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Protein

Acyl carrier protein

Gene

acpP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

  • acyl binding Source: EcoliWiki
  • acyl carrier activity Source: EcoliWiki
  • lipid binding Source: CAFA
  • phosphopantetheine binding Source: EcoliWiki

GO - Biological processi

  • fatty acid biosynthetic process Source: EcoliWiki
  • lipid A biosynthetic process Source: EcoliWiki
  • lipid biosynthetic process Source: EcoliWiki
  • response to drug Source: EcoliWiki

Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG50003-MONOMER.
MetaCyc:EG50003-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier proteinUniRule annotation
Short name:
ACPUniRule annotation
Alternative name(s):
Cytosolic-activating factor
Short name:
CAF
Fatty acid synthase acyl carrier protein
Gene namesi
Name:acpPUniRule annotation
Ordered Locus Names:b1094, JW1080
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG50003. acpP.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi37S → A or T: Loss of phosphopantetheinylation, and inhibition of cell growth. 1 Publication1

Chemistry databases

DrugBankiDB04450. Heptyl 1-Thiohexopyranoside.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001801342 – 78Acyl carrier proteinAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiP0A6A8.
PRIDEiP0A6A8.

Interactioni

Subunit structurei

Interacts with MukB.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4263360. 478 interactors.
DIPiDIP-29374N.
IntActiP0A6A8. 45 interactors.
MINTiMINT-1231626.
STRINGi316385.ECDH10B_1166.

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Helixi20 – 22Combined sources3
Turni29 – 33Combined sources5
Helixi37 – 51Combined sources15
Helixi57 – 60Combined sources4
Helixi66 – 75Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ACPNMR-A2-78[»]
1L0HX-ray2.00A1-77[»]
1L0IX-ray1.20A1-78[»]
1T8KX-ray1.10A2-78[»]
2FACX-ray1.76A/B2-78[»]
2FADX-ray1.60A/B2-78[»]
2FAEX-ray1.55A/B2-78[»]
2FHSX-ray2.70C1-78[»]
2K92NMR-A2-78[»]
2K93NMR-A2-78[»]
2K94NMR-A2-78[»]
3EJBX-ray2.00A/C/E/G1-78[»]
3EJDX-ray2.10A/C/E/G1-78[»]
3EJEX-ray2.10A/C/E/G1-78[»]
3NY7X-ray1.92B1-78[»]
5USRX-ray3.09I/J/K/L1-78[»]
5WGBX-ray2.75C2-78[»]
ProteinModelPortaliP0A6A8.
SMRiP0A6A8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A6A8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77CarrierPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0236. LUCA.
HOGENOMiHOG000178184.
InParanoidiP0A6A8.
KOiK02078.
PhylomeDBiP0A6A8.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiView protein in InterPro
IPR036736. ACP-like_sf.
IPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
PfamiView protein in Pfam
PF00550. PP-binding. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887. PD000887. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiView protein in PROSITE
PS50075. CARRIER. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A6A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIEERVKK IIGEQLGVKQ EEVTNNASFV EDLGADSLDT VELVMALEEE
60 70
FDTEIPDEEA EKITTVQAAI DYINGHQA
Length:78
Mass (Da):8,640
Last modified:January 23, 2007 - v2
Checksum:i41FCFC39D45BFEA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25N → D AA sequence (PubMed:4882207).Curated1
Sequence conflicti44V → I AA sequence (PubMed:3549687).Curated1
Sequence conflicti71D → V in AAB27925 (PubMed:8359454).Curated1
Sequence conflicti76H → N in AAB27925 (PubMed:8359454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84991 Genomic DNA. Translation: AAA23740.1.
S65033 Genomic DNA. Translation: AAB27925.2.
U00096 Genomic DNA. Translation: AAC74178.1.
AP009048 Genomic DNA. Translation: BAA35902.1.
Z34979 Genomic DNA. No translation available.
PIRiC42147. AYEC.
RefSeqiNP_415612.1. NC_000913.3.
WP_000103754.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74178; AAC74178; b1094.
BAA35902; BAA35902; BAA35902.
GeneIDi32369337.
944805.
KEGGiecj:JW1080.
eco:b1094.
PATRICifig|1411691.4.peg.1174.

Similar proteinsi

Entry informationi

Entry nameiACP_ECOLI
AccessioniPrimary (citable) accession number: P0A6A8
Secondary accession number(s): P02901, Q53352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families