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Protein

Iron-dependent repressor IdeR

Gene

ideR

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-dependent repressor IdeR
Gene namesi
Name:ideR
Synonyms:dtxR
Ordered Locus Names:Mb2730
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Iron-dependent repressor IdeRPRO_0000201109Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A673.
SMRiP0A673. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6562HTH dtxR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH dtxR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000096101.
KOiK03709.
OMAiQFRIRRI.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
InterProiIPR007167. Fe-transptr_FeoA.
IPR001367. Fe_dep_repressor.
IPR022687. HTH_DTXR.
IPR022689. Iron_dep_repressor.
IPR008988. Transcriptional_repressor_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
PF04023. FeoA. 1 hit.
[Graphical view]
SMARTiSM00899. FeoA. 1 hit.
SM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47979. SSF47979. 1 hit.
SSF50037. SSF50037. 1 hit.
PROSITEiPS50944. HTH_DTXR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELVDTTEM YLRTIYDLEE EGVTPLRARI AERLDQSGPT VSQTVSRMER
60 70 80 90 100
DGLLRVAGDR HLELTEKGRA LAIAVMRKHR LAERLLVDVI GLPWEEVHAE
110 120 130 140 150
ACRWEHVMSE DVERRLVKVL NNPTTSPFGN PIPGLVELGV GPEPGADDAN
160 170 180 190 200
LVRLTELPAG SPVAVVVRQL TEHVQGDIDL ITRLKDAGVV PNARVTVETT
210 220 230
PGGGVTIVIP GHENVTLPHE MAHAVKVEKV
Length:230
Mass (Da):25,233
Last modified:March 15, 2005 - v1
Checksum:i77B9CA98E04BDC27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43994.1.
RefSeqiNP_856376.1. NC_002945.3.
WP_003413962.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43994; CDO43994; Mb2730.
GeneIDi1091878.
KEGGimbo:Mb2730.
PATRICi18007719. VBIMycBov88188_2992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43994.1.
RefSeqiNP_856376.1. NC_002945.3.
WP_003413962.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A673.
SMRiP0A673. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43994; CDO43994; Mb2730.
GeneIDi1091878.
KEGGimbo:Mb2730.
PATRICi18007719. VBIMycBov88188_2992.

Phylogenomic databases

HOGENOMiHOG000096101.
KOiK03709.
OMAiQFRIRRI.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
InterProiIPR007167. Fe-transptr_FeoA.
IPR001367. Fe_dep_repressor.
IPR022687. HTH_DTXR.
IPR022689. Iron_dep_repressor.
IPR008988. Transcriptional_repressor_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
PF04023. FeoA. 1 hit.
[Graphical view]
SMARTiSM00899. FeoA. 1 hit.
SM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47979. SSF47979. 1 hit.
SSF50037. SSF50037. 1 hit.
PROSITEiPS50944. HTH_DTXR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDER_MYCBO
AccessioniPrimary (citable) accession number: P0A673
Secondary accession number(s): O08190, Q50495, X2BLC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.