c2087
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Quinate/shikimate dehydrogenaseUniRule annotationPRO_0000136071Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

MINTiMINT-1283296.
STRINGi199310.c2087.

Structurei

3D structure databases

ProteinModelPortaliP0A6D6.
SMRiP0A6D6. Positions 5-288.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000237875.
KOiK05887.
OMAiERIWLGV.
OrthoDBiEOG64R67G.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
MF_01578. Shikimate_DH_YdiB.
InterProiIPR016040. NAD(P)-bd_dom.
IPR022872. Quinate/Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A6D6-1 [UniParc]FASTAAdd to Basket

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MDVTAKYELI GLMAYPIRHS LSPEMQNKAL EKAGLPFTYM AFEVDNDSFP    50
GAIEGLKALK MRGTGVSMPN KQLACEYVDE LTPAAKLVGA INTIVNDDGY 100
LRGYNTDGTG HIRAIKESGF DIKGKTMVLL GAGGASTAIG AQGAIEGLKE 150
IKLFNRRDEF FDKALAFAQR VNENTDCVVT VTDLADQQAF AEALASADIL 200
TNGTKVGMKP LENESLVNDI SLLHPGLLVT ECVYNPHMTK LLQQAQQAGC 250
KTIDGYGMLL WQGAEQFTLW TGKDFPLEYV KQVMGFGA 288
Length:288
Mass (Da):31,228
Last modified:June 7, 2005 - v1
Checksum:iC3D1415E03820A5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80547.1.
RefSeqiNP_753982.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80547; AAN80547; c2087.
GeneIDi1036366.
KEGGiecc:c2087.
PATRICi18282073. VBIEscCol75197_1953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80547.1 .
RefSeqi NP_753982.1. NC_004431.1.

3D structure databases

ProteinModelPortali P0A6D6.
SMRi P0A6D6. Positions 5-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1283296.
STRINGi 199310.c2087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80547 ; AAN80547 ; c2087 .
GeneIDi 1036366.
KEGGi ecc:c2087.
PATRICi 18282073. VBIEscCol75197_1953.

Phylogenomic databases

HOGENOMi HOG000237875.
KOi K05887.
OMAi ERIWLGV.
OrthoDBi EOG64R67G.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .
BioCyci ECOL199310:C2087-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
MF_01578. Shikimate_DH_YdiB.
InterProi IPR016040. NAD(P)-bd_dom.
IPR022872. Quinate/Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiYDIB_ECOL6
AccessioniPrimary (citable) accession number: P0A6D6
Secondary accession number(s): P28244, P77647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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