P0A612 (SSRP_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SsrA-binding protein

Gene names

Name:	smpB
Ordered Locus Names:	Rv3100c, MT3184
ORF Names:	MTCY164.11c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes By similarity. HAMAP MF_00023
Subcellular location	Cytoplasm Potential HAMAP MF_00023.
Sequence similarities	Belongs to the SmpB family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: MTBBASE
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: MTBBASE
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	SsrA-binding protein HAMAP MF_00023		PRO_0000102991
Experimental info
	Sequence conflict	14	1	S → R in CAA49621. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0A612 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 949F6327A03ACCD3	FASTA	160	18,230
	10 20 30 40 50 60 MSKSSRGGRQ IVASNRKARH NYSIIEVFEA GVALQGTEVK SLREGQASLA DSFATIDDGE 70 80 90 100 110 120 VWLRNAHIPE YRHGSWTNHE PRRNRKLLLH RRQIDTLVGK IREGNFALVP LSLYFAEGKV 130 140 150 160 KVELALARGK QARDKRQDMA RRDAQREVLR ELGRRAKGMT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An M. tuberculosis DNA fragment contains genes encoding cell division proteins ftsX and ftsE, a basic protein and homologues of PemK and small protein B." Tyagi J.S., Das T.K., Kinger A.K. Gene 177:59-67(1996) [PubMed: 8921846] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[3]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70031 Genomic DNA. Translation: CAA49621.1. BX842582 Genomic DNA. Translation: CAB08390.1. AE000516 Genomic DNA. Translation: AAK47522.1.
PIR	C70919.
RefSeq	NP_217616.1. NC_000962.2. NP_337708.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P0A612.
SMR	P0A612. Positions 11-130.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000002688; EBMYCP00000002688; EBMYCG00000002686. EBMYCT00000071926; EBMYCP00000069985; EBMYCG00000071921.
GeneID	888675. 926706.
GenomeReviews	Gene locus MT3184 in contig AE000516_GR. Gene locus Rv3100c in contig AL123456_GR.
KEGG	mtc:MT3184. mtu:Rv3100c.
PATRIC	18128768. VBIMycTub22151_3481.
TIGR	MT3184.
Organism-specific databases
TubercuList	Rv3100c.
Phylogenomic databases
GeneTree	EBGT00050000017126.
HOGENOM	HBG293422.
OMA	EKYEAGI.
PhylomeDB	P0A612.
ProtClustDB	PRK05422.
Family and domain databases
HAMAP	MF_00023. SmpB. [Tree]
InterPro	IPR023620. SmpB. IPR000037. SsrA-bd_prot. IPR020081. SsrA-bd_prot_CS. [Graphical view]
Gene3D	G3DSA:2.40.280.10. SmpB. 1 hit.
KO	K03664.
Pfam	PF01668. SmpB. 1 hit. [Graphical view]
ProDom	PD004488. SmpB. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF74982. SmpB. 1 hit.
TIGRFAMs	TIGR00086. SmpB. 1 hit.
PROSITE	PS01317. SSRP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSRP_MYCTU

Accession

Primary (citable) accession number: P0A612
Secondary accession number(s): O05778, P96294

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program