Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0A5Y7

- INHA_MYCBO

UniProt

P0A5Y7 - INHA_MYCBO

Protein

Enoyl-[acyl-carrier-protein] reductase [NADH]

Gene

inhA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide.

    Catalytic activityi

    An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei158 – 1581SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi136 – 16530NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Antibiotic resistance, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH] (EC:1.3.1.9)
    Alternative name(s):
    NADH-dependent enoyl-ACP reductase
    Gene namesi
    Name:inhA
    Ordered Locus Names:Mb1520
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Enoyl-[acyl-carrier-protein] reductase [NADH]PRO_0000054915Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi233413.Mb1520.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A5Y7.
    SMRiP0A5Y7. Positions 2-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0623.
    KOiK11611.
    OMAiTIIYADG.
    OrthoDBiEOG6HF644.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A5Y7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGLLDGKRI LVSGIITDSS IAFHIARVAQ EQGAQLVLTG FDRLRLIQRI    50
    TDRLPAKAPL LELDVQNEEH LASLAGRVTE AIGAGNKLDG VVHSIGFMPQ 100
    TGMGINPFFD APYADVSKGI HISAYSYASM AKALLPIMNP GGSIVGMDFD 150
    PSRAMPAYNW MTVAKSALES VNRFVAREAG KYGVRSNLVA AGPIRTLAMS 200
    AIVGGALGEE AGAQIQLLEE GWDQRAPIGW NMKDATPVAK TVCALLSDWL 250
    PATTGDIIYA DGGAHTQLL 269
    Length:269
    Mass (Da):28,528
    Last modified:March 15, 2005 - v1
    Checksum:iF161D6D6A631CA08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41388 Genomic DNA. Translation: AAB60183.1.
    BX248333 Genomic DNA. Translation: CDO42768.1.
    RefSeqiNP_855172.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96187; CAD96187; Mb1520.
    GeneIDi1092377.
    KEGGimbo:Mb1520.
    PATRICi18005028. VBIMycBov88188_1661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41388 Genomic DNA. Translation: AAB60183.1 .
    BX248333 Genomic DNA. Translation: CDO42768.1 .
    RefSeqi NP_855172.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P0A5Y7.
    SMRi P0A5Y7. Positions 2-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb1520.

    Chemistry

    BindingDBi P0A5Y7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96187 ; CAD96187 ; Mb1520 .
    GeneIDi 1092377.
    KEGGi mbo:Mb1520.
    PATRICi 18005028. VBIMycBov88188_1661.

    Phylogenomic databases

    eggNOGi COG0623.
    KOi K11611.
    OMAi TIIYADG.
    OrthoDBi EOG6HF644.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis."
      Banerjee A., Dubnau E., Quemard A., Balasubramanian V., Um K.S., Wilson T., Collins D., de Lisle G., Jacobs W.R. Jr.
      Science 263:227-230(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BCG.
    2. "Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis."
      Wilson T.M., de Lisle G.W., Collins D.M.
      Mol. Microbiol. 15:1009-1015(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WAG201.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiINHA_MYCBO
    AccessioniPrimary (citable) accession number: P0A5Y7
    Secondary accession number(s): P46533, X2BIC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3