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P0A5Y5 (FABG_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG
EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Synonyms:fabG1
Ordered Locus Names:Mb1519
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2472473-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054676

Regions

Nucleotide binding22 – 254NADP By similarity
Nucleotide binding61 – 622NADP By similarity
Nucleotide binding153 – 1575NADP By similarity

Sites

Active site1531Proton acceptor By similarity
Binding site471NADP By similarity
Binding site881NADP; via carbonyl oxygen By similarity
Binding site1401Substrate By similarity
Binding site1861NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A5Y5 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 70F6254B0FFFCD47

FASTA24725,697
        10         20         30         40         50         60 
MTATATEGAK PPFVSRSVLV TGGNRGIGLA IAQRLAADGH KVAVTHRGSG APKGLFGVEC 

        70         80         90        100        110        120 
DVTDSDAVDR AFTAVEEHQG PVEVLVSNAG LSADAFLMRM TEEKFEKVIN ANLTGAFRVA 

       130        140        150        160        170        180 
QRASRSMQRN KFGRMIFIGS VSGSWGIGNQ ANYAASKAGV IGMARSIARE LSKANVTANV 

       190        200        210        220        230        240 
VAPGYIDTDM TRALDERIQQ GALQFIPAKR VGTPAEVAGV VSFLASEDAS YISGAVIPVD 


GGMGMGH

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U41388 Genomic DNA. Translation: AAB60182.1.
BX248339 Genomic DNA. Translation: CAD96186.1.
RefSeqNP_855171.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A5Y5.
SMRP0A5Y5. Positions 9-247.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000017301; EBMYCP00000017136; EBMYCG00000017296.
GeneID1092376.
GenomeReviewsGene locus Mb1519 in contig BX248333_GR.
KEGGmbo:Mb1519.
PATRIC18005026. VBIMycBov88188_1660.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015165.
HOGENOMHBG750976.
OMAAFLIRMT.
ProtClustDBCLSK871938.

Enzyme and pathway databases

BioCycMBOV233413:MB1519-MONOMER.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK11610.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_MYCBO
AccessionPrimary (citable) accession number: P0A5Y5
Secondary accession number(s): P71764, Q48930
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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