P0A633 (TRPC_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Mb1637

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154235
Regions
	Compositional bias	32 – 37	6	Poly-Ala HAMAP MF_00134_B

Sequences

	Sequence		Length	Mass (Da)
	P0A633 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 9CA29D0F0FAC76C2	FASTA	272	28,023
	10 20 30 40 50 60 MSPATVLDSI LEGVRADVAA REASVSLSEI KAAAAAAPPP LDVMAALREP GIGVIAEVKR 70 80 90 100 110 120 ASPSAGALAT IADPAKLAQA YQDGGARIVS VVTEQRRFQG SLDDLDAVRA SVSIPVLRKD 130 140 150 160 170 180 FVVQPYQIHE ARAHGADMLL LIVAALEQSV LVSMLDRTES LGMTALVEVH TEQEADRALK 190 200 210 220 230 240 AGAKVIGVNA RDLMTLDVDR DCFARIAPGL PSSVIRIAES GVRGTADLLA YAGAGADAVL 250 260 270 VGEGLVTSGD PRAAVADLVT AGTHPSCPKP AR

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248339 Genomic DNA. Translation: CAD96305.1.
RefSeq	NP_855290.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P0A633.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000018081; EBMYCP00000017916; EBMYCG00000018076.
GeneID	1092568.
GenomeReviews	Gene locus Mb1637 in contig BX248333_GR.
KEGG	mbo:Mb1637.
PATRIC	18005277. VBIMycBov88188_1786.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017090.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MBOV233413:MB1637-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_MYCBO

Accession

Primary (citable) accession number: P0A633
Secondary accession number(s): O06129

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program