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Protein

Protein translocase subunit SecA 1

Gene

secA1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA 1UniRule annotation
Gene namesi
Name:secA1UniRule annotation
Ordered Locus Names:Mb3268c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi129 – 1291T → I: Azide resistant. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Protein translocase subunit SecA 1PRO_0000109591Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0A5Y9.
SMRiP0A5Y9. Positions 1-835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A5Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLLRLGE GRMVKRLKKV ADYVGTLSDD VEKLTDAELR AKTDEFKRRL
60 70 80 90 100
ADQKNPETLD DLLPEAFAVA REAAWRVLDQ RPFDVQVMGA AALHLGNVAE
110 120 130 140 150
MKTGEGKTLT CVLPAYLNAL AGNGVHIVTV NDYLAKRDSE WMGRVHRFLG
160 170 180 190 200
LQVGVILATM TPDERRVAYN ADITYGTNNE FGFDYLRDNM AHSLDDLVQR
210 220 230 240 250
GHHYAIVDEV DSILIDEART PLIISGPADG ASNWYTEFAR LAPLMEKDVH
260 270 280 290 300
YEVDLRKRTV GVHEKGVEFV EDQLGIDNLY EAANSPLVSY LNNALKAKEL
310 320 330 340 350
FSRDKDYIVR DGEVLIVDEF TGRVLIGRRY NEGMHQAIEA KEHVEIKAEN
360 370 380 390 400
QTLATITLQN YFRLYDKLAG MTGTAQTEAA ELHEIYKLGV VSIPTNMPMI
410 420 430 440 450
REDQSDLIYK TEEAKYIAVV DDVAERYAKG QPVLIGTTSV ERSEYLSRQF
460 470 480 490 500
TKRRIPHNVL NAKYHEQEAT IIAVAGRRGG VTVATNMAGR GTDIVLGGNV
510 520 530 540 550
DFLTDQRLRE RGLDPVETPE EYEAAWHSEL PIVKEEASKE AKEVIEAGGL
560 570 580 590 600
YVLGTERHES RRIDNQLRGR SGRQGDPGES RFYLSLGDEL MRRFNGAALE
610 620 630 640 650
TLLTRLNLPD DVPIEAKMVT RAIKSAQTQV EQQNFEVRKN VLKYDEVMNQ
660 670 680 690 700
QRKVIYAERR RILEGENLKD QALDMVRDVI TAYVDGATGE GYAEDWDLDA
710 720 730 740 750
LWTALKTLYP VGITADSLTR KDHEFERDDL TREELLEALL KDAERAYAAR
760 770 780 790 800
EAELEEIAGE GAMRQLERNV LLNVIDRKWR EHLYEMDYLK EGIGLRAMAQ
810 820 830 840 850
RDPLVEYQRE GYDMFMAMLD GMKEESVGFL FNVTVEAVPA PPVAPAAEPA
860 870 880 890 900
ELAEFAAAAA AAAQQRSAVD GGARERAPSA LRAKGVASES PALTYSGPAE
910 920 930 940
DGSAQVQRNG GGAHKTPAGV PAGASRRERR EAARRQGRGA KPPKSVKKR
Length:949
Mass (Da):106,022
Last modified:March 15, 2005 - v1
Checksum:iD46C3315835E03D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2399ASNWYTEFA → LQLVHRVR in AAC34131 (PubMed:11717254).Curated
Sequence conflicti334 – 3352MH → ID in AAC34131 (PubMed:11717254).Curated
Sequence conflicti711 – 7111V → E in AAC34131 (PubMed:11717254).Curated
Sequence conflicti800 – 8012QR → HG in AAC34131 (PubMed:11717254).Curated
Sequence conflicti932 – 9321A → R in AAC34131 (PubMed:11717254).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66080 Genomic DNA. Translation: AAC34131.1.
BX248333 Genomic DNA. Translation: CDO44540.1.
RefSeqiNP_856913.1. NC_002945.3.
WP_003901576.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO44540; CDO44540; Mb3268c.
GeneIDi1093994.
KEGGimbo:Mb3268c.
PATRICi18008934. VBIMycBov88188_3595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66080 Genomic DNA. Translation: AAC34131.1.
BX248333 Genomic DNA. Translation: CDO44540.1.
RefSeqiNP_856913.1. NC_002945.3.
WP_003901576.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A5Y9.
SMRiP0A5Y9. Positions 1-835.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO44540; CDO44540; Mb3268c.
GeneIDi1093994.
KEGGimbo:Mb3268c.
PATRICi18008934. VBIMycBov88188_3595.

Phylogenomic databases

HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA1_MYCBO
AccessioniPrimary (citable) accession number: P0A5Y9
Secondary accession number(s): O05885, P71494, X2BNE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.