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P0A605 (GMHA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoheptose isomerase
EC=5.3.1.28
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene names
Name:gmhA
Synonyms:lpcA
Ordered Locus Names:Mb0117
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067

Catalytic activity

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. HAMAP MF_00067

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00067

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. HAMAP MF_00067

Subcellular location

Cytoplasm By similarity HAMAP MF_00067.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Contains 1 SIS domain.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionD-sedoheptulose 7-phosphate isomerase activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sugar binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196Phosphoheptose isomerase HAMAP MF_00067
PRO_0000136537

Regions

Domain38 – 196159SIS
Region53 – 553Substrate binding By similarity
Region95 – 962Substrate binding By similarity
Region121 – 1233Substrate binding By similarity

Sites

Metal binding621Zinc By similarity
Metal binding661Zinc By similarity
Metal binding1731Zinc By similarity
Metal binding1811Zinc By similarity
Binding site661Substrate By similarity
Binding site1261Substrate By similarity
Binding site1731Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A605 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 0F05EB968F1189CB

FASTA19620,923
        10         20         30         40         50         60 
MCTARTAEEI FVETIAVKTR ILNDRVLLEA ARAIGDRLIA GYRAGARVFM CGNGGSAADA 

        70         80         90        100        110        120 
QHFAAELTGH LIFDRPPLGA EALHANSSHL TAVANDYDYD TVFARALEGS ARPGDTLFAI 

       130        140        150        160        170        180 
STSGNSMSVL RAAKTARELG VTVVAMTGES GGQLAEFADF LINVPSRDTG RIQESHIVFI 

       190 
HAISEHVEHA LFAPRQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248334 Genomic DNA. Translation: CAD92978.1.
RefSeqNP_853784.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A605.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000015072; EBMYCP00000014907; EBMYCG00000015069.
GeneID1090800.
GenomeReviewsGene locus Mb0117 in contig BX248333_GR.
KEGGmbo:Mb0117.
PATRIC18001922. VBIMycBov88188_0129.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016047.
HOGENOMHBG671955.
OMAHITIIHI.
ProtClustDBPRK13938.

Enzyme and pathway databases

BioCycMBOV233413:MB0117-MONOMER.

Family and domain databases

HAMAPMF_00067. GmhA.
[Tree]
InterProIPR020620. Phosphoheptose_isomerase.
IPR001347. SIS.
[Graphical view]
KOK03271.
PfamPF01380. SIS. 1 hit.
[Graphical view]
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGMHA_MYCBO
AccessionPrimary (citable) accession number: P0A605
Secondary accession number(s): O53635
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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