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P0A623 (ILVB_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetolactate synthase
EC=2.2.1.6
Alternative name(s):
ALS
Acetohydroxy-acid synthase
Gene names
Name:ilvB
Ordered Locus Names:Mb3028c
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Sequence similarities

Belongs to the TPP enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618Acetolactate synthase
PRO_0000090801

Regions

Nucleotide binding293 – 31422FAD By similarity
Nucleotide binding336 – 35520FAD By similarity
Region429 – 50981Thiamine pyrophosphate binding

Sites

Metal binding4801Magnesium By similarity
Metal binding5071Magnesium By similarity
Binding site851Thiamine pyrophosphate By similarity
Binding site1871FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A623 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 9E0523F4AD6EC6AF

FASTA61866,123
        10         20         30         40         50         60 
MSAPTKPHSP TFKPEPHSAA NEPKHPAARP KHVALQQLTG AQAVIRSLEE LGVDVIFGIP 

        70         80         90        100        110        120 
GGAVLPVYDP LFDSKKLRHV LVRHEQGAGH AASGYAHVTG RVGVCMATSG PGATNLVTPL 

       130        140        150        160        170        180 
ADAQMDSIPV VAITGQVGRG LIGTDAFQEA DISGITMPIT KHNFLVRSGD DIPRVLAEAF 

       190        200        210        220        230        240 
HIAASGRPGA VLVDIPKDVL QGQCTFSWPP RMELPGYKPN TKPHSRQVRE AAKLIAAARK 

       250        260        270        280        290        300 
PVLYVGGGVI RGEATEQLRE LAELTGIPVV TTLMARGAFP DSHRQNLGMP GMHGTVAAVA 

       310        320        330        340        350        360 
ALQRSDLLIA LGTRFDDRVT GKLDSFAPEA KVIHADIDPA EIGKNRHADV PIVGDVKAVI 

       370        380        390        400        410        420 
TELIAMLRHH HIPGTIEMAD WWAYLNGVRK TYPLSYGPQS DGSLSPEYVI EKLGEIAGPD 

       430        440        450        460        470        480 
AVFVAGVGQH QMWAAQFIRY EKPRSWLNSG GLGTMGFAIP AAMGAKIALP GTEVWAIDGD 

       490        500        510        520        530        540 
GCFQMTNQEL ATCAVEGIPV KVALINNGNL GMVRQWQSLF YAERYSQTDL ATHSHRIPDF 

       550        560        570        580        590        600 
VKLAEALGCV GLRCEREEDV VDVINQARAI NDCPVVIDFI VGADAQVWPM VAAGTSNDEI 

       610 
QAARGIRPLF DDITEGHA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248344 Genomic DNA. Translation: CAD96715.1.
RefSeqNP_856673.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A623.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000017215; EBMYCP00000017050; EBMYCG00000017210.
GeneID1093674.
GenomeReviewsGene locus Mb3028c in contig BX248333_GR.
KEGGmbo:Mb3028c.
PATRIC18008396. VBIMycBov88188_3328.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000014643.
HOGENOMHBG323037.
OMAHSWRYDH.
ProtClustDBPRK07789.

Enzyme and pathway databases

BioCycMBOV233413:MB3028C-MONOMER.

Family and domain databases

InterProIPR012846. Acetolactate_synth_lsu.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
KOK01652.
PANTHERPTHR18968:SF13. PTHR18968:SF13. 1 hit.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00118. Acolac_lg. 1 hit.
PROSITEPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVB_MYCBO
AccessionPrimary (citable) accession number: P0A623
Secondary accession number(s): O53250
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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