Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0A5Y7 (INHA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH]

EC=1.3.1.9
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene names
Name:inhA
Ordered Locus Names:Mb1520
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide.

Catalytic activity

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Enoyl-[acyl-carrier-protein] reductase [NADH]
PRO_0000054915

Regions

Nucleotide binding136 – 16530NAD Potential

Sites

Binding site1581Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A5Y7 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: F161D6D6A631CA08

FASTA26928,528
        10         20         30         40         50         60 
MTGLLDGKRI LVSGIITDSS IAFHIARVAQ EQGAQLVLTG FDRLRLIQRI TDRLPAKAPL 

        70         80         90        100        110        120 
LELDVQNEEH LASLAGRVTE AIGAGNKLDG VVHSIGFMPQ TGMGINPFFD APYADVSKGI 

       130        140        150        160        170        180 
HISAYSYASM AKALLPIMNP GGSIVGMDFD PSRAMPAYNW MTVAKSALES VNRFVAREAG 

       190        200        210        220        230        240 
KYGVRSNLVA AGPIRTLAMS AIVGGALGEE AGAQIQLLEE GWDQRAPIGW NMKDATPVAK 

       250        260 
TVCALLSDWL PATTGDIIYA DGGAHTQLL 

« Hide

References

« Hide 'large scale' references
[1]"inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis."
Banerjee A., Dubnau E., Quemard A., Balasubramanian V., Um K.S., Wilson T., Collins D., de Lisle G., Jacobs W.R. Jr.
Science 263:227-230(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BCG.
[2]"Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis."
Wilson T.M., de Lisle G.W., Collins D.M.
Mol. Microbiol. 15:1009-1015(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: WAG201.
[3]"The complete genome sequence of Mycobacterium bovis."
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. expand/collapse author list , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41388 Genomic DNA. Translation: AAB60183.1.
BX248339 Genomic DNA. Translation: CAD96187.1.
RefSeqNP_855172.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A5Y7.
SMRP0A5Y7. Positions 2-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb1520.

Chemistry

BindingDBP0A5Y7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD96187; CAD96187; Mb1520.
GeneID1092377.
KEGGmbo:Mb1520.
PATRIC18005028. VBIMycBov88188_1661.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0623.
KOK11611.
OMADCDVGSD.
OrthoDBEOG6HF644.
ProtClustDBPRK07889.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
ProtoNetSearch...

Entry information

Entry nameINHA_MYCBO
AccessionPrimary (citable) accession number: P0A5Y7
Secondary accession number(s): P46533
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 22, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways